{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:49:34Z","timestamp":1792032574677,"version":"4.4.0"},"reference-count":22,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Our laboratory has recently discovered a novel candidate oncogene, MCT-1, amplified in human T-cell lymphoma and mapped to chromosome Xq22-24. This region is amplified in a subset of primary B-cell non-Hodgkin lymphoma (NHL), suggesting that increased copy number of a gene(s) located in this region confers a growth advantage to some primary human lymphomas. We examined a diverse panel of lymphoid malignancies for the expression of MCT-1. We demonstrated that there are significantly increased levels of MCT-1 protein in a panel of T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines. Furthermore, we identified a subset of primary diffuse large B-cell lymphomas that exhibited elevated levels of MCT-1 protein. Interestingly, all transformed follicular lymphomas in our study demonstrated elevated protein levels of MCT-1. There was no detectable MCT-1 protein in leukemic cells from patients with chronic lymphocytic leukemia or in any healthy lymphoid tissue examined. Lymphoid cell lines overexpressing MCT-1 exhibited increased growth rates and displayed increased protection against apoptosis induced by serum starvation when compared with matched controls. We found that MCT-1\u2014overexpressing cells show constitutively higher levels of phosphorylated PKB\/Akt protein, especially under serum starvation. Activation of survival pathways may be an additional function of the MCT-1 gene. Our data suggest that high levels of MCT-1 protein may be associated with a high-risk subset of lymphoid neoplasms and may further support the potential role of MCT-1 in promoting human lymphoid tumor development. (Blood. 2003;102: 297-302)<\/jats:p>","DOI":"10.1182\/blood-2002-11-3486","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T16:13:45Z","timestamp":1048004025000},"page":"297-302","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":35,"title":["Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies"],"prefix":"10.1182","volume":"102","author":[{"given":"Bo","family":"Shi","sequence":"first","affiliation":[{"name":"From the Division of Hematology\/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Ling","family":"Hsu","sequence":"additional","affiliation":[{"name":"From the Division of Hematology\/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy M.","family":"Evens","sequence":"additional","affiliation":[{"name":"From the Division of Hematology\/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo I.","family":"Gordon","sequence":"additional","affiliation":[{"name":"From the Division of Hematology\/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald B.","family":"Gartenhaus","sequence":"additional","affiliation":[{"name":"From the Division of Hematology\/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021219255578600_REF1","doi-asserted-by":"crossref","unstructured":"Gartenhaus RB. 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