{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:04:14Z","timestamp":1790849054970,"version":"4.1.0"},"reference-count":55,"publisher":"American Society of Hematology","issue":"7","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MyD-1 (CD172) is a member of the family of signal regulatory phosphatase (SIRP) binding proteins, which is expressed on human CD14+ monocytes and dendritic cells. We now show a novel role for MyD-1 in the regulation of the innate immune system by pathogen products such as lipopolysaccharide (LPS), purified protein derivative (PPD), and Zymosan. Specifically, we demonstrate that ligation of MyD-1 on peripheral blood mononuclear cells (PBMCs) inhibits tumor necrosis factor alpha (TNF\u03b1) secretion but has no effect on other cytokines induced in response to each of these products. In an attempt to understand the molecular mechanisms underlying this surprisingly selective effect we investigated signal transduction pathways coupled to MyD-1. Ligation of the SIRP was found to recruit the tyrosine phosphatase SHP-2 and promote sequential activation of phosphatidylinositol (PI) 3-kinase, phospholipase D, and sphingosine kinase. Inhibition of LPS-induced TNF\u03b1 secretion by MyD-1 appears to be mediated by this pathway, as the PI 3-kinase inhibitor wortmannin restores normal LPS-driven TNF\u03b1 secretion. MyD-1-coupling to this PI 3-kinase-dependent signaling pathway may therefore present a novel target for the development of therapeutic strategies for combating TNF\u03b1 production and consequent inflammatory disease. (Blood. 2003;102:2532-2540)<\/jats:p>","DOI":"10.1182\/blood-2002-11-3596","type":"journal-article","created":{"date-parts":[[2003,6,17]],"date-time":"2003-06-17T00:34:45Z","timestamp":1055810085000},"page":"2532-2540","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":53,"title":["A novel MyD-1 (SIRP-1\u03b1) signaling pathway that inhibits LPS-induced TNF\u03b1 production by monocytes"],"prefix":"10.1182","volume":"102","author":[{"given":"Rosemary E.","family":"Smith","sequence":"first","affiliation":[{"name":"From the Edward Jenner Institute for Vaccine Research and the Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom; the Division of Immunology, Infection and Inflammation, University of Glasgow; the Department of Immunology, University of Strathclyde, United Kingdom; and the Sir William Dunn School of Pathology, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanshree","family":"Patel","sequence":"additional","affiliation":[{"name":"From the Edward Jenner Institute for Vaccine Research and the Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom; the Division of Immunology, Infection and Inflammation, University of Glasgow; the Department of Immunology, University of Strathclyde, United Kingdom; and the Sir William Dunn School of Pathology, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra D.","family":"Seatter","sequence":"additional","affiliation":[{"name":"From the Edward Jenner Institute for Vaccine Research and the Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom; the Division of Immunology, Infection and Inflammation, University of Glasgow; the Department of Immunology, University of Strathclyde, United Kingdom; and the Sir William Dunn School of Pathology, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen R.","family":"Deehan","sequence":"additional","affiliation":[{"name":"From the Edward Jenner Institute for Vaccine Research and the Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom; the Division of Immunology, Infection and Inflammation, University of Glasgow; the Department of Immunology, University of Strathclyde, United Kingdom; and the Sir William Dunn School of Pathology, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion H.","family":"Brown","sequence":"additional","affiliation":[{"name":"From the Edward Jenner Institute for Vaccine Research and the Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom; the Division of Immunology, Infection and Inflammation, University of Glasgow; the Department of Immunology, University of Strathclyde, United Kingdom; and the Sir William Dunn School of Pathology, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth P.","family":"Brooke","sequence":"additional","affiliation":[{"name":"From the Edward Jenner Institute for Vaccine Research and the Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom; the Division of Immunology, Infection and Inflammation, University of Glasgow; the Department of Immunology, University of Strathclyde, United Kingdom; and the Sir William Dunn School of Pathology, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen S.","family":"Goodridge","sequence":"additional","affiliation":[{"name":"From the Edward Jenner Institute for Vaccine Research and the Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom; the Division of Immunology, Infection and Inflammation, University of Glasgow; the Department of Immunology, University of Strathclyde, United Kingdom; and the Sir William Dunn School of Pathology, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Howard","sequence":"additional","affiliation":[{"name":"From the Edward Jenner Institute for Vaccine Research and the Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom; the Division of Immunology, Infection and Inflammation, University of Glasgow; the Department of Immunology, University of Strathclyde, United Kingdom; and the Sir William Dunn School of Pathology, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"Rigley","sequence":"additional","affiliation":[{"name":"From the Edward Jenner Institute for Vaccine Research and the Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom; the Division of Immunology, Infection and Inflammation, University of Glasgow; the Department of Immunology, University of Strathclyde, United Kingdom; and the Sir William Dunn School of Pathology, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Harnett","sequence":"additional","affiliation":[{"name":"From the Edward Jenner Institute for Vaccine Research and the Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom; the Division of Immunology, Infection and Inflammation, University of Glasgow; the Department of Immunology, University of Strathclyde, United Kingdom; and the Sir William Dunn School of Pathology, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret M.","family":"Harnett","sequence":"additional","affiliation":[{"name":"From the Edward Jenner Institute for Vaccine Research and the Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom; the Division of Immunology, Infection and Inflammation, University of Glasgow; the Department of Immunology, University of Strathclyde, United Kingdom; and the Sir William Dunn School of Pathology, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021222211054000_REF1","doi-asserted-by":"crossref","unstructured":"Brooke GP, Parsons KR, Howard CJ. 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