{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:02:36Z","timestamp":1791846156224,"version":"4.3.4"},"reference-count":30,"publisher":"American Society of Hematology","issue":"2","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recombinant human interleukin-11 (rhIL-11), a glycoprotein 130 (gp130)\u2013signaling cytokine approved for treatment of thrombocytopenia, also raises von Willebrand factor (VWF) and factor VIII (FVIII) by an unknown mechanism. Desmopressin (1-deamino-8-d-arginine vasopressin [DDAVP]) releases stored VWF and FVIII and is used for treatment of VWF and FVIII deficiencies. To compare the effect of these 2 agents, heterozygous von Willebrand disease (VWD) and normal dogs were treated with either rhIL-11 (50 \u03bcg\/kg\/d subcutaneously \u00d7 7 days) or DDAVP (5 \u03bcg\/kg\/d intravenously \u00d7 7 days). The rhIL-11 produced a gradual and sustained elevation of VWF and FVIII levels in both heterozygous VWD and normal dogs while DDAVP produced a rapid and unsustained increase. Importantly, rhIL-11 treatment produced a 2.5- to 11-fold increase in VWF mRNA in normal canine heart, aorta, and spleen but not in homozygous VWD dogs, thus identifying a mechanism for elevation of plasma VWF in vivo. Moreover, dogs pretreated with rhIL-11 retain a DDAVP-releasable pool of VWF and FVIII, suggesting that rhIL-11 does not significantly alter trafficking of these proteins to or from storage pools. The half-life of infused VWF is unchanged by rhIL-11 in homozygous VWD dogs. These results show that rhIL-11 and DDAVP raise plasma VWF by different mechanisms. Treatment with rhIL-11 with or without DDAVP may provide an alternative to plasma-derived products for some VWD and hemophilia A patients if it is shown safe in clinical trials.<\/jats:p>","DOI":"10.1182\/blood-2003-01-0290","type":"journal-article","created":{"date-parts":[[2003,3,25]],"date-time":"2003-03-25T01:50:10Z","timestamp":1048557010000},"page":"436-441","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":33,"title":["Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11 versus Weibel-Palade body release by desmopressin (DDAVP)"],"prefix":"10.1182","volume":"102","author":[{"given":"Eva H. N.","family":"Olsen","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill; Medical College of Wisconsin, Milwaukee; and Wyeth Research, Cambridge, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene S.","family":"McCain","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill; Medical College of Wisconsin, Milwaukee; and Wyeth Research, Cambridge, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth P.","family":"Merricks","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill; Medical College of Wisconsin, Milwaukee; and Wyeth Research, Cambridge, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Fischer","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill; Medical College of Wisconsin, Milwaukee; and Wyeth Research, Cambridge, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy M.","family":"Dillon","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill; Medical College of Wisconsin, Milwaukee; and Wyeth Research, Cambridge, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin A.","family":"Raymer","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill; Medical College of Wisconsin, Milwaukee; and Wyeth Research, Cambridge, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight A.","family":"Bellinger","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill; Medical College of Wisconsin, Milwaukee; and Wyeth Research, Cambridge, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scot A.","family":"Fahs","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill; Medical College of Wisconsin, Milwaukee; and Wyeth Research, Cambridge, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill; Medical College of Wisconsin, Milwaukee; and Wyeth Research, Cambridge, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"James C.","family":"Keith","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill; Medical College of Wisconsin, Milwaukee; and Wyeth Research, Cambridge, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Schaub","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill; Medical College of Wisconsin, Milwaukee; and Wyeth Research, Cambridge, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Nichols","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill; Medical College of Wisconsin, Milwaukee; and Wyeth Research, Cambridge, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021222164035200_REF1","doi-asserted-by":"crossref","unstructured":"Wagner DD. 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