{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T08:17:06Z","timestamp":1793434626275,"version":"4.5.0"},"reference-count":69,"publisher":"American Society of Hematology","issue":"5","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The most abundant intracellular proteins, heat shock proteins (HSPs), serve as molecular chaperones for regulatory and maturation pathways. Diverse families of HSPs have been shown to bind antigenic peptides and to play major roles in innate and adaptive immune responses through the common HSP receptor, CD91. HIV-1+ patients with Kaposi sarcoma (KS) were matched for CD4 count and HIV-1 RNA viral load to HIV-1+ patients without Kaposi sarcoma (and negative for Kaposisarcoma\u2013associated herpesvirus). We then investigated the pathways used by tumor lysates, viral lysates, and viral particles in their activation. In particular, we observed immune responses after HSP depletion using antitumor antibiotics and blockade of the common HSP receptor, CD91. Despite the impaired functional capacity of dendritic cells (DCs) derived from patients with KS, DCs retain the ability to prime the adaptive arm of the immune system through the common HSP receptor, leading to phenotypic activation and stimulation of tetramer-positive CD8+ cytotoxic T cells. We also show that interferon-producing plasmacytoid DCs are selectively depleted in KS-positive compared with matched KS-negative HIV-1\u2013infected patients. Functionally impaired DCs can effectively cross-present immune responses through the common HSP receptor. These results have important implications for the etiopathogenesis of KS and for the development and design of any compounds, including vaccines, derived from cellular lysates.<\/jats:p>","DOI":"10.1182\/blood-2003-03-0891","type":"journal-article","created":{"date-parts":[[2003,5,20]],"date-time":"2003-05-20T01:47:43Z","timestamp":1053395263000},"page":"1806-1814","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":34,"title":["Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor"],"prefix":"10.1182","volume":"102","author":[{"given":"Justin","family":"Stebbing","sequence":"first","affiliation":[{"name":"From the Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom; and the Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Gazzard","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom; and the Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Portsmouth","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom; and the Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Gotch","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom; and the Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom; and the Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bower","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom; and the Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundhiya","family":"Mandalia","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom; and the Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Binder","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom; and the Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod","family":"Srivastava","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom; and the Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Patterson","sequence":"additional","affiliation":[{"name":"From the Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, London, United Kingdom; and the Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021300263450000_REF1","doi-asserted-by":"crossref","unstructured":"Mayordomo JI, Zorina T, Storkus WJ, et al. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nat Med. 1995;1: 1297-1302.","DOI":"10.1038\/nm1295-1297"},{"key":"2020021300263450000_","doi-asserted-by":"crossref","unstructured":"Zitvogel L, Mayordomo JI, Tjandrawan T, et al. Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J Exp Med. 1996;183: 87-97.","DOI":"10.1084\/jem.183.1.87"},{"key":"2020021300263450000_REF3","doi-asserted-by":"crossref","unstructured":"Srivastava P. Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu Rev Immunol. 2002;20: 395-425.","DOI":"10.1146\/annurev.immunol.20.100301.064801"},{"key":"2020021300263450000_REF4","doi-asserted-by":"crossref","unstructured":"Chun TW, Stuyver L, Mizell SB, et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci U S A. 1997;94: 13193-13197.","DOI":"10.1073\/pnas.94.24.13193"},{"key":"2020021300263450000_","doi-asserted-by":"crossref","unstructured":"Chun TW, Carruth L, Finzi D, et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature. 1997;387: 183-188.","DOI":"10.1038\/387183a0"},{"key":"2020021300263450000_REF6","doi-asserted-by":"crossref","unstructured":"Finzi D, Blankson J, Siliciano JD, et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med. 1999;5: 512-517.","DOI":"10.1038\/8394"},{"key":"2020021300263450000_REF7","doi-asserted-by":"crossref","unstructured":"Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392: 245-252.","DOI":"10.1038\/32588"},{"key":"2020021300263450000_REF8","doi-asserted-by":"crossref","unstructured":"Binder RJ, Han DK, Srivastava PK. CD91: a receptor for heat shock protein gp96. Nat Immunol. 2000;1: 151-155.","DOI":"10.1038\/77835"},{"key":"2020021300263450000_REF9","doi-asserted-by":"crossref","unstructured":"Singh-Jasuja H, Scherer HU, Hilf N, et al. The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor. Eur J Immunol. 2000;30: 2211-2215.","DOI":"10.1002\/1521-4141(2000)30:18<2211::AID-IMMU2211>3.0.CO;2-H"},{"key":"2020021300263450000_REF10","doi-asserted-by":"crossref","unstructured":"Zheng H, Dai J, Stoilova D, Li Z. Cell surface targeting of heat shock protein gp96 induces dendritic cell maturation and antitumor immunity. J Immunol. 2001;167: 6731-6735.","DOI":"10.4049\/jimmunol.167.12.6731"},{"key":"2020021300263450000_REF11","doi-asserted-by":"crossref","unstructured":"Srivastava PK, Amato RJ. Heat shock proteins: the \u201cSwiss Army Knife\u201d vaccines against cancers and infectious agents. Vaccine. 2001;19: 2590-2597.","DOI":"10.1016\/S0264-410X(00)00492-8"},{"key":"2020021300263450000_REF12","doi-asserted-by":"crossref","unstructured":"Basu S, Binder RJ, Ramalingam T, Srivastava PK. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity. 2001;14: 303-313.","DOI":"10.1016\/S1074-7613(01)00111-X"},{"key":"2020021300263450000_REF13","doi-asserted-by":"crossref","unstructured":"Cella M, Jarrossay D, Facchetti F, et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med. 1999;5: 919-923.","DOI":"10.1038\/11360"},{"key":"2020021300263450000_REF14","doi-asserted-by":"crossref","unstructured":"Udono H, Levey DL, Srivastava PK. Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivo. Proc Natl Acad Sci U S A. 1994;91: 3077-3081.","DOI":"10.1073\/pnas.91.8.3077"},{"key":"2020021300263450000_REF15","doi-asserted-by":"crossref","unstructured":"Nieland TJ, Tan MC, Monne-van Muijen M, Koning F, Kruisbeek AM, van Bleek GM. Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96\/GRP94. Proc Natl Acad Sci U S A. 1996;93: 6135-6139.","DOI":"10.1073\/pnas.93.12.6135"},{"key":"2020021300263450000_REF16","doi-asserted-by":"crossref","unstructured":"Belli F, Testori A, Rivoltini L, et al. Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings. J Clin Oncol. 2002;20: 4169-4180.","DOI":"10.1200\/JCO.2002.09.134"},{"key":"2020021300263450000_REF17","doi-asserted-by":"crossref","unstructured":"Tamura Y, Peng P, Liu K, Daou M, Srivastava PK. Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations. Science. 1997;278: 117-120.","DOI":"10.1126\/science.278.5335.117"},{"key":"2020021300263450000_REF18","doi-asserted-by":"crossref","unstructured":"Blachere NE, Li Z, Chandawarkar RY, et al. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity. J Exp Med. 1997;186: 1315-1322.","DOI":"10.1084\/jem.186.8.1315"},{"key":"2020021300263450000_REF19","doi-asserted-by":"crossref","unstructured":"Moroi Y, Mayhew M, Trcka J, et al. Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70. Proc Natl Acad Sci U S A. 2000;97: 3485-3490.","DOI":"10.1073\/pnas.97.7.3485"},{"key":"2020021300263450000_REF20","doi-asserted-by":"crossref","unstructured":"Binder RJ, Karimeddini D, Srivastava PK. Adjuvanticity of alpha 2-macroglobulin, an independent ligand for the heat shock protein receptor CD91. J Immunol. 2001;166: 4968-4972.","DOI":"10.4049\/jimmunol.166.8.4968"},{"key":"2020021300263450000_REF21","doi-asserted-by":"crossref","unstructured":"Banchereau J, Pulendran B, Steinman R, Palucka K. Will the making of plasmacytoid dendritic cells in vitro help unravel their mysteries? J Exp Med. 2000;192: F39-F44.","DOI":"10.1084\/jem.192.12.F39"},{"key":"2020021300263450000_REF22","doi-asserted-by":"crossref","unstructured":"Chehimi J, Campbell DE, Azzoni L, et al. Persistent decreases in blood plasmacytoid dendritic cell number and function despite effective highly active antiretroviral therapy and increased blood myeloid dendritic cells in HIV-infected individuals. J Immunol. 2002;168: 4796-4801.","DOI":"10.4049\/jimmunol.168.9.4796"},{"key":"2020021300263450000_REF23","doi-asserted-by":"crossref","unstructured":"Panaretou B, Prodromou C, Roe SM, et al. ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO J. 1998;17: 4829-4836.","DOI":"10.1093\/emboj\/17.16.4829"},{"key":"2020021300263450000_REF24","doi-asserted-by":"crossref","unstructured":"Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem. 1999;42: 260-266.","DOI":"10.1021\/jm980403y"},{"key":"2020021300263450000_REF25","doi-asserted-by":"crossref","unstructured":"Vogen S, Gidalevitz T, Biswas C, et al. Radicicol-sensitive peptide binding to the N-terminal portion of GRP94. J Biol Chem. 2002;277: 40742-40750.","DOI":"10.1074\/jbc.M205323200"},{"key":"2020021300263450000_REF26","doi-asserted-by":"crossref","unstructured":"Queitsch C, Sangster TA, Lindquist S. Hsp90 as a capacitor of phenotypic variation. Nature. 2002;417: 618-624.","DOI":"10.1038\/nature749"},{"key":"2020021300263450000_REF27","doi-asserted-by":"crossref","unstructured":"Mitchell-Olds T, Knight CA. Evolution: chaperones as buffering agents? Science. 2002;296: 2348-2349.","DOI":"10.1126\/science.1073846"},{"key":"2020021300263450000_REF28","doi-asserted-by":"crossref","unstructured":"Lipsker D, Ziylan U, Spehner D, et al. Heat shock proteins 70 and 60 share common receptors which are expressed on human monocyte-derived but not epidermal dendritic cells. Eur J Immunol. 2002;32: 322-332.","DOI":"10.1002\/1521-4141(200202)32:2<322::AID-IMMU322>3.0.CO;2-0"},{"key":"2020021300263450000_REF29","doi-asserted-by":"crossref","unstructured":"Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte\/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med. 1994;179: 1109-1118.","DOI":"10.1084\/jem.179.4.1109"},{"key":"2020021300263450000_REF30","doi-asserted-by":"crossref","unstructured":"Fulcher D, Wong S. Carboxyfluorescein succinimidyl ester-based proliferative assays for assessment of T cell function in the diagnostic laboratory. Immunol Cell Biol. 1999;77: 559-564.","DOI":"10.1046\/j.1440-1711.1999.00870.x"},{"key":"2020021300263450000_REF31","doi-asserted-by":"crossref","unstructured":"Langenkamp A, Messi M, Lanzavecchia A, Sallusto F. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol. 2000;1: 311-316.","DOI":"10.1038\/79758"},{"key":"2020021300263450000_REF32","doi-asserted-by":"crossref","unstructured":"Bunce M, O'Neill CM, Barnardo MC, et al. Photo-typing: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens. 1995;46: 355-367.","DOI":"10.1111\/j.1399-0039.1995.tb03127.x"},{"key":"2020021300263450000_REF33","doi-asserted-by":"crossref","unstructured":"Santin AD, Bellone S, Ravaggi A, et al. Induction of tumour-specific CD8(+) cytotoxic T lymphocytes by tumour lysate-pulsed autologous dendritic cells in patients with uterine serous papillary cancer. Br J Cancer. 2002;86: 151-157.","DOI":"10.1038\/sj.bjc.6600026"},{"key":"2020021300263450000_REF34","doi-asserted-by":"crossref","unstructured":"Somersan S, Larsson M, Fonteneau JF, Basu S, Srivastava P, Bhardwaj N. Primary tumor tissue lysates are enriched in heat shock proteins and induce the maturation of human dendritic cells. J Immunol. 2001;167: 4844-4852.","DOI":"10.4049\/jimmunol.167.9.4844"},{"key":"2020021300263450000_REF35","doi-asserted-by":"crossref","unstructured":"Young JW, Steinman RM. Accessory cell requirements for the mixed-leukocyte reaction and polyclonal mitogens, as studied with a new technique for enriching blood dendritic cells. Cell Immunol. 1988;111: 167-182.","DOI":"10.1016\/0008-8749(88)90061-5"},{"key":"2020021300263450000_REF36","doi-asserted-by":"crossref","unstructured":"Cook-Mozaffari P, Newton R, Beral V, Burkitt DP. The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic. Br J Cancer. 1998;78: 1521-1528.","DOI":"10.1038\/bjc.1998.717"},{"key":"2020021300263450000_REF37","doi-asserted-by":"crossref","unstructured":"Thomas JO. Acquired immunodeficiency syndrome-associated cancers in sub-Saharan Africa. Semin Oncol. 2001;28: 198-206.","DOI":"10.1016\/S0093-7754(01)90092-2"},{"key":"2020021300263450000_REF38","doi-asserted-by":"crossref","unstructured":"Lebbe C, Blum L, Pellet C, et al. Clinical and biological impact of antiretroviral therapy with protease inhibitors on HIV-related Kaposi's sarcoma. AIDS. 1998;12: F45-F49.","DOI":"10.1097\/00002030-199807000-00002"},{"key":"2020021300263450000_REF39","unstructured":"Jacobson LP, Yamashita TE, Detels R, et al. Impact of potent anti-retroviral therapy on the incidence of Kaposi's sarcoma and non-Hodgkin's lymphomas among HIV-1 infected individuals: Multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr. 1999;21(suppl 1): S34-S41."},{"key":"2020021300263450000_REF40","doi-asserted-by":"crossref","unstructured":"International Collaboration on HIV and Cancer. Highly active antiretroviral therapy and incidence of cancer in human immunodeficiency virus-infected adults. J Natl Cancer Inst. 2000;92: 1823-1830.","DOI":"10.1093\/jnci\/92.22.1823"},{"key":"2020021300263450000_REF41","doi-asserted-by":"crossref","unstructured":"Tirelli U, Bernardi D. Impact of HAART on the clinical management of AIDS-related cancers. Eur J Cancer. 2001;37: 1320-1324.","DOI":"10.1016\/S0959-8049(01)00106-X"},{"key":"2020021300263450000_REF42","doi-asserted-by":"crossref","unstructured":"Krown S, Metroka C, Wernz JC. Kaposi's sarcoma in the acquired immune deficiency syndrome: a proposal for uniform evaluation, response, and staging criteria: AIDS Clinical Trials Group Oncology Committee. J Clin Oncol. 1989;7: 1201-1207.","DOI":"10.1200\/JCO.1989.7.9.1201"},{"key":"2020021300263450000_REF43","doi-asserted-by":"crossref","unstructured":"Grassi F, Hosmalin A, McIlroy D, Calvez V, Debre P, Autran B. Depletion in blood CD11c-positive dendritic cells from HIV-infected patients. AIDS. 1999;13: 759-766.","DOI":"10.1097\/00002030-199905070-00004"},{"key":"2020021300263450000_REF44","doi-asserted-by":"crossref","unstructured":"Donaghy H, Pozniak A, Gazzard B, et al. Loss of blood CD11c(+) myeloid and CD11c(\u2013) plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load. Blood. 2001;98: 2574-2576.","DOI":"10.1182\/blood.V98.8.2574"},{"key":"2020021300263450000_REF45","doi-asserted-by":"crossref","unstructured":"Kanto T, Hayashi N, Takehara T, et al. Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol. 1999;162: 5584-5591.","DOI":"10.4049\/jimmunol.162.9.5584"},{"key":"2020021300263450000_REF46","doi-asserted-by":"crossref","unstructured":"Bain C, Fatmi A, Zoulim F, Zarski JP, Trepo C, Inchauspe G. Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology. 2001;120: 512-524.","DOI":"10.1053\/gast.2001.21212"},{"key":"2020021300263450000_REF47","doi-asserted-by":"crossref","unstructured":"Lu G, Janjic BM, Janjic J, Whiteside TL, Storkus WJ, Vujanovic NL. Innate direct anticancer effector function of human immature dendritic cells, II: role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand. J Immunol. 2002;168: 1831-1839.","DOI":"10.4049\/jimmunol.168.4.1831"},{"key":"2020021300263450000_REF48","doi-asserted-by":"crossref","unstructured":"Wilkinson J, Cope A, Gill J, et al. Identification of Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8)-specific cytotoxic T lymphocyte (CTL) epitopes and evaluation of reconstitution of KSHV-specific responses in HIV-1 infected patients receiving HAART. J Virol. 2002;76: 2634-2640.","DOI":"10.1128\/JVI.76.6.2634-2640.2002"},{"key":"2020021300263450000_REF49","doi-asserted-by":"crossref","unstructured":"Basu S, Srivastava PK. Calreticulin, a peptide-binding chaperone of the endoplasmic reticulum, elicits tumor- and peptide-specific immunity. J Exp Med. 1999;189: 797-802.","DOI":"10.1084\/jem.189.5.797"},{"key":"2020021300263450000_REF50","doi-asserted-by":"crossref","unstructured":"Penn I. Kaposi's sarcoma in organ transplant recipients: report of 20 cases. Transplantation. 1979;27: 8-11.","DOI":"10.1097\/00007890-197901000-00003"},{"key":"2020021300263450000_REF51","doi-asserted-by":"crossref","unstructured":"Mendez JC, Procop GW, Espy MJ, Smith TF, McGregor CG, Paya CV. Relationship of HHV8 replication and Kaposi's sarcoma after solid organ transplantation. Transplantation. 1999;67: 1200-1201.","DOI":"10.1097\/00007890-199904270-00022"},{"key":"2020021300263450000_REF52","doi-asserted-by":"crossref","unstructured":"Patterson S, Rae A, Hockey N, Gilmour J, Gotch F. Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus. J Virol. 2001;75: 6710-6713.","DOI":"10.1128\/JVI.75.14.6710-6713.2001"},{"key":"2020021300263450000_REF53","doi-asserted-by":"crossref","unstructured":"Hiroishi K, Tuting T, Lotze MT. IFN-alpha\u2013expressing tumor cells enhance generation and promote survival of tumor-specific CTLs. J Immunol. 2000;164: 567-572.","DOI":"10.4049\/jimmunol.164.2.567"},{"key":"2020021300263450000_REF54","doi-asserted-by":"crossref","unstructured":"Poli G, Orenstein JM, Kinter A, Folks TM, Fauci AS. Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell lines. Science. 1989;244: 575-577.","DOI":"10.1126\/science.2470148"},{"key":"2020021300263450000_REF55","doi-asserted-by":"crossref","unstructured":"Marrack P, Kappler J, Mitchell T. Type I interferons keep activated T cells alive. J Exp Med. 1999;189: 521-530.","DOI":"10.1084\/jem.189.3.521"},{"key":"2020021300263450000_REF56","doi-asserted-by":"crossref","unstructured":"Banerjee PP, Vinay DS, Mathew A, et al. Evidence that glycoprotein 96 (B2), a stress protein, functions as a Th2-specific costimulatory molecule. J Immunol. 2002;169: 3507-3518.","DOI":"10.4049\/jimmunol.169.7.3507"},{"key":"2020021300263450000_REF57","doi-asserted-by":"crossref","unstructured":"Delneste Y, Magistrelli G, Gauchat J, et al. Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity. 2002;17: 353-362.","DOI":"10.1016\/S1074-7613(02)00388-6"},{"key":"2020021300263450000_REF58","doi-asserted-by":"crossref","unstructured":"Lewthwaite JC, Coates AR, Tormay P, et al. Mycobacterium tuberculosis chaperonin 60.1 is a more potent cytokine stimulator than chaperonin 60.2 (Hsp 65) and contains a CD14-binding domain. Infect Immun. 2001;69: 7349-7355.","DOI":"10.1128\/IAI.69.12.7349-7355.2001"},{"key":"2020021300263450000_REF59","doi-asserted-by":"crossref","unstructured":"Vabulas RM, Braedel S, Hilf N, et al. The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2\/4 pathway. J Biol Chem. 2002;277: 20847-20853.","DOI":"10.1074\/jbc.M200425200"},{"key":"2020021300263450000_REF60","doi-asserted-by":"crossref","unstructured":"Berwin B, Hart JP, Pizzo SV, Nicchitta CV. Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides. J Immunol. 2002;168: 4282-4286.","DOI":"10.4049\/jimmunol.168.9.4282"},{"key":"2020021300263450000_REF61","doi-asserted-by":"crossref","unstructured":"Curry JL, Qin JZ, Bonish B, et al. Innate immunerelated receptors in normal and psoriatic skin. Arch Pathol Lab Med. 2003;127: 178-186.","DOI":"10.5858\/2003-127-178-IIRRIN"},{"key":"2020021300263450000_REF62","doi-asserted-by":"crossref","unstructured":"Liu Y, Jones M, Hingtgen CM, et al. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat Med. 2000;6: 1380-1387.","DOI":"10.1038\/82199"},{"key":"2020021300263450000_REF63","doi-asserted-by":"crossref","unstructured":"Nassar T, Akkawi S, Bar-Shavit R, et al. Human alpha-defensin regulates smooth muscle cell contraction: a role for low-density lipoprotein receptor-related protein\/alpha 2-macroglobulin receptor. Blood. 2002;100: 4026-4032.","DOI":"10.1182\/blood-2002-04-1080"},{"key":"2020021300263450000_REF64","doi-asserted-by":"crossref","unstructured":"Zhang L, Yu W, He T, et al. Contribution of human \u03b1\u2013defensin-1, -2 and -3 to the anti-HIV-1 activity of CD8 antiviral factor. Science. 2002;298: 995-1000.","DOI":"10.1126\/science.1076185"},{"key":"2020021300263450000_REF65","doi-asserted-by":"crossref","unstructured":"Stebbing J, Gazzard B, Kim L, et al. The heat shock protein receptor CD91 is upregulated in monocytes of HIV-1\u2013infected \u201ctrue\u201d long-term non-progressors. Blood. 2003;101: 4000-4004.","DOI":"10.1182\/blood-2002-11-3353"},{"key":"2020021300263450000_REF66","doi-asserted-by":"crossref","unstructured":"Rescigno M, Borrow P. The host-pathogen interaction: new themes from dendritic cell biology. Cell. 2001;106: 267-270.","DOI":"10.1016\/S0092-8674(01)00454-8"},{"key":"2020021300263450000_REF67","doi-asserted-by":"crossref","unstructured":"Huang Q, Liu D, Majewski P, et al. The plasticity of dendritic cell responses to pathogens and their components. Science. 2001;294: 870-875.","DOI":"10.1126\/science.294.5543.870"},{"key":"2020021300263450000_REF68","doi-asserted-by":"crossref","unstructured":"Triantafilou M, Miyake K, Golenbock DT, Triantafilou K. Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. J Cell Sci. 2002;115: 2603-2611.","DOI":"10.1242\/jcs.115.12.2603"},{"key":"2020021300263450000_REF69","doi-asserted-by":"crossref","unstructured":"Gurer C, Cimarelli A, Luban J. Specific incorporation of heat shock protein 70 family members into primate lentiviral virions. J Virol. 2002;76: 4666-4670.","DOI":"10.1128\/JVI.76.9.4666-4670.2002"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/102\/5\/1806\/1690491\/h81703001806.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/102\/5\/1806\/1690491\/h81703001806.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T09:04:21Z","timestamp":1682499861000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/102\/5\/1806\/17529\/Diseaseassociated-dendritic-cells-respond-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,1]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,9,1]]}},"URL":"https:\/\/doi.org\/10.1182\/blood-2003-03-0891","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,1]]}}}