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Constitutive expression of BRD2 in the lymphoid compartment increases cyclin A transcription, \u201cpriming\u201d transgenic B cells for proliferation. Mice stochastically develop an aggressive B-cell lymphoma with the features of B-1 cells, including CD5 and surface IgM expression. The B-cell lymphoma is monoclonal for immunoglobulin gene rearrangement and is phenotypically stable. The lymphoblasts are very large and express a transcriptome that is similar to human non-Hodgkin lymphomas. Both a wild-type BRD2 transgene and a kinase-null point mutant drive lymphomagenesis; therefore we propose that, rather than kinase activity, Brd2-mediated recruitment of E2 promoter binding factors (E2Fs) and a specific histone acetyltransferase to the cyclinA promoter by both types of transgene is a mechanistic basis for neoplasia. This report is the first to describe a transgenic mouse model for constitutive expression of a protein with more than one bromodomain.<\/jats:p>","DOI":"10.1182\/blood-2003-06-2116","type":"journal-article","created":{"date-parts":[[2003,10,21]],"date-time":"2003-10-21T00:22:21Z","timestamp":1066695741000},"page":"1475-1484","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":93,"title":["E\u03bc-BRD2 transgenic mice develop B-cell lymphoma and leukemia"],"prefix":"10.1182","volume":"103","author":[{"given":"Rebecca J.","family":"Greenwald","sequence":"first","affiliation":[{"name":"From the Department of Pathology, Immunology Research Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Immunobiology Unit, Departments of Medicine and Microbiology, Evans Biomedical Research Center, Boston Medical Center, Boston, MA; Cancer Research Center, Boston University School of Medicine, Boston, MA; and Center for Comparative Medicine, University of California at Davis, Davis, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Tumang","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Immunology Research Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Immunobiology Unit, Departments of Medicine and Microbiology, Evans Biomedical Research Center, Boston Medical Center, Boston, MA; Cancer Research Center, Boston University School of Medicine, Boston, MA; and Center for Comparative Medicine, University of California at Davis, Davis, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Sinha","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Immunology Research Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Immunobiology Unit, Departments of Medicine and Microbiology, Evans Biomedical Research Center, Boston Medical Center, Boston, MA; Cancer Research Center, Boston University School of Medicine, Boston, MA; and Center for Comparative Medicine, University of California at Davis, Davis, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Currier","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Immunology Research Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Immunobiology Unit, Departments of Medicine and Microbiology, Evans Biomedical Research Center, Boston Medical Center, Boston, MA; Cancer Research Center, Boston University School of Medicine, Boston, MA; and Center for Comparative Medicine, University of California at Davis, Davis, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Cardiff","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Immunology Research Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Immunobiology Unit, Departments of Medicine and Microbiology, Evans Biomedical Research Center, Boston Medical Center, Boston, MA; Cancer Research Center, Boston University School of Medicine, Boston, MA; and Center for Comparative Medicine, University of California at Davis, Davis, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Rothstein","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Immunology Research Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Immunobiology Unit, Departments of Medicine and Microbiology, Evans Biomedical Research Center, Boston Medical Center, Boston, MA; Cancer Research Center, Boston University School of Medicine, Boston, MA; and Center for Comparative Medicine, University of California at Davis, Davis, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas V.","family":"Faller","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Immunology Research Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Immunobiology Unit, Departments of Medicine and Microbiology, Evans Biomedical Research Center, Boston Medical Center, Boston, MA; Cancer Research Center, Boston University School of Medicine, Boston, MA; and Center for Comparative Medicine, University of California at Davis, Davis, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald V.","family":"Denis","sequence":"additional","affiliation":[{"name":"From the Department of Pathology, Immunology Research Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Immunobiology Unit, Departments of Medicine and Microbiology, Evans Biomedical Research Center, Boston Medical Center, Boston, MA; Cancer Research Center, Boston University School of Medicine, Boston, MA; and Center for Comparative Medicine, University of California at Davis, Davis, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021223321577000_REF1","doi-asserted-by":"crossref","unstructured":"Denis GV. 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