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Here, we report the overexpression of IL-7R\u03b1 that occurs in the early T-cell compartment from AKR\/J mice, animals that are highly susceptible to the spontaneous development of thymoma. Increased IL-7R\u03b1 was revealed by surface staining, and increased IL-7R\u03b1 mRNA was documented by using reverse transcriptase\u2013polymerase chain reaction (RT-PCR). This resulted in increased survival of AKR\/J early thymocytes, shown by the decreased frequency of TUNEL+ (terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate [dUTP]\u2013fluorescein nick end labeling) cells. In an in vivo thymocyte repopulation model, AKR\/J thymocytes had a selective advantage over healthy thymocytes. This advantage occurred at early stages of T-cell development. Our findings support the model that overexpression of growth factor receptors can contribute to proliferation and malignancy.<\/jats:p>","DOI":"10.1182\/blood-2003-06-2126","type":"journal-article","created":{"date-parts":[[2003,11,4]],"date-time":"2003-11-04T01:56:17Z","timestamp":1067910977000},"page":"1985-1994","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":40,"title":["Overexpression of IL-7R\u03b1 provides a competitive advantage during early T-cell development"],"prefix":"10.1182","volume":"103","author":[{"given":"Yasmina","family":"Laouar","sequence":"first","affiliation":[{"name":"From the Section of Immunobiology, Yale University School of Medicine, New Haven, CT; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY; and Howard Hughes Medical Institute, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Nicholas","family":"Crispe","sequence":"additional","affiliation":[{"name":"From the Section of Immunobiology, Yale University School of Medicine, New Haven, CT; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY; and Howard Hughes Medical Institute, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Flavell","sequence":"additional","affiliation":[{"name":"From the Section of Immunobiology, Yale University School of Medicine, New Haven, CT; David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY; and Howard Hughes Medical Institute, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021222345810200_REF1","doi-asserted-by":"crossref","unstructured":"Killeen N, Irving BA, Pippig S, Zingler K. Signaling checkpoints during the development of T lymphocytes. 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