{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:34:13Z","timestamp":1792679653217,"version":"4.5.0"},"reference-count":39,"publisher":"American Society of Hematology","issue":"5","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Edmonston vaccine strain of measles virus (MV-Edm) propagates efficiently in a broad range of human tumor cells, killing them selectively. However, the oncolytic potency of MV-Edm in different human tumor xenograft therapy models is highly variable and there is no convenient way to map the distribution of virus-infected tissues in vivo. To enhance the oncolytic potency of MV-Edm against radiosensitive malignancies and to facilitate noninvasive imaging of infected tissues, we generated a recombinant MV-Edm encoding the human thyroidal iodide symporter (NIS). MV-NIS replicated almost as efficiently as unmodified MV-Edm, and human tumor cells efficiently concentrated radioiodine when infected with MV-NIS. Intratumoral spread of MV-NIS was noninvasively demonstrated by serial gamma-camera imaging of iodine-123 (123I) uptake both in MV-sensitive KAS-6\/1 myeloma xenografts, which regressed completely after a single intravenous dose of MV-NIS, and in MM1 myeloma xenografts, which were unresponsive to MVNIS therapy. However, MV-resistant MM1 tumors regressed completely when 131I was administered 9 days after a single intravenous injection of MV-NIS (radiovirotherapy). 131I alone had no effect on MM1 tumor growth. While the potential hematopoietic toxicity of this new therapy requires further evaluation, image-guided radiovirotherapy is a promising new approach to the treatment of multiple myeloma, an incurable but highly radiosensitive plasma cell malignancy. Testing in other radiosensitive cancers is warranted.<\/jats:p>","DOI":"10.1182\/blood-2003-07-2233","type":"journal-article","created":{"date-parts":[[2003,11,11]],"date-time":"2003-11-11T01:13:36Z","timestamp":1068513216000},"page":"1641-1646","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":276,"title":["Image-guided radiovirotherapy for multiple myeloma using a recombinant measles virus expressing the thyroidal sodium iodide symporter"],"prefix":"10.1182","volume":"103","author":[{"given":"David","family":"Dingli","sequence":"first","affiliation":[{"name":"From the Molecular Medicine Program, the Division of Hematology and Internal Medicine, the Department of Radiology, and the Division of Endocrinology and Metabolism, Mayo Clinic and Foundation, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kah-Whye","family":"Peng","sequence":"additional","affiliation":[{"name":"From the Molecular Medicine Program, the Division of Hematology and Internal Medicine, the Department of Radiology, and the Division of Endocrinology and Metabolism, Mayo Clinic and Foundation, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Harvey","sequence":"additional","affiliation":[{"name":"From the Molecular Medicine Program, the Division of Hematology and Internal Medicine, the Department of Radiology, and the Division of Endocrinology and Metabolism, Mayo Clinic and Foundation, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Greipp","sequence":"additional","affiliation":[{"name":"From the Molecular Medicine Program, the Division of Hematology and Internal Medicine, the Department of Radiology, and the Division of Endocrinology and Metabolism, Mayo Clinic and Foundation, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"From the Molecular Medicine Program, the Division of Hematology and Internal Medicine, the Department of Radiology, and the Division of Endocrinology and Metabolism, Mayo Clinic and Foundation, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"From the Molecular Medicine Program, the Division of Hematology and Internal Medicine, the Department of Radiology, and the Division of Endocrinology and Metabolism, Mayo Clinic and Foundation, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[{"name":"From the Molecular Medicine Program, the Division of Hematology and Internal Medicine, the Department of Radiology, and the Division of Endocrinology and Metabolism, Mayo Clinic and Foundation, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Russell","sequence":"additional","affiliation":[{"name":"From the Molecular Medicine Program, the Division of Hematology and Internal Medicine, the Department of Radiology, and the Division of Endocrinology and Metabolism, Mayo Clinic and Foundation, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021218091280500_REF1","doi-asserted-by":"crossref","unstructured":"Bataille R, Harousseau JL. 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