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Cancer diagnoses from 1958 to 1998 were assessed in 14 336 first-degree relatives of 5918 CLL cases and in 28 876 first-degree relatives of 11 778 controls. Cancer risks in relatives of cases were compared with those in relatives of controls using marginal survival models. Relatives of cases were at significantly increased risk for CLL (relative risk [RR] = 7.52; 95% confidence interval [CI], 3.63-15.56), for non-Hodgkin lymphoma (RR = 1.45; 95% CI, 0.98-2.16), and for Hodgkin lymphoma (RR = 2.35; 95% CI, 1.08-5.08). CLL risks were similar in parents, siblings, and offspring of cases, in male and female relatives, and were not affected by the case's age at diagnosis. Anticipation was not significant when analyzed using life table methods. We conclude that the familial component of CLL is shared with other lymphoproliferative malignances, suggesting common genetic pathways. However, because clinically diagnosed CLL is uncommon, absolute excess risk to relatives is small.<\/jats:p>","DOI":"10.1182\/blood-2004-01-0341","type":"journal-article","created":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:13:21Z","timestamp":1086048801000},"page":"1850-1854","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":168,"title":["Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database"],"prefix":"10.1182","volume":"104","author":[{"given":"Lynn R.","family":"Goldin","sequence":"first","affiliation":[{"name":"From the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI); Biostatistics Branch, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, MD; Department of Biosciences at Novum, Karolinska Institute, Stockholm, Sweden; and Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth M.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"From the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI); Biostatistics Branch, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, MD; Department of Biosciences at Novum, Karolinska Institute, Stockholm, Sweden; and Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Li","sequence":"additional","affiliation":[{"name":"From the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI); Biostatistics Branch, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, MD; Department of Biosciences at Novum, Karolinska Institute, Stockholm, Sweden; and Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Hemminki","sequence":"additional","affiliation":[{"name":"From the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI); Biostatistics Branch, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, MD; Department of Biosciences at Novum, Karolinska Institute, Stockholm, Sweden; and Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021223563556100_REF1","unstructured":"Ries LAG, Eisner MP, Kosary CL, et al, eds. 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