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This result is consistent with the clinical observation that SAO individuals can experience high-density P falciparum infections and provides an explanation for previous discrepant results on invasion of SAO RBCs. Characterization of the invasion phenotype of 3D7-A revealed that efficient invasion of SAO RBCs was paralleled by relatively efficient invasion of normal RBCs treated with either neuraminidase, trypsin, or chymotrypsin and a novel capacity to invade normal RBCs treated sequentially with both neuraminidase and trypsin. Our results suggest that only parasites able to use some particular invasion pathways can invade SAO RBCs efficiently in culture. A similar situation might occur in the field.<\/jats:p>","DOI":"10.1182\/blood-2004-06-2136","type":"journal-article","created":{"date-parts":[[2004,7,21]],"date-time":"2004-07-21T01:12:04Z","timestamp":1090372324000},"page":"2961-2966","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":58,"title":["Ability of Plasmodium falciparum to invade Southeast Asian ovalocytes varies between parasite lines"],"prefix":"10.1182","volume":"104","author":[{"given":"Alfred","family":"Corte\u0301s","sequence":"first","affiliation":[{"name":"From the Molecular Parasitology Laboratory, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea; Department of Microbiology, Monash University, Victoria, Australia; Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Chamblee, GA; and Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"Benet","sequence":"additional","affiliation":[{"name":"From the Molecular Parasitology Laboratory, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea; Department of Microbiology, Monash University, Victoria, Australia; Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Chamblee, GA; and Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Cooke","sequence":"additional","affiliation":[{"name":"From the Molecular Parasitology Laboratory, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea; Department of Microbiology, Monash University, Victoria, Australia; Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Chamblee, GA; and Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Barnwell","sequence":"additional","affiliation":[{"name":"From the Molecular Parasitology Laboratory, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea; Department of Microbiology, Monash University, Victoria, Australia; Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Chamblee, GA; and Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Reeder","sequence":"additional","affiliation":[{"name":"From the Molecular Parasitology Laboratory, Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea; Department of Microbiology, Monash University, Victoria, Australia; Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Chamblee, GA; and Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2020021223253755800_REF1","doi-asserted-by":"crossref","unstructured":"Dolan SA, Proctor JL, Alling DW, Okubo Y, Wellems TE, Miller LH. 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