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Lymphomagenesis requires Rag activity, which peaks at this developmental stage, as well as additional secondary genetic events. A consistent secondary event is the transcriptional up-regulation of c-Myc, whose activity is required for transformation because its conditional ablation abrogates lymphomagenesis. In contrast, the expression of Notch receptors as well as targets is reduced in DP thymocytes with stabilized \u03b2-catenin and remains low in the lymphomas, indicating that Notch activation is not required or selected for in \u03b2-catenin\u2013induced lymphomas. Thus, \u03b2-catenin activation may provide a mechanism for the induction of T-cell\u2013acute lymphoblastic leukemia (T-ALL) that does not depend on Notch activation.<\/jats:p>","DOI":"10.1182\/blood-2006-11-059071","type":"journal-article","created":{"date-parts":[[2007,2,23]],"date-time":"2007-02-23T01:43:55Z","timestamp":1172195035000},"page":"5463-5472","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":110,"title":["\u03b2-Catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation"],"prefix":"10.1182","volume":"109","author":[{"given":"Zhuyan","family":"Guo","sequence":"first","affiliation":[{"name":"Molecular Oncology Research Institute, Tufts-New England Medical Center, Boston;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marei","family":"Dose","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Institute, Tufts-New England Medical Center, Boston;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Kovalovsky","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Institute, Tufts-New England Medical Center, Boston;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Chang","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Institute, Tufts-New England Medical Center, Boston;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"O'Neil","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute, Harvard Medical School, Boston;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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