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To test this hypothesis, we generated chimeric mice by transplantation of clonal populations of cells derived from single enhanced green fluorescent protein (EGFP)\u2013marked Lin\u2212Sca-1+c-kit+CD34\u2212 cells and examined the histology of liver tissues obtained from the chimeric mice with carbon tetrachloride (CCl4)\u2013induced injury. After 12 weeks of CCl4 treatment, we detected EGFP+ cells in the liver, and some cells contained intracytoplasmic lipid droplets. Immunofluorescence analysis demonstrated that 50% to 60% of the EGFP+ cells were negative for CD45 and positive for vimentin, glial fibrillary acidic protein, ADAMTS13, and \u03b1-smooth muscle actin. Moreover, EGFP+ cells isolated from the liver synthesized collagen I in culture. These phenotypes were consistent with those of hepatic stellate cells. The hematopoietic stem cell\u2013derived hepatic stellate cells seen in male-to-male transplants revealed only one Y chromosome. Our findings suggest that hematopoietic stem cells contribute to the generation of hepatic stellate cells after liver injury and that the process does not involve cell fusion.<\/jats:p>","DOI":"10.1182\/blood-2007-07-101261","type":"journal-article","created":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T01:53:48Z","timestamp":1196214828000},"page":"2427-2435","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":78,"title":["Hematopoietic origin of hepatic stellate cells in the adult liver"],"prefix":"10.1182","volume":"111","author":[{"given":"Eri","family":"Miyata","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Masuya","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu;"},{"name":"Blood Transfusion Service, Mie University Hospital, Tsu; 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