{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:20:48Z","timestamp":1793409648583,"version":"4.5.0"},"reference-count":35,"publisher":"American Society of Hematology","issue":"12","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rare cases of histiocytic and dendritic cell (H\/DC) neoplasms have been reported in patients with follicular lymphoma (FL), but the biologic relationship between the 2 neoplasms is unknown. We studied 8 patients with both FL and H\/DC neoplasms using immunohistochemistry, fluorescence in situ hybridization (FISH) for t(14;18), and polymerase chain reaction (PCR)\/sequencing of BCL2 and IGH rearrangements. There were 5 men and 3 women (median age, 59 years). All cases of FL were positive for t(14;18). The H\/DC tumors included 7 histiocytic sarcomas, 5 of which showed evidence of dendritic differentiation, and 1 interdigitating cell sarcoma. Five H\/DC tumors were metachronous, following FL by 2 months to 12 years; tumors were synchronous in 3. All 8 H\/DC tumors showed presence of the t(14;18) either by FISH, or in 2 cases by PCR with the major breakpoint region (MBR) probe. PCR and sequencing identified identical IGH gene rearrangements or BCL2 gene breakpoints in all patients tested. All H\/DC tumors lacked PAX5, and up-regulation of CEBP\u03b2 and PU.1 was seen in all cases tested. These results provide evidence for a common clonal origin of FL and H\/DC neoplasms when occurring in the same patient, and suggest that lineage plasticity may occur in mature lymphoid neoplasms.<\/jats:p>","DOI":"10.1182\/blood-2007-11-124792","type":"journal-article","created":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T21:25:06Z","timestamp":1202937906000},"page":"5433-5439","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":291,"title":["Clonally related follicular lymphomas and histiocytic\/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone"],"prefix":"10.1182","volume":"111","author":[{"given":"Andrew L.","family":"Feldman","sequence":"first","affiliation":[{"name":"Laboratory of Pathology, National Cancer Institute, Bethesda, MD;"},{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Arber","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University, Stanford, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Pittaluga","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, National Cancer Institute, Bethesda, MD;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Martinez","sequence":"additional","affiliation":[{"name":"University of Barcelona, Barcelona, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome S.","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Pathology, Alta Bates Summit Medical Center, Berkeley, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Raffeld","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, National Cancer Institute, Bethesda, MD;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Camos","sequence":"additional","affiliation":[{"name":"University of Barcelona, Barcelona, Spain; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Warnke","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University, Stanford, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine S.","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, National Cancer Institute, Bethesda, MD;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2019111713534738900_B1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35004599","article-title":"A clonogenic common myeloid progenitor that gives rise to all myeloid lineages.","volume":"404","author":"Akashi","year":"2000","journal-title":"Nature"},{"key":"2019111713534738900_B2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0952-7915(99)00064-3","article-title":"Lymphoid precursors.","volume":"12","author":"Akashi","year":"2000","journal-title":"Curr Opin Immunol"},{"key":"2019111713534738900_B3","article-title":"Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues.","author":"Jaffe","year":"2001"},{"key":"2019111713534738900_B4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S1470-2045(05)70211-4","article-title":"Clonal relationship between precursor T-lymphoblastic leukaemia\/lymphoma and Langerhans-cell histiocytosis.","volume":"6","author":"Feldman","year":"2005","journal-title":"Lancet Oncol"},{"key":"2019111713534738900_B5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S1470-2045(04)01428-7","article-title":"Histiocytic sarcoma after acute lymphoblastic leukaemia: a common clonal origin.","volume":"5","author":"Feldman","year":"2004","journal-title":"Lancet Oncol"},{"key":"2019111713534738900_B6","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1182\/blood-2002-07-2085","article-title":"In vitro identification of human pro-B cells that give rise to macrophages, natural killer cells, and T cells.","volume":"101","author":"Reynaud","year":"2003","journal-title":"Blood"},{"key":"2019111713534738900_B7","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/ajcp\/104.6.696","article-title":"Dendritic cell tumors associated with low-grade B-cell malignancies: report of three cases.","volume":"104","author":"Vasef","year":"1995","journal-title":"Am J Clin Pathol"},{"key":"2019111713534738900_B8","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3109\/01913129109023193","article-title":"Interdigitating reticulum cell sarcoma with unusual features.","volume":"15","author":"Hammar","year":"1991","journal-title":"Ultrastruct Pathol"},{"key":"2019111713534738900_B9","doi-asserted-by":"crossref","first-page":"544","DOI":"10.5858\/2006-130-544-SIDCSA","article-title":"Synchronous interdigitating dendritic cell sarcoma and B-cell small lymphocytic lymphoma in a lymph node.","volume":"130","author":"Cossu","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"2019111713534738900_B10","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1309\/M95G-7DQ2-TLQL-7Q11","article-title":"Interdigitating dendritic cell sarcoma: a report of four cases and review of the literature.","volume":"115","author":"Gaertner","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"2019111713534738900_B11","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/1097-0142(19950815)76:4<609::AID-CNCR2820760411>3.0.CO;2-Y","article-title":"Transformation of chronic lymphocytic leukemia to lymphoma of true histiocytic type.","volume":"76","author":"Wetzler","year":"1995","journal-title":"Cancer"},{"key":"2019111713534738900_B12","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1097\/00000478-199611000-00013","article-title":"True histiocytic lymphoma of the stomach associated with low-grade B-cell mucosa-associated lymphoid tissue (MALT)-type lymphoma.","volume":"20","author":"Alvaro","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"2019111713534738900_B13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00000478-198309000-00003","article-title":"Langerhans' cell granulomatosis (histiocytosis X) associated with malignant lymphomas.","volume":"7","author":"Burns","year":"1983","journal-title":"Am J Surg Pathol"},{"key":"2019111713534738900_B14","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/S0046-8177(86)80091-0","article-title":"The coexistence of Langerhans' cell granulomatosis and malignant lymphoma may take different forms: report of seven cases with a review of the literature.","volume":"17","author":"Neumann","year":"1986","journal-title":"Hum Pathol"},{"key":"2019111713534738900_B15","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0889-8588(05)70516-5","article-title":"The relation of Langerhans cell histiocytosis to acute leukemia, lymphomas, and other solid tumors: the LCH-Malignancy Study Group of the Histiocyte Society.","volume":"12","author":"Egeler","year":"1998","journal-title":"Hematol Oncol Clin North Am"},{"key":"2019111713534738900_B16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2559.2002.01418.x","article-title":"Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases.","volume":"41","author":"Pileri","year":"2002","journal-title":"Histopathology"},{"key":"2019111713534738900_B17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1136\/jcp.2003.015537","article-title":"Langerhans cell histiocytosis in sequential discordant lymphoma.","volume":"58","author":"Adu-Poku","year":"2005","journal-title":"J Clin Pathol"},{"key":"2019111713534738900_B18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/ajcp\/85.1.111","article-title":"Composite lymphoma with immunoblastic features and Langerhans' cell granulomatosis (histiocytosis X).","volume":"85","author":"Almanaseer","year":"1986","journal-title":"Am J Clin Pathol"},{"key":"2019111713534738900_B19","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0145-2126(02)00009-7","article-title":"Identical rearrangement of immunoglobulin heavy chain gene in neoplastic Langerhans cells and B-lymphocytes: evidence for a common precursor.","volume":"26","author":"Magni","year":"2002","journal-title":"Leuk Res"},{"key":"2019111713534738900_B20","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1182\/blood.V96.5.1633","article-title":"Langerhans cells develop from a lymphoid-committed precursor.","volume":"96","author":"Anju\u00e8re","year":"2000","journal-title":"Blood"},{"key":"2019111713534738900_B21","first-page":"33","article-title":"Qiagen.","volume-title":"QIAamp DNA Mini and Blood Mini Handbook","year":"2003"},{"key":"2019111713534738900_B22","unstructured":"Kyoto University Bioinformatics Center CLUSTALW. Accessed July 25, 2006 http:\/\/clustalw.genome.jp\/"},{"key":"2019111713534738900_B23","doi-asserted-by":"crossref","first-page":"W435","DOI":"10.1093\/nar\/gkh412","article-title":"IMGT\/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis.","volume":"32","author":"Giudicelli","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"2019111713534738900_B24","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ni1454","article-title":"Pax5: the guardian of B cell identity and function.","volume":"8","author":"Cobaleda","year":"2007","journal-title":"Nat Immunol"},{"key":"2019111713534738900_B25","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0092-8674(04)00419-2","article-title":"Stepwise reprogramming of B cells into macrophages.","volume":"117","author":"Xie","year":"2004","journal-title":"Cell"},{"key":"2019111713534738900_B26","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1182\/blood-2002-06-1797","article-title":"Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing\/reactivation of the EBF\/Pax5 pathway.","volume":"101","author":"Yu","year":"2003","journal-title":"Blood"},{"key":"2019111713534738900_B27","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nature06159","article-title":"Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors.","volume":"449","author":"Cobaleda","year":"2007","journal-title":"Nature"},{"key":"2019111713534738900_B28","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1038\/sj.emboj.7600421","article-title":"Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible.","volume":"23","author":"Tagoh","year":"2004","journal-title":"EMBO J"},{"key":"2019111713534738900_B29","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1056\/NEJMoa033153","article-title":"Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas.","volume":"351","author":"Streubel","year":"2004","journal-title":"N Engl J Med"},{"key":"2019111713534738900_B30","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nature729","article-title":"Changing potency by spontaneous fusion.","volume":"416","author":"Ying","year":"2002","journal-title":"Nature"},{"key":"2019111713534738900_B31","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1182\/blood.V93.11.3956","article-title":"Horizontal transfer of DNA by the uptake of apoptotic bodies.","volume":"93","author":"Holmgren","year":"1999","journal-title":"Blood"},{"key":"2019111713534738900_B32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/83210","article-title":"Bipotential B-macrophage progenitors are present in adult bone marrow.","volume":"2","author":"Montecino-Rodriguez","year":"2001","journal-title":"Nat Immunol"},{"key":"2019111713534738900_B33","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1182\/blood-2004-07-2839","article-title":"Identification of a human B-cell\/myeloid common progenitor by the absence of CXCR4.","volume":"105","author":"Hou","year":"2005","journal-title":"Blood"},{"key":"2019111713534738900_B34","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1126\/science.3929382","article-title":"The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining.","volume":"229","author":"Tsujimoto","year":"1985","journal-title":"Science"},{"key":"2019111713534738900_B35","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature02355","article-title":"A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex.","volume":"428","author":"Raghavan","year":"2004","journal-title":"Nature"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/111\/12\/5433\/1298025\/zh801208005433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/111\/12\/5433\/1298025\/zh801208005433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T02:59:33Z","timestamp":1630724373000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/111\/12\/5433\/23798\/Clonally-related-follicular-lymphomas-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,15]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,6,15]]}},"URL":"https:\/\/doi.org\/10.1182\/blood-2007-11-124792","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1119232.575397","asserted-by":"object"}]},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,15]]}}}