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Genetic disruption of SHP2 or treatment of oncogene-bearing cells with a novel SHP2 inhibitor alone or in combination with the PI3K inhibitor corrects MPD by disrupting a protein complex involving p85\u03b1, SHP2, and Gab2. Importantly, a single tyrosine at position 719 in oncogenic KIT is sufficient to develop MPD by recruiting p85\u03b1, SHP2, and Gab2 complex to oncogenic KIT. Our results demonstrate that SHP2 phosphatase is a druggable target that cooperates with lipid kinases in inducing MPD.<\/jats:p>","DOI":"10.1182\/blood-2011-08-375873","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T08:09:57Z","timestamp":1342685397000},"page":"2669-2678","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":48,"title":["Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT"],"prefix":"10.1182","volume":"120","author":[{"given":"Raghuveer Singh","family":"Mali","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Herman B. Wells Center for Pediatric Research and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Herman B. 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