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By using such approaches in patients with unexplained anemias, we have discovered that a broad range of hitherto unrelated human red cell disorders are caused by variants in KLF1, a master regulator of erythropoiesis, which were previously considered to be extremely rare causes of human genetic disease.<\/jats:p>","DOI":"10.1182\/blood-2016-01-694331","type":"journal-article","created":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T04:13:48Z","timestamp":1456200828000},"page":"1856-1862","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":161,"title":["Kr\u00fcppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants"],"prefix":"10.1182","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3644-7093","authenticated-orcid":false,"given":"Andrew","family":"Perkins","sequence":"first","affiliation":[{"name":"Mater Research Institute, University of Queensland, 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