{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:14:21Z","timestamp":1776154461744,"version":"3.50.1"},"reference-count":104,"publisher":"American Society of Hematology","issue":"19","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22\u2009423 control patients. We identify 5 new HL risk loci at 6p21.31 (rs649775; P = 2.11 \u00d7 10\u221210), 6q23.3 (rs1002658; P = 2.97 \u00d7 10\u22128), 11q23.1 (rs7111520; P = 1.44 \u00d7 10\u221211), 16p11.2 (rs6565176; P = 4.00 \u00d7 10\u22128), and 20q13.12 (rs2425752; P = 2.01 \u00d7 10\u22128). Integration of gene expression, histone modification, and in situ promoter capture Hi-C data at the 5 new and 13 known risk loci implicates dysfunction of the germinal center reaction, disrupted T-cell differentiation and function, and constitutive NF-\u03baB activation as mechanisms of predisposition. These data provide further insights into the genetic susceptibility and biology of HL.<\/jats:p>","DOI":"10.1182\/blood-2018-06-855296","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T16:26:05Z","timestamp":1536337565000},"page":"2040-2052","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":23,"title":["Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma"],"prefix":"10.1182","volume":"132","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6133-0164","authenticated-orcid":false,"given":"Amit","family":"Sud","sequence":"first","affiliation":[{"name":"Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5951-3116","authenticated-orcid":false,"given":"Hauke","family":"Thomsen","sequence":"first","affiliation":[{"name":"Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Orlando","sequence":"first","affiliation":[{"name":"Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asta","family":"F\u00f6rsti","sequence":"first","affiliation":[{"name":"Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany;"},{"name":"Center for Primary Health Care Research, Lund University, Malm\u00f6, Sweden;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9663-4611","authenticated-orcid":false,"given":"Philip J.","family":"Law","sequence":"first","affiliation":[{"name":"Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8348-5829","authenticated-orcid":false,"given":"Peter","family":"Broderick","sequence":"first","affiliation":[{"name":"Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosie","family":"Cooke","sequence":"first","affiliation":[{"name":"Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi","family":"Hariri","sequence":"first","affiliation":[{"name":"Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, McGill University, Montreal, QC, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4016-5021","authenticated-orcid":false,"given":"Tomi","family":"Pastinen","sequence":"first","affiliation":[{"name":"Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, McGill University, Montreal, QC, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas F.","family":"Easton","sequence":"first","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Oncology, and"},{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8494-732X","authenticated-orcid":false,"given":"Paul D. 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