{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:37:56Z","timestamp":1790185076160,"version":"4.1.0"},"reference-count":52,"publisher":"American Society of Hematology","issue":"3","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Efficient migration of macrophages to sites of inflammation requires cell surface\u2013bound plasmin(ogen). Here, we investigated the mechanisms underlying the deficits of plasmin(ogen)-mediated macrophage migration in 2 models: murine thioglycollate-induced peritonitis and in vitro macrophage migration. As previously reported, macrophage migration into the peritoneal cavity of mice in response to thioglycollate was significantly impaired in the absence of plasminogen. Fibrin(ogen) deposition was noted in the peritoneal cavity in response to thioglycollate, with a significant increase in fibrin(ogen) in the plasminogen-deficient mice. Interestingly, macrophage migration was restored in plasminogen-deficient mice by simultaneous imposition of fibrinogen deficiency. Consistent with this in vivo finding, chemotactic migration of cultured macrophages through a fibrin matrix did not occur in the absence of plasminogen. The macrophage requirement for plasmin-mediated fibrinolysis, both in vivo and in vitro, was negated by deletion of the major myeloid integrin \u03b1M\u03b22-binding motif on the \u03b3 chain of fibrin(ogen). The study identifies a critical role of fibrinolysis in macrophage migration, presumably through the alleviation of migratory constraints imposed by the interaction of leukocytes with fibrin(ogen) through the integrin \u03b1M\u03b22 receptor.<\/jats:p>","DOI":"10.1182\/blood.2018874859","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T22:24:06Z","timestamp":1558131846000},"page":"291-303","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":42,"title":["Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation"],"prefix":"10.1182","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6282-2657","authenticated-orcid":false,"given":"Lakmali Munasinghage","family":"Silva","sequence":"first","affiliation":[{"name":"Proteases and Tissue Remodeling Section and"},{"name":"Oral Inflammation and Immunity Unit, National Institute of Dental and Craniofacial 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