{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:53:59Z","timestamp":1787500439856,"version":"build-2736575974"},"reference-count":84,"publisher":"American Society of Hematology","issue":"16","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,10,17]]},"abstract":"<jats:title>Key Points<\/jats:title>\n                  <jats:p>The cyclic resveratrol trimer caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells. Caraphenol A decreases interferon-induced transmembrane protein-mediated restriction in an endosomal trafficking-dependent manner.<\/jats:p>","DOI":"10.1182\/blood.2019000040","type":"journal-article","created":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T19:44:01Z","timestamp":1565898241000},"page":"1298-1311","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":33,"title":["Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes"],"prefix":"10.1182","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2120-9140","authenticated-orcid":false,"given":"Stosh","family":"Ozog","sequence":"first","affiliation":[{"name":"The Scripps Research Institute, La Jolla, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina D.","family":"Timberlake","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute, La Jolla, CA;"},{"name":"Poseida Therapeutics, San Diego, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kip","family":"Hermann","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute, La Jolla, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Garijo","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute, La Jolla, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Haworth","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoli","family":"Shi","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Frederick, MD;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Glinkerman","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute, La Jolla, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Schefter","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9827-9622","authenticated-orcid":false,"given":"Saritha","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"Wisconsin National Primate Research Center, Madison, WI;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Simpson","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute, La Jolla, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Sghia-Hughes","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond R.","family":"Carillo","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale L.","family":"Boger","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute, La Jolla, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5949-4947","authenticated-orcid":false,"given":"Hans-Peter","family":"Kiem","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center, Seattle, WA;"},{"name":"University of Washington, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Slukvin","sequence":"additional","affiliation":[{"name":"Wisconsin National Primate Research Center, Madison, WI;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Y.","family":"Ryu","sequence":"additional","affiliation":[{"name":"St. Jude Children\u2019s Research Hospital, Memphis, TN;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P.","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"St. Jude Children\u2019s Research Hospital, Memphis, TN;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4599-016X","authenticated-orcid":false,"given":"Jennifer E.","family":"Adair","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center, Seattle, WA;"},{"name":"University of Washington, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3594-8769","authenticated-orcid":false,"given":"Scott A.","family":"Snyder","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute, Jupiter, FL; and"},{"name":"University of Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7508-4953","authenticated-orcid":false,"given":"Alex A.","family":"Compton","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Frederick, MD;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4995-1694","authenticated-orcid":false,"given":"Bruce E.","family":"Torbett","sequence":"additional","affiliation":[{"name":"The Scripps Research Institute, La Jolla, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","published-online":{"date-parts":[[2019,8,15]]},"reference":[{"issue":"5","key":"2019111521005198400_B1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1056\/NEJMoa0805817","article-title":"Gene therapy for immunodeficiency due to adenosine deaminase deficiency","volume":"360","author":"Aiuti","year":"2009","journal-title":"N Engl J Med"},{"issue":"6148","key":"2019111521005198400_B2","doi-asserted-by":"crossref","first-page":"1233151","DOI":"10.1126\/science.1233151","article-title":"Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome","volume":"341","author":"Aiuti","year":"2013","journal-title":"Science"},{"issue":"6148","key":"2019111521005198400_B3","doi-asserted-by":"crossref","first-page":"1233158","DOI":"10.1126\/science.1233158","article-title":"Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy","volume":"341","author":"Biffi","year":"2013","journal-title":"Science"},{"issue":"22","key":"2019111521005198400_B4","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1182\/blood.V128.22.3510.3510","article-title":"Gene therapy for Fanconi anemia in Seattle: Clinical experience and next steps","volume":"128","author":"Adair","year":"2016","journal-title":"Blood"},{"issue":"16","key":"2019111521005198400_B5","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1056\/NEJMoa1705342","article-title":"Gene therapy in patients with transfusion-dependent \u03b2-thalassemia","volume":"378","author":"Thompson","year":"2018","journal-title":"N Engl J Med"},{"issue":"9","key":"2019111521005198400_B6","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1056\/NEJMoa1609677","article-title":"Gene therapy in a patient with sickle cell disease","volume":"376","author":"Ribeil","year":"2017","journal-title":"N Engl J Med"},{"issue":"5","key":"2019111521005198400_B7","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.ymthe.2017.03.025","article-title":"Hematopoietic stem cell gene therapy for storage disease: current and new indications","volume":"25","author":"Biffi","year":"2017","journal-title":"Mol Ther"},{"key":"2019111521005198400_B8","doi-asserted-by":"crossref","first-page":"16034","DOI":"10.1038\/mtm.2016.34","article-title":"Clinical development of gene therapy: results and lessons from recent successes","volume":"3","author":"Kumar","year":"2016","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"11","key":"2019111521005198400_B9","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1182\/blood-2005-10-4047","article-title":"Proteasome activity restricts lentiviral gene transfer into hematopoietic stem cells and is down-regulated by cytokines that enhance transduction","volume":"107","author":"Santoni de Sio","year":"2006","journal-title":"Blood"},{"issue":"5","key":"2019111521005198400_B10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S1525-0016(02)90720-3","article-title":"Molecular evidence of lentiviral vector-mediated gene transfer into human self-renewing, multi-potent, long-term NOD\/SCID repopulating hematopoietic cells","volume":"6","author":"Ailles","year":"2002","journal-title":"Mol Ther"},{"issue":"2","key":"2019111521005198400_B11","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1182\/blood-2003-05-1558","article-title":"Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment","volume":"103","author":"Mazurier","year":"2004","journal-title":"Blood"},{"issue":"8","key":"2019111521005198400_B12","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1182\/blood-2014-02-558163","article-title":"Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCs","volume":"124","author":"Girard-Gagnepain","year":"2014","journal-title":"Blood"},{"issue":"23","key":"2019111521005198400_B13","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1182\/bloodadvances.2017007773","article-title":"Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent","volume":"1","author":"L\u00e9vy","year":"2017","journal-title":"Blood Adv"},{"key":"2019111521005198400_B84","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.omtm.2018.11.006","article-title":"CD46 null packaging cell line improves measles lentiviral vector production and gene delivery to hematopoietic stem and progenitor cells","volume":"13","author":"Ozog","year":"2019","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"6","key":"2019111521005198400_B14","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1182\/blood-2013-12-546218","article-title":"Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells","volume":"124","author":"Wang","year":"2014","journal-title":"Blood"},{"issue":"1","key":"2019111521005198400_B15","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ymthe.2017.09.025","article-title":"Prostaglandin E2 increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells","volume":"26","author":"Heffner","year":"2018","journal-title":"Mol Ther"},{"issue":"6","key":"2019111521005198400_B16","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.stem.2018.10.008","article-title":"Cyclosporine H Overcomes innate immune restrictions to improve lentiviral transduction and gene editing in human hematopoietic stem cells","volume":"23","author":"Petrillo","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"4","key":"2019111521005198400_B17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1089\/hum.2015.036","article-title":"Cellular innate immunity and restriction of viral infection: implications for lentiviral gene therapy in human hematopoietic cells","volume":"26","author":"Kajaste-Rudnitski","year":"2015","journal-title":"Hum Gene Ther"},{"issue":"9","key":"2019111521005198400_B18","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1182\/blood-2013-11-540641","article-title":"Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor","volume":"123","author":"Amirache","year":"2014","journal-title":"Blood"},{"issue":"1","key":"2019111521005198400_B19","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1128\/JVI.73.1.728-737.1999","article-title":"Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite coreceptor expression","volume":"73","author":"Shen","year":"1999","journal-title":"J Virol"},{"issue":"2","key":"2019111521005198400_B20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1172\/JCI28971","article-title":"Primitive hematopoietic cells resist HIV-1 infection via p21","volume":"117","author":"Zhang","year":"2007","journal-title":"J Clin Invest"},{"issue":"3","key":"2019111521005198400_B21","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jcyt.2015.12.007","article-title":"Ex vivo virotherapy with myxoma virus does not impair hematopoietic stem and progenitor cells","volume":"18","author":"Villa","year":"2016","journal-title":"Cytotherapy"},{"issue":"15","key":"2019111521005198400_B22","doi-asserted-by":"crossref","first-page":"8096","DOI":"10.1128\/JVI.01044-15","article-title":"HIV-1 is restricted prior to integration of viral DNA in primary cord-derived human CD34+ cells","volume":"89","author":"Griffin","year":"2015","journal-title":"J Virol"},{"issue":"10","key":"2019111521005198400_B23","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1182\/blood-2002-03-0898","article-title":"Interaction of human hematopoietic stem cells with bacterial pathogens","volume":"100","author":"Kolb-M\u00e4urer","year":"2002","journal-title":"Blood"},{"key":"2019111521005198400_B24","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3389\/fimmu.2016.00364","article-title":"Impact of viral infections on hematopoiesis: from beneficial to detrimental effects on bone marrow output","volume":"7","author":"Pascutti","year":"2016","journal-title":"Front Immunol"},{"issue":"3","key":"2019111521005198400_B25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cell.2017.11.018","article-title":"Intrinsic immunity shapes viral resistance of stem cells","volume":"172","author":"Wu","year":"2018","journal-title":"Cell"},{"issue":"5","key":"2019111521005198400_B26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1089\/jir.1996.16.375","article-title":"Partial inhibition of vesicular stomatitis virus by the interferon-induced human 9-27 protein","volume":"16","author":"Alber","year":"1996","journal-title":"J Interferon Cytokine Res"},{"issue":"5","key":"2019111521005198400_B27","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1089\/hum.2015.156","article-title":"Human, pig, and mouse interferon-induced transmembrane proteins partially restrict pseudotyped lentiviral vectors","volume":"27","author":"Hornick","year":"2016","journal-title":"Hum Gene Ther"},{"issue":"1","key":"2019111521005198400_B28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12977-018-0409-2","article-title":"A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery","volume":"15","author":"Roesch","year":"2018","journal-title":"Retrovirology"},{"issue":"1","key":"2019111521005198400_B29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12977-017-0377-y","article-title":"More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteins","volume":"14","author":"Shi","year":"2017","journal-title":"Retrovirology"},{"issue":"1","key":"2019111521005198400_B30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1089\/jir.2010.0112","article-title":"The small interferon-induced transmembrane genes and proteins","volume":"31","author":"Siegrist","year":"2011","journal-title":"J Interferon Cytokine Res"},{"issue":"43","key":"2019111521005198400_B31","doi-asserted-by":"crossref","first-page":"E10069","DOI":"10.1073\/pnas.1811892115","article-title":"mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3","volume":"115","author":"Shi","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"2019111521005198400_B32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cmet.2014.01.001","article-title":"Rapamycin: one drug, many effects","volume":"19","author":"Li","year":"2014","journal-title":"Cell Metab"},{"key":"2019111521005198400_B33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.omtm.2018.04.001","article-title":"Staurosporine increases lentiviral vector transduction efficiency of human hematopoietic stem and progenitor cells","volume":"9","author":"Lewis","year":"2018","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"10","key":"2019111521005198400_B34","doi-asserted-by":"crossref","first-page":"e1000633","DOI":"10.1371\/journal.ppat.1000633","article-title":"The HIV envelope but not VSV glycoprotein is capable of mediating HIV latent infection of resting CD4 T cells","volume":"5","author":"Yu","year":"2009","journal-title":"PLoS Pathog"},{"issue":"13","key":"2019111521005198400_B35","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1002\/anie.201311299","article-title":"9-Membered carbocycle formation: development of distinct Friedel-Crafts cyclizations and application to a scalable total synthesis of (\u00b1)-caraphenol A","volume":"53","author":"Wright","year":"2014","journal-title":"Angew Chem Int Ed Engl"},{"issue":"20","key":"2019111521005198400_B36","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1038\/sj.gt.3302801","article-title":"T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery [published correction appears in Gene Ther. 2007;14(7):626]","volume":"13","author":"Swan","year":"2006","journal-title":"Gene Ther"},{"issue":"4","key":"2019111521005198400_B37","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nprot.2009.22","article-title":"Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors","volume":"4","author":"Kutner","year":"2009","journal-title":"Nat Protoc"},{"issue":"3A 3a","key":"2019111521005198400_B38","first-page":"2081","article-title":"Resveratrol oligomers are potent MRP1 transport inhibitors","volume":"26","author":"Bobrowska-H\u00e4gerstrand","year":"2006","journal-title":"Anticancer Res"},{"issue":"8","key":"2019111521005198400_B39","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1055\/s-2003-42787","article-title":"Anti-inflammatory effect of the oligomeric stilbene alpha-Viniferin and its mode of the action through inhibition of cyclooxygenase-2 and inducible nitric oxide synthase","volume":"69","author":"Chung","year":"2003","journal-title":"Planta Med"},{"issue":"4","key":"2019111521005198400_B40","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1254\/jphs.09247FP","article-title":"alpha-Viniferin suppresses the signal transducer and activation of transcription-1 (STAT-1)-inducible inflammatory genes in interferon-gamma-stimulated macrophages","volume":"112","author":"Chung","year":"2010","journal-title":"J Pharmacol Sci"},{"issue":"16","key":"2019111521005198400_B41","doi-asserted-by":"crossref","first-page":"8632","DOI":"10.1021\/jf201561e","article-title":"Resveratrol oligomers isolated from Carex species inhibit growth of human colon tumorigenic cells mediated by cell cycle arrest","volume":"59","author":"Gonz\u00e1lez-Sarr\u00edas","year":"2011","journal-title":"J Agric Food Chem"},{"issue":"12","key":"2019111521005198400_B42","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1248\/bpb.33.2024","article-title":"Stilbene derivatives as human 5-HT(6) receptor antagonists from the root of Caragana sinica","volume":"33","author":"Kim","year":"2010","journal-title":"Biol Pharm Bull"},{"issue":"10","key":"2019111521005198400_B43","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1055\/s-0031-1298623","article-title":"Polyphenolic acetylcholinesterase inhibitors from Hopea chinensis","volume":"78","author":"Yan","year":"2012","journal-title":"Planta Med"},{"issue":"3","key":"2019111521005198400_B44","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/anie.201000044","article-title":"Plant polyphenols: chemical properties, biological activities, and synthesis","volume":"50","author":"Quideau","year":"2011","journal-title":"Angew Chem Int Ed Engl"},{"issue":"17","key":"2019111521005198400_B45","doi-asserted-by":"crossref","first-page":"8976","DOI":"10.1021\/cr500689b","article-title":"Chemistry and biology of resveratrol-derived natural products","volume":"115","author":"Keylor","year":"2015","journal-title":"Chem Rev"},{"issue":"7352","key":"2019111521005198400_B46","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature10197","article-title":"Regioselective reactions for programmable resveratrol oligomer synthesis","volume":"474","author":"Snyder","year":"2011","journal-title":"Nature"},{"issue":"6317","key":"2019111521005198400_B47","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.aaj1597","article-title":"Synthesis of resveratrol tetramers via a stereoconvergent radical equilibrium","volume":"354","author":"Keylor","year":"2016","journal-title":"Science"},{"issue":"12","key":"2019111521005198400_B48","doi-asserted-by":"crossref","first-page":"E235","DOI":"10.1002\/ajh.23837","article-title":"Resveratrol increases the bone marrow hematopoietic stem and progenitor cell capacity","volume":"89","author":"Rimmel\u00e9","year":"2014","journal-title":"Am J Hematol"},{"issue":"9","key":"2019111521005198400_B49","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.5966\/sctm.2014-0284","article-title":"Comparison of different cytokine conditions reveals resveratrol as a new molecule for ex vivo cultivation of cord blood-derived hematopoietic stem cells","volume":"4","author":"Heinz","year":"2015","journal-title":"Stem Cells Transl Med"},{"issue":"17","key":"2019111521005198400_B50","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1089\/10430340152677430","article-title":"Differential transduction efficiency of SCID-repopulating cells derived from umbilical cord blood and granulocyte colony-stimulating factor-mobilized peripheral blood","volume":"12","author":"Pollok","year":"2001","journal-title":"Hum Gene Ther"},{"issue":"36","key":"2019111521005198400_B51","doi-asserted-by":"crossref","first-page":"36ra43","DOI":"10.1126\/scitranslmed.3000931","article-title":"RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma","volume":"2","author":"DiGiusto","year":"2010","journal-title":"Sci Transl Med"},{"issue":"7313","key":"2019111521005198400_B52","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nature09328","article-title":"Transfusion independence and HMGA2 activation after gene therapy of human \u03b2-thalassaemia","volume":"467","author":"Cavazzana-Calvo","year":"2010","journal-title":"Nature"},{"issue":"5954","key":"2019111521005198400_B53","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.1171242","article-title":"Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy","volume":"326","author":"Cartier","year":"2009","journal-title":"Science"},{"issue":"2","key":"2019111521005198400_B54","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/mt.2014.193","article-title":"Cyclosporin a and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells","volume":"23","author":"Petrillo","year":"2015","journal-title":"Mol Ther"},{"issue":"10","key":"2019111521005198400_B55","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.5966\/sctm.2014-0010","article-title":"Enhanced genetic modification of adult growth factor mobilized peripheral blood hematopoietic stem and progenitor cells with rapamycin","volume":"3","author":"Li","year":"2014","journal-title":"Stem Cells Transl Med"},{"issue":"9","key":"2019111521005198400_B56","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.bbmt.2009.05.015","article-title":"Lymphocyte recovery is a major determinant of outcome after matched unrelated myeloablative transplantation for myelogenous malignancies","volume":"15","author":"Le Blanc","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"issue":"335","key":"2019111521005198400_B57","doi-asserted-by":"crossref","first-page":"335ra57","DOI":"10.1126\/scitranslmed.aad8856","article-title":"Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency","volume":"8","author":"De Ravin","year":"2016","journal-title":"Sci Transl Med"},{"key":"2019111521005198400_B58","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41698-017-0038-6","article-title":"The therapeutic potential of resveratrol: a review of clinical trials","volume":"1","author":"Berman","year":"2017","journal-title":"NPJ Precis Oncol"},{"key":"2019111521005198400_B59","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/978-1-4939-1133-2_22","article-title":"High-throughput genomic mapping of vector integration sites in gene therapy studies","volume":"1185","author":"Beard","year":"2014","journal-title":"Methods Mol Biol"},{"issue":"1","key":"2019111521005198400_B60","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0168-1702(03)00117-5","article-title":"Wild-type measles virus induces large syncytium formation in primary human small airway epithelial cells by a SLAM(CD150)-independent mechanism","volume":"94","author":"Takeuchi","year":"2003","journal-title":"Virus Res"},{"issue":"7","key":"2019111521005198400_B61","doi-asserted-by":"crossref","first-page":"e02255","DOI":"10.1128\/JVI.02255-16","article-title":"The Measles virus receptor SLAMF1 can mediate particle endocytosis","volume":"91","author":"Gon\u00e7alves-Carneiro","year":"2017","journal-title":"J Virol"},{"issue":"7","key":"2019111521005198400_B62","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/ncb1269","article-title":"Endosome-to-cytosol transport of viral nucleocapsids","volume":"7","author":"Le Blanc","year":"2005","journal-title":"Nat Cell Biol"},{"issue":"11","key":"2019111521005198400_B63","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/nbt745","article-title":"A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes","volume":"20","author":"Cavrois","year":"2002","journal-title":"Nat Biotechnol"},{"issue":"3","key":"2019111521005198400_B64","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cell.2009.02.046","article-title":"HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes","volume":"137","author":"Miyauchi","year":"2009","journal-title":"Cell"},{"key":"2019111521005198400_B65","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-59745-170-3_5","article-title":"Real-time PCR analysis of HIV-1 replication post-entry events","volume":"485","author":"Mbisa","year":"2009","journal-title":"Methods Mol Biol"},{"issue":"1","key":"2019111521005198400_B66","doi-asserted-by":"crossref","first-page":"e1001258","DOI":"10.1371\/journal.ppat.1001258","article-title":"Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus","volume":"7","author":"Huang","year":"2011","journal-title":"PLoS Pathog"},{"issue":"10","key":"2019111521005198400_B67","doi-asserted-by":"crossref","first-page":"e1002337","DOI":"10.1371\/journal.ppat.1002337","article-title":"IFITM3 inhibits influenza A virus infection by preventing cytosolic entry","volume":"7","author":"Feeley","year":"2011","journal-title":"PLoS Pathog"},{"issue":"24","key":"2019111521005198400_B68","doi-asserted-by":"crossref","first-page":"12646","DOI":"10.1128\/JVI.01328-10","article-title":"Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms","volume":"84","author":"Weidner","year":"2010","journal-title":"J Virol"},{"issue":"11","key":"2019111521005198400_B69","doi-asserted-by":"crossref","first-page":"e00246","DOI":"10.1128\/JVI.00246-17","article-title":"pH optimum of hemagglutinin-mediated membrane fusion determines sensitivity of influenza A viruses to the interferon-induced antiviral state and IFITMs","volume":"91","author":"Gerlach","year":"2017","journal-title":"J Virol"},{"issue":"8","key":"2019111521005198400_B70","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/2211-5463.12246","article-title":"IFITM1 suppresses expression of human endogenous retroviruses in human embryonic stem cells","volume":"7","author":"Fu","year":"2017","journal-title":"FEBS Open Bio"},{"issue":"7555","key":"2019111521005198400_B71","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature14308","article-title":"Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells","volume":"522","author":"Grow","year":"2015","journal-title":"Nature"},{"issue":"24","key":"2019111521005198400_B72","doi-asserted-by":"crossref","first-page":"13697","DOI":"10.1128\/JVI.01828-12","article-title":"The N-terminal region of IFITM3 modulates its antiviral activity by regulating IFITM3 cellular localization","volume":"86","author":"Jia","year":"2012","journal-title":"J Virol"},{"issue":"5","key":"2019111521005198400_B73","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1128\/JVI.73.5.3649-3660.1999","article-title":"Transduction of human progenitor hematopoietic stem cells by human immunodeficiency virus type 1-based vectors is cell cycle dependent","volume":"73","author":"Sutton","year":"1999","journal-title":"J Virol"},{"issue":"1","key":"2019111521005198400_B74","doi-asserted-by":"crossref","first-page":"21772","DOI":"10.1038\/srep21772","article-title":"Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition","volume":"6","author":"Park","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"2019111521005198400_B75","doi-asserted-by":"crossref","first-page":"e9199","DOI":"10.1371\/journal.pone.0009199","article-title":"SIRT1 negatively regulates the mammalian target of rapamycin","volume":"5","author":"Ghosh","year":"2010","journal-title":"PLoS One"},{"issue":"3","key":"2019111521005198400_B76","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1158\/0008-5472.CAN-09-3537","article-title":"Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62\/SQSTM1 expression and AMPK activation","volume":"70","author":"Puissant","year":"2010","journal-title":"Cancer Res"},{"issue":"3","key":"2019111521005198400_B77","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41589-018-0213-2","article-title":"IFITM3 directly engages and shuttles incoming virus particles to lysosomes","volume":"15","author":"Spence","year":"2019","journal-title":"Nat Chem Biol"},{"issue":"6","key":"2019111521005198400_B78","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1177\/1753425912443392","article-title":"Interferon-inducible transmembrane proteins of the innate immune response act as membrane organizers by influencing clathrin and v-ATPase localization and function","volume":"18","author":"Wee","year":"2012","journal-title":"Innate Immun"},{"issue":"24","key":"2019111521005198400_B79","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.1016\/j.jmb.2013.09.024","article-title":"IFITMs restrict the replication of multiple pathogenic viruses","volume":"425","author":"Perreira","year":"2013","journal-title":"J Mol Biol"},{"issue":"7395","key":"2019111521005198400_B80","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature10921","article-title":"IFITM3 restricts the morbidity and mortality associated with influenza","volume":"484","author":"Everitt","year":"2012","journal-title":"Nature"},{"issue":"8","key":"2019111521005198400_B81","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm.4370","article-title":"SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans","volume":"23","author":"Allen","year":"2017","journal-title":"Nat Med"},{"issue":"4","key":"2019111521005198400_B82","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/1759-7714.12451","article-title":"Interferon induced transmembrane protein 3 regulates the growth and invasion of human lung adenocarcinoma","volume":"8","author":"Zhang","year":"2017","journal-title":"Thorac Cancer"},{"issue":"1","key":"2019111521005198400_B83","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3892\/or.2013.2428","article-title":"Knockdown of interferon-induced transmembrane protein 3 expression suppresses breast cancer cell growth and colony formation and affects the cell cycle","volume":"30","author":"Yang","year":"2013","journal-title":"Oncol Rep"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/134\/16\/1298\/1248560\/bloodbld2019000040.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/134\/16\/1298\/1248560\/bloodbld2019000040.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T16:07:20Z","timestamp":1610813240000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/134\/16\/1298\/374955\/Resveratrol-trimer-enhances-gene-delivery-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,15]]},"references-count":84,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2019,8,15]]},"published-print":{"date-parts":[[2019,10,17]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2019000040","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,15]]}}}