{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:19:04Z","timestamp":1792685944571,"version":"4.5.0"},"reference-count":42,"publisher":"American Society of Hematology","issue":"11","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,9,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The use of anti-thymocyte globulin (ATG) has represented the standard of care in graft-versus-host disease (GVHD) prophylaxis in patients undergoing a mismatched unrelated donor (MMUD) transplant. The safety and feasibility of posttransplant cyclophosphamide (PTCY) in this setting have been reported recently, but no study has compared the outcomes of PTCY vs ATG in 9\/10 MMUD transplants. Using the registry data of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we performed a matched-pair analysis comparing those 2 strategies in a 9\/10 MMUD setting. Ninety-three patients receiving PTCY were matched with 179 patients receiving ATG. A significantly lower incidence of severe acute GVHD was observed with PTCY compared with ATG. Recipients of the former also showed higher leukemia-free survival and GVHD\/relapse-free survival (GRFS). When performing a subgroup analysis including patients receiving peripheral blood stem cells, being in complete remission, or receiving the same associated immunosuppressive agents, superiority of PTCY over ATG was confirmed. Similar to the haploidentical setting, use of PTCY is an effective anti-GVHD prophylaxis in the 9\/10 MMUD transplant. Use of PTCY may also provide better outcomes in long-term disease control. These results need confirmation in large prospective randomized trials.<\/jats:p>","DOI":"10.1182\/blood.2019000487","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T22:25:19Z","timestamp":1562192719000},"page":"892-899","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":171,"title":["Posttransplant cyclophosphamide vs antithymocyte globulin in HLA-mismatched unrelated donor transplantation"],"prefix":"10.1182","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-1786","authenticated-orcid":false,"given":"Giorgia","family":"Battipaglia","sequence":"first","affiliation":[{"name":"Hematology Department, H\u00f4pital Saint Antoine, Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire, Paris, France;"},{"name":"Hematology Department, Federico II University, Naples, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"Hematology Department, H\u00f4pital Saint Antoine, Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire, Paris, France;"},{"name":"Acute Leukemia Working Party of EBMT, Paris, France;"},{"name":"Hospital Saint-Antoine, Paris University UPMC, INSERM U938, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaus","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Centre, University Hospital Eppendorf, Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonin","family":"Vitek","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Transfusion, Servicio de Hematolog\u00eda, Prague, Czech Republic;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Afanasyev","sequence":"additional","affiliation":[{"name":"First State Pavlov Medical University of St. Petersburg, Raisa Gorbacheva Memorial Research Institute for Paediatric Oncology, Hematology, and Transplantation, St. Petersburg, Russia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2038-9730","authenticated-orcid":false,"given":"Inken","family":"Hilgendorf","sequence":"additional","affiliation":[{"name":"Universitaetsklinikum Jena, Klinik f\u00fcr Innere Medizin II, Abt. H\u00e4matologie und Internistische Onkologie, Jena, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-2981","authenticated-orcid":false,"given":"Johannes","family":"Schetelig","sequence":"additional","affiliation":[{"name":"Universitaetsklinikum Dresden, Medizinische Klinik und Poliklinik I, Dresden, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Ganser","sequence":"additional","affiliation":[{"name":"Department of Haematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5684-9447","authenticated-orcid":false,"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Programme de Transplantation et Therapie Cellulaire, Centre de Recherche en Canc\u00e9rologie de Marseille Institut Paoli Calmettes, Marseille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5844-1632","authenticated-orcid":false,"given":"Maija","family":"It\u00e4l\u00e4-Remes","sequence":"additional","affiliation":[{"name":"Stem Cell Transplantation Unit, HUCH Comprehensive Cancer Center, Helsinki, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7092-3351","authenticated-orcid":false,"given":"Jakob R.","family":"Passweg","sequence":"additional","affiliation":[{"name":"University Hospital, Hematology, Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bonifazi","sequence":"additional","affiliation":[{"name":"Bologna University, S. Orsola-Malpighi Hospital, Institute of Hematology and Medical Oncology, L & A Ser\u00e0gnoli, Bologna, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Finke","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2013Hematology, Oncology, University of Freiburg, Freiburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, IRCCS Bambino Ges\u00f9 Children's Hospital, Rome, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon","family":"Nagler","sequence":"additional","affiliation":[{"name":"Acute Leukemia Working Party of EBMT, Paris, France;"},{"name":"Chaim Sheba Medical Center, Tel-Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Mohty","sequence":"additional","affiliation":[{"name":"Hematology Department, H\u00f4pital Saint Antoine, Service d'H\u00e9matologie et Th\u00e9rapie Cellulaire, Paris, France;"},{"name":"Acute Leukemia Working Party of EBMT, Paris, France;"},{"name":"Hospital Saint-Antoine, Paris University UPMC, INSERM U938, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"2","key":"2020021109181388300_B1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0198-8859(90)90071-V","article-title":"Effect of HLA incompatibility on graft-versus-host disease, relapse, and survival after marrow transplantation for patients with leukemia or lymphoma","volume":"29","author":"Anasetti","year":"1990","journal-title":"Hum Immunol"},{"issue":"10","key":"2020021109181388300_B2","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1182\/blood.V92.10.3515","article-title":"Optimizing outcome after unrelated marrow transplantation by comprehensive matching of HLA class I and II alleles in the donor and recipient","volume":"92","author":"Petersdorf","year":"1998","journal-title":"Blood"},{"issue":"9","key":"2020021109181388300_B3","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1182\/blood-2004-04-1674","article-title":"Limits of HLA mismatching in unrelated hematopoietic cell transplantation","volume":"104","author":"Petersdorf","year":"2004","journal-title":"Blood"},{"issue":"6","key":"2020021109181388300_B4","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.bbmt.2010.09.012","article-title":"HLA-C antigen mismatch is associated with worse outcome in unrelated donor peripheral blood stem cell transplantation","volume":"17","author":"Woolfrey","year":"2011","journal-title":"Biol Blood Marrow Transplant"},{"issue":"6","key":"2020021109181388300_B5","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3324\/haematol.2015.138180","article-title":"Expanding transplant options to patients over 50 years. 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