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The treatment has remained empirical, resulting in dismal outcomes. We, therefore, performed whole-exome and RNA sequencing of these rare hematologic malignancies and present the most complete survey of the genomic landscape of these diseases to date. We observed a diversity of combinatorial mutational patterns that generally do not cluster within any one diagnosis. Gene expression analysis reveals enrichment, but not cosegregation, of clinical and genetic disease features with transcriptional clusters. In conclusion, these groups of diseases represent a continuum of related diseases rather than discrete diagnostic entities.<\/jats:p>","DOI":"10.1182\/blood.2019000611","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T22:05:33Z","timestamp":1564610733000},"page":"867-879","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":82,"title":["Genomic landscape of neutrophilic leukemias of ambiguous diagnosis"],"prefix":"10.1182","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0749-9866","authenticated-orcid":false,"given":"Haijiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cell, Developmental and Cancer Biology,"},{"name":"Division of Hematology and Medical Oncology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Wilmot","sequence":"additional","affiliation":[{"name":"Division of Bioinformatics and Computational 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