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The multiplicity of genes identified in the 571 subjects reflects the complex requirements of B-cell antigen signaling, activation, survival, migration, maturation, and maintenance of antibody-secreting memory B-cell populations to the plasma cell stage. For the US and Swedish cohorts, CVID subjects with noninfectious complications, lymphoid infiltrations, inflamatory conditions, or autoimmunity were somewhat more likely to have an identifiable gene, but in both cohorts, numerous subjects with these medical conditions had no potential gene that could be assigned. Specific clinical patterns of illnesses were also not linked to any given gene defect as there was considerable overlap in clinical presentations. These observations led to a new perspective on the complexity of the immunologic phenotype found in CVID syndrome.<\/jats:p>","DOI":"10.1182\/blood.2019000929","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T20:09:40Z","timestamp":1579118980000},"page":"656-667","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":174,"title":["Current genetic landscape in common variable immune deficiency"],"prefix":"10.1182","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-0407","authenticated-orcid":false,"given":"Hassan","family":"Abolhassani","sequence":"first","affiliation":[{"name":"Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska Hospital Huddinge, Stockholm, Sweden;"},{"name":"Research Center for Immunodeficiencies, Pediatric Center of Excellence, Children\u2019s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Hammarstr\u00f6m","sequence":"first","affiliation":[{"name":"Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska Hospital Huddinge, Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cunningham-Rundles","sequence":"first","affiliation":[{"name":"Division of Clinical Immunology, Departments of Medicine and Pediatrics and"},{"name":"Graduate School of Biomedical Sciences, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"5","key":"2020022706594272700_B1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1542\/peds.47.5.927","article-title":"Primary immunodeficiencies. 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