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Chromatin immunoprecipitation sequencing analysis revealed that IRF4-bound regions were more frequently found in super-enhancers than in typical enhancers. NF-\u03baB was found to co-occupy IRF4-bound regulatory elements and formed a coherent feed-forward loop to coordinately regulate genes involved in T-cell functions and development. Importantly, IRF4 and NF-\u03baB regulated several cancer genes associated with super-enhancers in ATL cells, including MYC, CCR4, and BIRC3. Genetic inhibition of BIRC3 induced growth inhibition in ATL cells, implicating its role as a critical effector molecule downstream of the IRF4-NF-\u03baB transcriptional network.<\/jats:p>","DOI":"10.1182\/blood.2019002639","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T16:09:41Z","timestamp":1579795781000},"page":"934-947","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":44,"title":["Feed-forward regulatory loop driven by IRF4 and NF-\u03baB in adult T-cell leukemia\/lymphoma"],"prefix":"10.1182","volume":"135","author":[{"given":"Regina Wan Ju","family":"Wong","sequence":"first","affiliation":[{"name":"Cancer Science Institute of Singapore, National University of Singapore, Singapore;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze King","family":"Tan","sequence":"first","affiliation":[{"name":"Cancer Science Institute of Singapore, National University of 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cells","volume":"129","author":"Watanabe","year":"2017","journal-title":"Blood"},{"issue":"39","key":"2020031912001108400_B6","doi-asserted-by":"crossref","first-page":"5926","DOI":"10.1038\/sj.onc.1208980","article-title":"History of the discoveries of the first human retroviruses: HTLV-1 and HTLV-2","volume":"24","author":"Gallo","year":"2005","journal-title":"Oncogene"},{"issue":"3","key":"2020031912001108400_B7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1349-7006.1989.tb02289.x","article-title":"Multi-step carcinogenesis model for adult T-cell leukemia","volume":"80","author":"Okamoto","year":"1989","journal-title":"Jpn J Cancer Res"},{"issue":"2","key":"2020031912001108400_B8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cell.2013.03.035","article-title":"Master transcription factors and mediator establish super-enhancers at key cell identity 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Malignancy! 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lymphomas","volume":"23","author":"Feldman","year":"2009","journal-title":"Leukemia"},{"issue":"3","key":"2020031912001108400_B52","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/sj.leu.2401696","article-title":"MUM1\/IRF4 expression as a frequent event in mature lymphoid malignancies","volume":"14","author":"Tsuboi","year":"2000","journal-title":"Leukemia"},{"issue":"2","key":"2020031912001108400_B53","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.immuni.2006.07.009","article-title":"Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation","volume":"25","author":"Sciammas","year":"2006","journal-title":"Immunity"},{"issue":"18","key":"2020031912001108400_B54","doi-asserted-by":"crossref","first-page":"6844","DOI":"10.1074\/jbc.RA117.000164","article-title":"An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell 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