{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:32:27Z","timestamp":1793226747335,"version":"4.5.0"},"reference-count":25,"publisher":"American Society of Hematology","issue":"15","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,4,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Antiplatelet therapies have been proposed for the treatment of sepsis, a syndrome resulting from a dysregulated immune response and inappropriate activation of coagulation. Acetylsalicylic acid (ASA) may serve as a potential therapeutic strategy to prevent infection-induced coagulopathy and associated tissue damage. Using intravital microscopy, we found that Staphylococcus aureus infection induced neutrophil recruitment, platelet aggregation, and neutrophil extracellular trap (NET) release in the liver. Mice pretreated with ASA, or animals receiving ASA 3 hours postinfection, had significantly reduced platelet aggregation and NET release. Additionally, ASA-treated mice had reduced intravascular thrombin activity and microvascular occlusion as compared with untreated S aureus\u2013infected mice. This inhibition of coagulation was accompanied by decreased levels of alanine aminotransferase and aspartate aminotransferase in the plasma, indicating less liver damage. Finally, bacterial loads (colony-forming units per milliliter) in liver, lung, and spleen were not different between groups, and the phagocytic capacity of Kupffer cells was preserved following ASA treatment. These results suggest that ASA may serve as a therapeutic approach to sepsis through its ability to reduce the deleterious action of immunothrombi while maintaining innate immune functions.<\/jats:p>","DOI":"10.1182\/blood.2019002783","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T19:59:33Z","timestamp":1579291173000},"page":"1281-1286","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":54,"title":["Acetylsalicylic acid inhibits intravascular coagulation during Staphylococcus aureus\u2013induced sepsis in mice"],"prefix":"10.1182","volume":"135","author":[{"given":"Agostina","family":"Carestia","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Infectious Diseases, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachelle P.","family":"Davis","sequence":"first","affiliation":[{"name":"Department 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