{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:30:04Z","timestamp":1792798204850,"version":"4.5.0"},"reference-count":43,"publisher":"American Society of Hematology","issue":"15","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,4,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Human graft-versus-host disease (GVHD) biology beyond 3 months after hematopoietic stem cell transplantation (HSCT) is complex. The Applied Biomarker in Late Effects of Childhood Cancer study (ABLE\/PBMTC1202, NCT02067832) evaluated the immune profiles in chronic GVHD (cGVHD) and late acute GVHD (L-aGVHD). Peripheral blood immune cell and plasma markers were analyzed at day 100 post-HSCT and correlated with GVHD diagnosed according to the National Institutes of Health consensus criteria (NIH-CC) for cGVHD. Of 302 children enrolled, 241 were evaluable as L-aGVHD, cGVHD, active L-aGVHD or cGVHD, and no cGVHD\/L-aGVHD. Significant marker differences, adjusted for major clinical factors, were defined as meeting all 3 criteria: receiver-operating characteristic area under the curve \u22650.60, P \u2264 .05, and effect ratio \u22651.3 or \u22640.75. Patients with only distinctive features but determined as cGVHD by the adjudication committee (non-NIH-CC) had immune profiles similar to NIH-CC. Both cGVHD and L-aGVHD had decreased transitional B cells and increased cytolytic natural killer (NK) cells. cGVHD had additional abnormalities, with increased activated T cells, naive helper T (Th) and cytotoxic T cells, loss of CD56bright regulatory NK cells, and increased ST2 and soluble CD13. Active L-aGVHD before day 114 had additional abnormalities in naive Th, naive regulatory T (Treg) cell populations, and cytokines, and active cGVHD had an increase in PD-1\u2212 and a decrease in PD-1+ memory Treg cells. Unsupervised analysis appeared to show a progression of immune abnormalities from no cGVHD\/L-aGVHD to L-aGVHD, with the most complex pattern in cGVHD. Comprehensive immune profiling will allow us to better understand how to minimize L-aGVHD and cGVHD. Further confirmation in adult and pediatric cohorts is needed.<\/jats:p>","DOI":"10.1182\/blood.2019003186","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T01:06:22Z","timestamp":1581469582000},"page":"1287-1298","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":66,"title":["Immune profile differences between chronic GVHD and late acute GVHD: results of the ABLE\/PBMTC 1202 studies"],"prefix":"10.1182","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0001-6438","authenticated-orcid":false,"given":"Kirk R.","family":"Schultz","sequence":"first","affiliation":[{"name":"Michael Cuccione Childhood Cancer research program, British Columbia Children\u2019s Hospital, University of British Columbia, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Kariminia","sequence":"first","affiliation":[{"name":"Michael Cuccione Childhood Cancer research program, British Columbia Children\u2019s Hospital, University of British Columbia, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Statistics, Centre for Molecular Medicine and Therapeutics, British Columbia Children\u2019s Hospital, University of British Columbia, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayeh","family":"Abdossamadi","sequence":"first","affiliation":[{"name":"Michael Cuccione Childhood Cancer research program, British Columbia Children\u2019s Hospital, University of British Columbia, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Lauener","sequence":"first","affiliation":[{"name":"Michael Cuccione Childhood Cancer research program, British Columbia Children\u2019s Hospital, University of British Columbia, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eneida R.","family":"Nemecek","sequence":"first","affiliation":[{"name":"Pediatric Blood and Marrow Transplantation, Doernbecher Children\u2019s Hospital, Oregon Health and Science University, Portland, OR;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin T.","family":"Wahlstrom","sequence":"first","affiliation":[{"name":"Blood and Marrow Transplantation Program, Benioff Children\u2019s Hospital, University of California San Francisco, San Francisco, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie L.","family":"Kitko","sequence":"first","affiliation":[{"name":"Pediatric Stem Cell Transplantation Program, Vanderbilt University Medical Center, Nashville, TN;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor A.","family":"Lewis","sequence":"first","affiliation":[{"name":"Pediatric Oncology, Alberta Children\u2019s Hospital, University of Calgary, Calgary, AB, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Schechter","sequence":"first","affiliation":[{"name":"Hematology-Oncology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Jacobsohn","sequence":"first","affiliation":[{"name":"Blood and Marrow Transplantation, Children\u2019s National Health System, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4538-8817","authenticated-orcid":false,"given":"Andrew C.","family":"Harris","sequence":"first","affiliation":[{"name":"Pediatric Hematology Oncology, Primary Children\u2019s Hospital, University of Utah, Salt Lake City, UT;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3030-8420","authenticated-orcid":false,"given":"Michael A.","family":"Pulsipher","sequence":"first","affiliation":[{"name":"Blood and Marrow Transplantation, Children\u2019s Hospital Los Angeles, Los Angeles, CA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Bittencourt","sequence":"first","affiliation":[{"name":"Hematology Oncology, Sainte-Justine University Hospital Center, Montreal, QC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6321-3834","authenticated-orcid":false,"given":"Sung Won","family":"Choi","sequence":"first","affiliation":[{"name":"Michigan Medicine Pediatric Bone Marrow Transplant, C.S. 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