{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T05:22:57Z","timestamp":1792905777370,"version":"4.5.0"},"reference-count":83,"publisher":"American Society of Hematology","issue":"12","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,9,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vitamin C serves as a cofactor for Fe(II) and 2-oxoglutarate\u2013dependent dioxygenases including TET family enzymes, which catalyze the oxidation of 5-methylcytosine into 5-hydroxymethylcytosine and further oxidize methylcytosines. Loss-of-function mutations in epigenetic regulators such as TET genes are prevalent in hematopoietic malignancies. Vitamin C deficiency is frequently observed in cancer patients. In this review, we discuss the role of vitamin C and TET proteins in cancer, with a focus on hematopoietic malignancies, T regulatory cells, and other immune system cells.<\/jats:p>","DOI":"10.1182\/blood.2019004158","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T01:26:57Z","timestamp":1596158817000},"page":"1394-1401","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":79,"title":["TET family dioxygenases and the TET activator vitamin C in immune responses and cancer"],"prefix":"10.1182","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3385-3857","authenticated-orcid":false,"given":"Xiaojing","family":"Yue","sequence":"first","affiliation":[{"name":"Division of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 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