{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:37:23Z","timestamp":1791686243137,"version":"4.3.4"},"reference-count":50,"publisher":"American Society of Hematology","issue":"19","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Patients with isolated pulmonary embolism (PE) have a distinct clinical profile from those with deep vein thrombosis (DVT)-associated PE, with more pulmonary conditions and atherosclerosis. These findings suggest a distinct molecular pathophysiology and the potential involvement of alternative pathways in isolated PE. To test this hypothesis, data from 532 individuals from the Genotyping and Molecular Phenotyping of Venous ThromboEmbolism Project, a multicenter prospective cohort study with extensive biobanking, were analyzed. Targeted, high-throughput proteomics, machine learning, and bioinformatic methods were applied to contrast the acute-phase plasma proteomes of isolated PE patients (n = 96) against those of patients with DVT-associated PE (n = 276) or isolated DVT (n = 160). This resulted in the identification of shared molecular processes between PE phenotypes, as well as an isolated PE-specific protein signature. Shared processes included upregulation of inflammation, response to oxidative stress, and the loss of pulmonary surfactant. The isolated PE-specific signature consisted of 5 proteins: interferon-\u03b3, glial cell line\u2013derived neurotrophic growth factor, polypeptide N-acetylgalactosaminyltransferase 3, peptidyl arginine deiminase type-2, and interleukin-15 receptor subunit \u03b1. These proteins were orthogonally validated using cis protein quantitative trait loci. External replication in an independent population-based cohort (n = 5778) further validated the proteomic results and showed that they were prognostic for incident primary isolated PE in individuals without history of VTE (median time to event: 2.9 years; interquartile range: 1.6-4.2 years), supporting their possible involvement in the early pathogenesis. This study has identified molecular overlaps and differences between VTE phenotypes. In particular, the results implicate noncanonical pathways more commonly associated with respiratory and atherosclerotic disease in the acute pathophysiology of isolated PE.<\/jats:p>","DOI":"10.1182\/blood.2019004571","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T12:11:45Z","timestamp":1612527105000},"page":"2681-2693","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":31,"title":["Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism"],"prefix":"10.1182","volume":"137","author":[{"given":"Vincent","family":"Ten Cate","sequence":"first","affiliation":[{"name":"Preventive Cardiology and Preventive Medicine, Center for Cardiology,"},{"name":"Center for Thrombosis and Hemostasis (CTH), and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen H.","family":"Prochaska","sequence":"additional","affiliation":[{"name":"Preventive Cardiology and Preventive Medicine, Center for Cardiology,"},{"name":"Center for Thrombosis and Hemostasis (CTH), and"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schulz","sequence":"additional","affiliation":[{"name":"Preventive Cardiology and Preventive Medicine, Center for Cardiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Koeck","sequence":"additional","affiliation":[{"name":"Preventive Cardiology and Preventive Medicine, Center for Cardiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Pallares Robles","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lenz","sequence":"additional","affiliation":[{"name":"Preventive Cardiology and Preventive Medicine, Center for Cardiology,"},{"name":"Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, Mainz, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Eggebrecht","sequence":"additional","affiliation":[{"name":"Preventive Cardiology and Preventive Medicine, Center for Cardiology,"},{"name":"Center for Thrombosis and Hemostasis (CTH), and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Rapp","sequence":"additional","affiliation":[{"name":"Preventive Cardiology and Preventive Medicine, Center for Cardiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Panova-Noeva","sequence":"additional","affiliation":[{"name":"Preventive Cardiology and Preventive Medicine, Center for Cardiology,"},{"name":"Center for Thrombosis and Hemostasis (CTH), and"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2029-4419","authenticated-orcid":false,"given":"H. Ardeschir","family":"Ghofrani","sequence":"additional","affiliation":[{"name":"University Hospital Gie\u00dfen and Marburg, Ambulance for Pulmonary Hypertension, Gie\u00dfen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Joachim","family":"Meyer","sequence":"additional","affiliation":[{"name":"Lung Center Munich, Department of Pneumology and Pneumological Oncology, M\u00fcnchen Klinik Bogenhausen, M\u00fcnchen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Espinola-Klein","sequence":"additional","affiliation":[{"name":"Department of Angiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl J.","family":"Lackner","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Michal","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K.","family":"Schuster","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Strauch","sequence":"additional","affiliation":[{"name":"Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Zink","sequence":"additional","affiliation":[{"name":"Bayer AG, Wuppertal, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-3683","authenticated-orcid":false,"given":"Volker","family":"Laux","sequence":"additional","affiliation":[{"name":"Bayer AG, Wuppertal, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Heitmeier","sequence":"additional","affiliation":[{"name":"Bayer AG, Wuppertal, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros V.","family":"Konstantinides","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), and"},{"name":"Department of Cardiology, Democritus University of Thrace, University General Hospital, Greece; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"M\u00fcnzel","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemostasis (CTH), and"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany;"},{"name":"Center for Cardiology \u2013 Cardiology I, University Medical Center of the Johannes Gutenberg University, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6650-1711","authenticated-orcid":false,"given":"Miguel A.","family":"Andrade-Navarro","sequence":"additional","affiliation":[{"name":"Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, Mainz, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Leineweber","sequence":"additional","affiliation":[{"name":"Bayer AG, Wuppertal, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp S.","family":"Wild","sequence":"additional","affiliation":[{"name":"Preventive Cardiology and Preventive Medicine, Center for Cardiology,"},{"name":"Center for Thrombosis and Hemostasis (CTH), and"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"5","key":"2021051315252271000_B1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.clinimag.2008.01.028","article-title":"64-Multidetector-row spiral CT in pulmonary embolism with emphasis on incidental findings","volume":"32","author":"Sohns","year":"2008","journal-title":"Clin Imaging"},{"issue":"2","key":"2021051315252271000_B2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3324\/haematol.2012.069195","article-title":"Finding the origin of pulmonary emboli with a total-body magnetic resonance direct thrombus imaging technique","volume":"98","author":"van Langevelde","year":"2013","journal-title":"Haematologica"},{"issue":"suppl 1","key":"2021051315252271000_B3","doi-asserted-by":"crossref","first-page":"10S","DOI":"10.1378\/chest.107.1_Supplement.10S","article-title":"Pathology of pulmonary thromboembolism","volume":"107","author":"Wagenvoort","year":"1995","journal-title":"Chest"},{"issue":"3","key":"2021051315252271000_B4","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1183\/09031936.00043313","article-title":"Asthma increases pulmonary thromboembolism risk: a nationwide population cohort study","volume":"43","author":"Chung","year":"2014","journal-title":"Eur Respir J"},{"issue":"3","key":"2021051315252271000_B5","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1378\/chest.08-1516","article-title":"Prevalence of pulmonary embolism in acute exacerbations of COPD: a systematic review and metaanalysis","volume":"135","author":"Rizkallah","year":"2009","journal-title":"Chest"},{"issue":"17","key":"2021051315252271000_B6","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.7150\/jca.26008","article-title":"Lung cancer and pulmonary embolism: what is the relationship? A review","volume":"9","author":"Li","year":"2018","journal-title":"J Cancer"},{"issue":"5","key":"2021051315252271000_B7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.5761\/atcs.ra.15-00157","article-title":"Postoperative acute pulmonary embolism following pulmonary resections","volume":"21","author":"Shonyela","year":"2015","journal-title":"Ann Thor Cardiovasc Surg"},{"issue":"2","key":"2021051315252271000_B8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.thromres.2014.05.011","article-title":"Short-term exposure to high levels of air pollution as a risk factor for acute isolated pulmonary embolism","volume":"134","author":"Spiezia","year":"2014","journal-title":"Thromb Res"},{"issue":"6","key":"2021051315252271000_B9","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.2214\/AJR.09.3599","article-title":"Chest radiographic and CT findings in novel swine-origin influenza A (H1N1) virus (S-OIV) infection","volume":"193","author":"Agarwal","year":"2009","journal-title":"AJR Am J Roentgenol"},{"issue":"8","key":"2021051315252271000_B10","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/MBC.0000000000000343","article-title":"Clinical characteristics of in-situ pulmonary artery thrombosis in Korea","volume":"26","author":"Cha","year":"2015","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"4","key":"2021051315252271000_B11","doi-asserted-by":"crossref","first-page":"ofw214","DOI":"10.1093\/ofid\/ofw214","article-title":"H1N1-induced venous thromboembolic events? Results of a single-institution case series","volume":"3","author":"Dimakakos","year":"2016","journal-title":"Open Forum Infect Dis"},{"issue":"5","key":"2021051315252271000_B12","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ejim.2009.06.001","article-title":"Prevalence of heart diseases in patients with pulmonary embolism with and without peripheral venous thrombosis: findings from a cross-sectional survey","volume":"20","author":"Prandoni","year":"2009","journal-title":"Eur J Intern Med"},{"issue":"13","key":"2021051315252271000_B13","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1161\/CIRCULATIONAHA.111.025627","article-title":"Heart disease may be a risk factor for pulmonary embolism without peripheral deep venous thrombosis","volume":"124","author":"S\u00f8rensen","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"2021051315252271000_B14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.chest.2020.01.055","article-title":"Isolated pulmonary embolism is associated with a high risk of arterial thrombotic disease: results from the VTEval Study","volume":"158","author":"Ten Cate","year":"2020","journal-title":"Chest"},{"key":"2021051315252271000_B15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.thromres.2019.07.019","article-title":"A prospective cohort study to identify and evaluate endotypes of venous thromboembolism: rationale and design of the Genotyping and Molecular Phenotyping in Venous ThromboEmbolism project (GMP-VTE)","volume":"181","author":"Ten Cate","year":"2019","journal-title":"Thromb Res"},{"issue":"4","key":"2021051315252271000_B16","doi-asserted-by":"crossref","first-page":"e95192","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability","volume":"9","author":"Assarsson","year":"2014","journal-title":"PLoS One"},{"key":"2021051315252271000_B17","article-title":"Rationale, design and baseline characteristics of the MyoVasc study: A prospective cohort study investigating development and progression of heart failure [published online ahead of print 14 May 2020]","author":"G\u00f6bel","journal-title":"Eur J Prev Cardiol"},{"issue":"7708","key":"2021051315252271000_B18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","article-title":"Genomic atlas of the human plasma proteome","volume":"558","author":"Sun","year":"2018","journal-title":"Nature"},{"issue":"6-7","key":"2021051315252271000_B19","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1007\/s00103-012-1502-7","article-title":"The Gutenberg Health Study [in German]","volume":"55","author":"Wild","year":"2012","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"issue":"D1","key":"2021051315252271000_B20","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"2021051315252271000_B21","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1093\/nar\/30.7.1575","article-title":"An efficient algorithm for large-scale detection of protein families","volume":"30","author":"Enright","year":"2002","journal-title":"Nucleic Acids Res"},{"issue":"suppl 11","key":"2021051315252271000_B22","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1182\/blood.V110.11.3977.3977","article-title":"Risk factors for isolated pulmonary embolism are opposite to those for DVT-associated PE: results of the 7532 patients prospective OPTIMEV Cohort Study [abstract]","volume":"110","author":"Bosson","year":"2007","journal-title":"Blood"},{"issue":"9225","key":"2021051315252271000_B23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0140-6736(00)02476-4","article-title":"Factor V Leiden paradox: risk of deep-vein thrombosis but not of pulmonary embolism","volume":"356","author":"Bounameaux","year":"2000","journal-title":"Lancet"},{"issue":"5","key":"2021051315252271000_B24","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1378\/chest.118.5.1405","article-title":"Inherited thrombophilic risk factors and venous thromboembolism: distinct role in peripheral deep venous thrombosis and pulmonary embolism","volume":"118","author":"Margaglione","year":"2000","journal-title":"Chest"},{"issue":"4","key":"2021051315252271000_B25","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.immuni.2009.09.002","article-title":"Cross-regulation of signaling pathways by interferon-\u03b3: implications for immune responses and autoimmune diseases","volume":"31","author":"Hu","year":"2009","journal-title":"Immunity"},{"issue":"4","key":"2021051315252271000_B26","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s12079-018-0486-y","article-title":"Comprehensive network map of interferon gamma signaling","volume":"12","author":"Bhat","year":"2018","journal-title":"J Cell Commun Signal"},{"issue":"7","key":"2021051315252271000_B27","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.4049\/jimmunol.181.7.5089","article-title":"Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-\u03b3 via superinduction of ATF-3 and suppression of AP-1","volume":"181","author":"Ho","year":"2008","journal-title":"J Immunol"},{"issue":"Pt 19","key":"2021051315252271000_B28","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1242\/jcs.00786","article-title":"Novel functions and signalling pathways for GDNF","volume":"116","author":"Sariola","year":"2003","journal-title":"J Cell Sci"},{"issue":"5","key":"2021051315252271000_B29","doi-asserted-by":"crossref","first-page":"L790","DOI":"10.1152\/ajplung.00449.2010","article-title":"Neurotrophin and GDNF family ligand receptor expression in vagal sensory nerve subtypes innervating the adult guinea pig respiratory tract","volume":"300","author":"Lieu","year":"2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"4","key":"2021051315252271000_B30","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1513\/pats.200504-033SR","article-title":"The role of vagal afferent nerves in chronic obstructive pulmonary disease","volume":"2","author":"Undem","year":"2005","journal-title":"Proc Am Thorac Soc"},{"issue":"4","key":"2021051315252271000_B31","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/j.bbrc.2018.08.058","article-title":"GALNT3 inhibits NF-\u03baB signaling during influenza A virus infection","volume":"503","author":"Wang","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"2021051315252271000_B32","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1128\/JVI.02246-15","article-title":"Influenza A virus-induced expression of a GalNAc transferase, GALNT3, via MicroRNAs is required for enhanced viral replication","volume":"90","author":"Nakamura","year":"2015","journal-title":"J Virol"},{"key":"2021051315252271000_B33","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3389\/fimmu.2012.00360","article-title":"Activation of PAD4 in NET formation","volume":"3","author":"Rohrbach","year":"2012","journal-title":"Front Immunol"},{"issue":"1","key":"2021051315252271000_B34","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s12931-017-0692-9","article-title":"Upregulation of citrullination pathway: from autoimmune to idiopathic lung fibrosis","volume":"18","author":"Samara","year":"2017","journal-title":"Respir Res"},{"key":"2021051315252271000_B35","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.3389\/fimmu.2018.02696","article-title":"Autoantibodies to Peptidylarginine Deiminase 2 Are Associated With Less Severe Disease in Rheumatoid Arthritis","volume":"9","author":"Darrah","year":"2018","journal-title":"Front Immunol"},{"issue":"1","key":"2021051315252271000_B36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13075-015-0520-x","article-title":"Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis","volume":"17","author":"Lugli","year":"2015","journal-title":"Arthritis Res Ther"},{"issue":"31","key":"2021051315252271000_B37","doi-asserted-by":"crossref","first-page":"49008","DOI":"10.18632\/oncotarget.10264","article-title":"Identification of IFN-\u03b3-producing T cells as the main mediators of the side effects associated to mouse interleukin-15 sustained exposure","volume":"7","author":"Di Scala","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"2021051315252271000_B38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.1365-2567.1999.00679.x","article-title":"Interleukin-15 differentially enhances the expression of interferon-\u03b3 and interleukin-4 in activated human (CD4+) T lymphocytes","volume":"96","author":"Borger","year":"1999","journal-title":"Immunology"},{"issue":"1","key":"2021051315252271000_B39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1398-9995.2008.01829.x","article-title":"Expression of osteopontin in chronic rhinosinusitis with and without nasal polyps","volume":"64","author":"Lu","year":"2009","journal-title":"Allergy"},{"key":"2021051315252271000_B40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.matbio.2018.03.017","article-title":"The WNT signaling pathways in wound healing and fibrosis","volume":"68-69","author":"Burgy","year":"2018","journal-title":"Matrix Biol"},{"issue":"3","key":"2021051315252271000_B41","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cytogfr.2006.01.001","article-title":"Roles of activin in tissue repair, fibrosis, and inflammatory disease","volume":"17","author":"Werner","year":"2006","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"2021051315252271000_B42","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"2021051315252271000_B43","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/ijlh.12084","article-title":"Platelets: bridging hemostasis, inflammation, and immunity","volume":"35","author":"Jenne","year":"2013","journal-title":"Int J Lab Hematol"},{"issue":"6","key":"2021051315252271000_B44","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1182\/blood-2016-05-718114","article-title":"The role of leukocytes in thrombosis","volume":"128","author":"Swystun","year":"2016","journal-title":"Blood"},{"key":"2021051315252271000_B45","doi-asserted-by":"crossref","first-page":"e07847","DOI":"10.7554\/eLife.07847","article-title":"Immune surveillance of the lung by migrating tissue monocytes","volume":"4","author":"Rodero","year":"2015","journal-title":"eLife"},{"issue":"2","key":"2021051315252271000_B46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1549-8719.2001.tb00159.x","article-title":"Mechanisms of leukocyte sequestration in inflamed lungs","volume":"8","author":"Doerschuk","year":"2001","journal-title":"Microcirculation"},{"issue":"6","key":"2021051315252271000_B47","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cytogfr.2015.04.003","article-title":"Cytokines in atherosclerosis: key players in all stages of disease and promising therapeutic targets","volume":"26","author":"Ramji","year":"2015","journal-title":"Cytokine Growth Factor Rev"},{"issue":"6","key":"2021051315252271000_B48","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1161\/CIRCRESAHA.114.303312","article-title":"Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis","volume":"114","author":"Knight","year":"2014","journal-title":"Circ Res"},{"issue":"4","key":"2021051315252271000_B49","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cardiores.2003.11.038","article-title":"Nuclear factor kappaB: a potential therapeutic target in atherosclerosis and thrombosis","volume":"61","author":"Monaco","year":"2004","journal-title":"Cardiovasc Res"},{"key":"2021051315252271000_B50","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejphar.2017.09.007","article-title":"Metalloproteinases in atherosclerosis","volume":"816","author":"Johnson","year":"2017","journal-title":"Eur J Pharmacol"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/137\/19\/2681\/1807142\/bloodbld2019004571.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/137\/19\/2681\/1807142\/bloodbld2019004571.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T15:27:55Z","timestamp":1620919675000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/137\/19\/2681\/475138\/Protein-expression-profiling-suggests-relevance-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,13]]},"references-count":50,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2021,5,13]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2019004571","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,13]]}}}