{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:45:13Z","timestamp":1792853113608,"version":"4.5.0"},"reference-count":48,"publisher":"American Society of Hematology","issue":"12","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,9,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasmodium falciparum gametocytes, the sexual stage responsible for malaria parasite transmission from humans to mosquitoes, are key targets for malaria elimination. Immature gametocytes develop in the human bone marrow parenchyma, where they accumulate around erythroblastic islands. Notably though, the interactions between gametocytes and this hematopoietic niche have not been investigated. Here, we identify late erythroblasts as a new host cell for P falciparum sexual stages and show that gametocytes can fully develop inside these nucleated cells in vitro and in vivo, leading to infectious mature gametocytes within reticulocytes. Strikingly, we found that infection of erythroblasts by gametocytes and parasite-derived extracellular vesicles delay erythroid differentiation, thereby allowing gametocyte maturation to coincide with the release of their host cell from the bone marrow. Taken together, our findings highlight new mechanisms that are pivotal for the maintenance of immature gametocytes in the bone marrow and provide further insights on how Plasmodium parasites interfere with erythropoiesis and contribute to anemia in malaria patients.<\/jats:p>","DOI":"10.1182\/blood.2019004746","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T07:36:42Z","timestamp":1593243402000},"page":"1381-1393","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":65,"title":["Plasmodium falciparum sexual parasites develop in human erythroblasts and affect erythropoiesis"],"prefix":"10.1182","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6970-3965","authenticated-orcid":false,"given":"Ga\u00eblle","family":"Neveu","sequence":"first","affiliation":[{"name":"INSERM U1016, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR) 8104, Universit\u00e9 de Paris, Institut Cochin, Paris, France;"},{"name":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrielle","family":"Richard","sequence":"additional","affiliation":[{"name":"INSERM U1016, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR) 8104, Universit\u00e9 de Paris, Institut Cochin, Paris, France;"},{"name":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Dupuy","sequence":"additional","affiliation":[{"name":"INSERM U1016, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR) 8104, Universit\u00e9 de Paris, Institut Cochin, Paris, France;"},{"name":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prativa","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ispat General Hospital, Rourkela, Odisha, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Volpe","sequence":"additional","affiliation":[{"name":"INSERM U1016, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR) 8104, Universit\u00e9 de Paris, Institut Cochin, Paris, France;"},{"name":"Laboratoire d\u2019Excellence GR-Ex, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep Annamalai","family":"Subramani","sequence":"additional","affiliation":[{"name":"INSERM U1135, CNRS Equipe de Recherche Labellis\u00e9e (ERL) 8255, Sorbonne Universit\u00e9, Centre d'Immunologie et des Maladies Infectieuses, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Marcel-Zerrougui","sequence":"additional","affiliation":[{"name":"Laboratoire Mati\u00e8res et Syst\u00e8mes Complexes, UMR 7057 CNRS, Universit\u00e9 de Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4758-6750","authenticated-orcid":false,"given":"Patrice","family":"Vallin","sequence":"additional","affiliation":[{"name":"INSERM U1016, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR) 8104, Universit\u00e9 de Paris, Institut Cochin, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Andrieu","sequence":"additional","affiliation":[{"name":"INSERM U1016, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR) 8104, Universit\u00e9 de Paris, Institut Cochin, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna Mukti","family":"Minz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ispat General Hospital, Rourkela, Odisha, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabih","family":"Azar","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9mobiologie, H\u00f4pital La Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7449-0696","authenticated-orcid":false,"given":"Rafael M.","family":"Martins","sequence":"additional","affiliation":[{"name":"Laboratory of Pathogen Host Interactions - UMR 5235, CNRS, INSERM, Universit\u00e9 de Montpellier, Montpellier, France; 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