{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:30:00Z","timestamp":1793179800642,"version":"4.5.0"},"reference-count":97,"publisher":"American Society of Hematology","issue":"6","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immune thrombocytopenia (ITP) is the most common acquired thrombocytopenia in children and is caused by immune-mediated decreased platelet production and increased platelet destruction. In the absence of a diagnostic test, ITP must be differentiated from other\u00a0thrombocytopenic disorders, including inherited platelet\u00a0disorders. In addition, a diagnosis of secondary ITP due to a primary immune deficiency with immune dysregulation may not be apparent at diagnosis but can alter management and should be considered in an expanding number of clinical scenarios. The diagnostic evaluation of\u00a0children with thrombocytopenia will vary based on the clinical history and laboratory features. Access to genotyping has broadened the ability to specify the etiology of thrombocytopenia, whereas increasing access\u00a0to immunophenotyping, functional immunologic and platelet assays, and biochemical markers has allowed for more in-depth evaluation of patients. With this greater availability of testing, diagnostic algorithms in patients with thrombocytopenia have become complex. In this article, we highlight the diagnostic evaluation of thrombocytopenia in children with a focus on ITP,\u00a0including consideration of underlying genetic and immune disorders, and use hypothetical patient cases to describe disease manifestations and strategies for treatment of pediatric ITP.<\/jats:p>","DOI":"10.1182\/blood.2020006480","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T17:58:35Z","timestamp":1630691915000},"page":"542-555","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":56,"title":["An update on pediatric ITP: differentiating primary ITP, IPD, and PID"],"prefix":"10.1182","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7302-0449","authenticated-orcid":false,"given":"Rachael F.","family":"Grace","sequence":"first","affiliation":[{"name":"1Dana-Farber\/Boston Children\u2019s Cancer and Blood Disorders Center, Boston, MA;"},{"name":"2Harvard Medical School, Boston, MA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0439-402X","authenticated-orcid":false,"given":"Michele P.","family":"Lambert","sequence":"additional","affiliation":[{"name":"3Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA; and"},{"name":"4Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"11","key":"2022081115222672400_B1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1542\/pir.26.11.401","article-title":"Thrombocytopenia during childhood: what the pediatrician needs to know","volume":"26","author":"Buchanan","year":"2005","journal-title":"Pediatr Rev."},{"issue":"3","key":"2022081115222672400_B2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/ajh.21616","article-title":"The incidence of immune 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