{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:36:36Z","timestamp":1790818596741,"version":"4.1.0"},"reference-count":63,"publisher":"American Society of Hematology","issue":"8","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During embryonic development, multiple waves of hematopoietic progenitors with distinct lineage potential are differentially regulated in time and space. Two different waves of thymic progenitors colonize the fetal thymus where they contribute to thymic organogenesis and homeostasis. The origin, the lineage differentiation potential of the first wave, and their relative contribution in shaping the thymus architecture, remained, however, unclear. Here, we show that the first wave of thymic progenitors comprises a unique population of bipotent T and innatel lymphoid cells (T\/ILC), generating a lymphoid tissue inducer cells (LTi's), in addition to invariant V\u03b35+ T cells. Transcriptional analysis revealed that innate lymphoid gene signatures and, more precisely, the LTi-associated transcripts were expressed in the first, but not in the second, wave of thymic progenitors. Depletion of early thymic progenitors in a temporally controlled manner showed that the progeny of the first wave is indispensable for the differentiation of autoimmune regulator\u2013expressing medullary thymic epithelial cells (mTECs). We further show that these progenitors are of strict hematopoietic stem cell origin, despite the overlap between lymphopoiesis initiation and the transient expression of lymphoid-associated transcripts in yolk sac (YS) erythromyeloid-restricted precursors. Our work highlights the relevance of the developmental timing on the emergence of different lymphoid subsets, required for the establishment of a functionally diverse immune system.<\/jats:p>","DOI":"10.1182\/blood.2020006779","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T01:56:31Z","timestamp":1602035791000},"page":"1024-1036","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":57,"title":["A wave of bipotent T\/ILC-restricted progenitors shapes the embryonic thymus microenvironment in a time-dependent manner"],"prefix":"10.1182","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-0358","authenticated-orcid":false,"given":"Ramy","family":"Elsaid","sequence":"first","affiliation":[{"name":"1Unit of Lymphopoiesis, Immunology Department, Institut Pasteur, Paris, France;"},{"name":"2Unit\u00e9 1223, INSERM, Paris, France;"},{"name":"3Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Meunier","sequence":"additional","affiliation":[{"name":"1Unit of Lymphopoiesis, Immunology Department, Institut Pasteur, Paris, France;"},{"name":"2Unit\u00e9 1223, INSERM, Paris, France;"},{"name":"3Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Burlen-Defranoux","sequence":"additional","affiliation":[{"name":"1Unit of Lymphopoiesis, Immunology Department, Institut Pasteur, Paris, France;"},{"name":"2Unit\u00e9 1223, INSERM, Paris, France;"},{"name":"3Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1312-7601","authenticated-orcid":false,"given":"Francisca","family":"Soares-da-Silva","sequence":"additional","affiliation":[{"name":"1Unit of 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