{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:26:24Z","timestamp":1790083584221,"version":"4.0.1"},"reference-count":30,"publisher":"American Society of Hematology","issue":"10","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Given advanced age, comorbidities, and immune dysfunction, chronic lymphocytic leukemia (CLL) patients may be at particularly high risk of infection and poor outcomes related to coronavirus disease 2019 (COVID-19). Robust analysis of outcomes for CLL patients, particularly examining effects of baseline characteristics and CLL-directed therapy, is critical to optimally manage CLL patients through this evolving pandemic. CLL patients diagnosed with symptomatic COVID-19 across 43 international centers (n = 198) were included. Hospital admission occurred in 90%. Median age at COVID-19 diagnosis was 70.5 years. Median Cumulative Illness Rating Scale score was 8 (range, 4-32). Thirty-nine percent were treatment naive (\u201cwatch and wait\u201d), while 61% had received \u22651 CLL-directed therapy (median, 2; range, 1-8). Ninety patients (45%) were receiving active CLL therapy at COVID-19 diagnosis, most commonly Bruton tyrosine kinase inhibitors (BTKi\u2019s; n = 68\/90 [76%]). At a median follow-up of 16 days, the overall case fatality rate was 33%, though 25% remain admitted. Watch-and-wait and treated cohorts had similar rates of admission (89% vs 90%), intensive care unit admission (35% vs 36%), intubation (33% vs 25%), and mortality (37% vs 32%). CLL-directed treatment with BTKi\u2019s at COVID-19 diagnosis did not impact survival (case fatality rate, 34% vs 35%), though the BTKi was held during the COVID-19 course for most patients. These data suggest that the subgroup of CLL patients admitted with COVID-19, regardless of disease phase or treatment status, are at high risk of death. Future epidemiologic studies are needed to assess severe acute respiratory syndrome coronavirus 2 infection risk, these data should be validated independently, and randomized studies of BTKi\u2019s in COVID-19 are needed to provide definitive evidence of benefit.<\/jats:p>","DOI":"10.1182\/blood.2020006965","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T18:56:14Z","timestamp":1595271374000},"page":"1134-1143","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":282,"title":["Outcomes of COVID-19 in patients with CLL: a multicenter international experience"],"prefix":"10.1182","volume":"136","author":[{"given":"Anthony R.","family":"Mato","sequence":"first","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey E.","family":"Roeker","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Lamanna","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2088-0899","authenticated-orcid":false,"given":"John N.","family":"Allan","sequence":"additional","affiliation":[{"name":"New York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Leslie","sequence":"additional","affiliation":[{"name":"John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Pagel","sequence":"additional","affiliation":[{"name":"Swedish Cancer Institute, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krish","family":"Patel","sequence":"additional","affiliation":[{"name":"Swedish Cancer Institute, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Osterborg","sequence":"additional","affiliation":[{"name":"Karolinska Institute, Solna, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wojenski","sequence":"additional","affiliation":[{"name":"Robert H. 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