{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:14:02Z","timestamp":1793333642828,"version":"4.5.0"},"reference-count":66,"publisher":"American Society of Hematology","issue":"4","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Traumatic brain injury-induced coagulopathy (TBI-IC) causes life-threatening secondary intracranial bleeding. Its pathogenesis differs mechanistically from that of coagulopathy arising from extracranial injuries and hemorrhagic shock, but it remains poorly understood. We report results of a study designed to test the hypothesis that von Willebrand factor (VWF) released during acute TBI is intrinsically hyperadhesive because its platelet-binding A1-domain is exposed and contributes to TBI-induced vascular leakage and consumptive coagulopathy. This hyperadhesive VWF can be selectively blocked by a VWF A2-domain protein to prevent TBI-IC and to improve neurological function with a minimal risk of bleeding. We demonstrated that A2 given through intraperitoneal injection or IV infusion reduced TBI-induced death by &amp;gt;50% and significantly improved the neurological function of C57BL\/6J male mice subjected to severe lateral fluid percussion injury. A2 protected the endothelium from extracellular vesicle-induced injury, reducing TBI-induced platelet activation and microvesiculation, and preventing a TBI-induced hypercoagulable state. A2 achieved this therapeutic efficacy by specifically blocking the A1 domain exposed on the hyperadhesive VWF released during acute TBI. These results suggest that VWF plays a causal role in the development of TBI-IC and is a therapeutic target for this life-threatening complication of TBI.<\/jats:p>","DOI":"10.1182\/blood.2020007364","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T14:53:36Z","timestamp":1596639216000},"page":"544-555","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":41,"title":["Conformation-dependent blockage of activated VWF improves outcomes of traumatic brain injury in mice"],"prefix":"10.1182","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3395-9923","authenticated-orcid":false,"given":"Xin","family":"Xu","sequence":"first","affiliation":[{"name":"Bloodworks Research Institute, Seattle, WA;"},{"name":"Departments of Neurosurgery, Neurology, and Obstetrics & Gynecology, Tianjin Medical University General Hospital, Tianjin, China;"},{"name":"Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medical Sciences, and the Gansu Provincial Key Laboratory of Preclinical Study for New Drug Development, Lanzhou University, Lanzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, the First Affiliated Hospital, University of Science and Technology, Hefei, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Houck","sequence":"additional","affiliation":[{"name":"Bloodworks Research Institute, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Hilton","sequence":"additional","affiliation":[{"name":"Bloodworks Research Institute, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Zhou","sequence":"additional","affiliation":[{"name":"Bloodworks Research Institute, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Wu","sequence":"additional","affiliation":[{"name":"Bloodworks Research Institute, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cha","family":"Han","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Neurology, and Obstetrics & Gynecology, Tianjin Medical University General Hospital, Tianjin, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchen","family":"Yang","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Neurology, and Obstetrics & Gynecology, Tianjin Medical University General Hospital, Tianjin, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Bloodworks Research Institute, Seattle, WA;"},{"name":"NanoString Technologies, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Dong","family":"Shi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Neurology, and Obstetrics & Gynecology, Tianjin Medical University General Hospital, Tianjin, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Stolla","sequence":"additional","affiliation":[{"name":"Bloodworks Research Institute, Seattle, WA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX;"},{"name":"Center for Translational Research on Inflammatory Diseases, Michael E. 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