{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:40:08Z","timestamp":1790707208902,"version":"4.1.0"},"reference-count":46,"publisher":"American Society of Hematology","issue":"13","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The mutational landscape of gray zone lymphoma (GZL) has not yet been established, and differences from related entities are largely unknown. Here, we studied coding sequence mutations of 50 Epstein-Barr virus (EBV)-negative GZLs and 20 polymorphic EBV+ diffuse large B-cell lymphoma (DLBCL) not otherwise specified (poly-EBV-L) in comparison with classical Hodgkin lymphoma (cHL), primary mediastinal large B-cell lymphoma (PMBCL), and DLBCL. Exomes of 21 GZL and 7 poly-EBV-L cases, along with paired constitutional DNA, were analyzed as a discovery cohort, followed by targeted sequencing of 217 genes in an extension cohort of 29 GZL and 13 poly-EBV-L cases. GZL cases with thymic niche involvement (anterior mediastinal mass) exhibited a mutation profile closely resembling cHL and PMBCL, with SOCS1 (45%), B2M (45%), TNFAIP3 (35%), GNA13 (35%), LRRN3 (32%), and NFKBIA (29%) being the most recurrently mutated genes. In contrast, GZL cases without thymic niche involvement (n = 18) had a significantly distinct pattern that was enriched in mutations related to apoptosis defects (TP53 [39%], BCL2 [28%], BIRC6 [22%]) and depleted in GNA13, XPO1, or NF-\u03baB signaling pathway mutations (TNFAIP3, NFKBIE, IKBKB, NFKBIA). They also exhibited more BCL2\/BCL6 rearrangements compared with thymic GZL. Poly-EBV-L cases presented a distinct mutational profile, including STAT3 mutations and a significantly lower coding mutation load in comparison with EBV\u2212 GZL. Our study highlights characteristic mutational patterns in GZL associated with presentation in the thymic niche, suggesting a common cell of origin and disease evolution overlapping with related anterior mediastinal lymphomas.<\/jats:p>","DOI":"10.1182\/blood.2020007507","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T23:46:58Z","timestamp":1600818418000},"page":"1765-1776","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":104,"title":["Mutational landscape of gray zone lymphoma"],"prefix":"10.1182","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1942-9304","authenticated-orcid":false,"given":"Cl\u00e9mentine","family":"Sarkozy","sequence":"first","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"},{"name":"INSERM Unit\u00e9 Mixte de Recherche (UMR) S1052, Centre National de la Recherche UMR 5286, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy S.","family":"Hung","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Chavez","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerben","family":"Duns","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Takata","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Chong","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6782-8361","authenticated-orcid":false,"given":"Tomohiro","family":"Aoki","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aixiang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Miyata-Takata","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad\u00e8le","family":"Telenius","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham W.","family":"Slack","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry Jo","family":"Molina","sequence":"additional","affiliation":[{"name":"Pathology Department, Necker Enfants Malades Hospital, Universit\u00e9 Paris Descartes, Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2013HP), Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Ben-Neriah","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-9391","authenticated-orcid":false,"given":"Pedro","family":"Farinha","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Dartigues","sequence":"additional","affiliation":[{"name":"Pathology Department, Gustave Roussy, Universit\u00e9 Paris-Saclay, INSERM U1170, Villejuif, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Damotte","sequence":"additional","affiliation":[{"name":"Pathology Department, Groupe Hospitalier Cochin, AP-HP, Paris, France;"},{"name":"INSERM U1138, Paris Descartes University-Sorbonne Paris Cit\u00e9, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Mottok","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-8666","authenticated-orcid":false,"given":"Gilles A.","family":"Salles","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 Mixte de Recherche (UMR) S1052, Centre National de la Recherche UMR 5286, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon, France;"},{"name":"D\u00e9partement d\u2019H\u00e9matologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre B\u00e9nite Cedex, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1156-8983","authenticated-orcid":false,"given":"Rene-Olivier","family":"Casasnovas","sequence":"additional","affiliation":[{"name":"Department of Hematology, Fran\u00e7ois Mitterrand University Hospital, INSERM U1231, Dijon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5835-9863","authenticated-orcid":false,"given":"Kerry J.","family":"Savage","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Laurent","sequence":"additional","affiliation":[{"name":"Institut Universitaire du Cancer-Oncopole de Toulouse, CHU Toulouse, INSERM U1037, Centre de Recherche en Cancerologie de Toulouse-Purpan, Toulouse-Purpan, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Scott","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Traverse-Glehen","sequence":"additional","affiliation":[{"name":"INSERM Unit\u00e9 Mixte de Recherche (UMR) S1052, Centre National de la Recherche UMR 5286, Centre de Recherche en Canc\u00e9rologie de Lyon, Lyon, France;"},{"name":"D\u00e9partement de Pathologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre B\u00e9nite Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9842-9750","authenticated-orcid":false,"given":"Christian","family":"Steidl","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"3","key":"2021040115261030100_B1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/PAS.0000000000001198","article-title":"Gray-zone lymphoma between cHL and large B-cell lymphoma: a histopathologic series from the LYSA","volume":"43","author":"Sarkozy","year":"2019","journal-title":"Am J Surg Pathol"},{"issue":"26","key":"2021040115261030100_B2","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1182\/bloodadvances.2017009472","article-title":"Clinicopathologic consensus study of gray zone lymphoma with features intermediate between DLBCL and classical HL","volume":"1","author":"Pilichowska","year":"2017","journal-title":"Blood Adv"},{"issue":"20","key":"2021040115261030100_B3","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the World Health Organization classification of lymphoid neoplasms","volume":"127","author":"Swerdlow","year":"2016","journal-title":"Blood"},{"issue":"12","key":"2021040115261030100_B4","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1038\/modpathol.2011.116","article-title":"Gray zone lymphoma: chromosomal aberrations with immunophenotypic and clinical correlations","volume":"24","author":"Eberle","year":"2011","journal-title":"Mod Pathol"},{"issue":"1","key":"2021040115261030100_B5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1365-2559.2005.02175.x","article-title":"Large B-cell lymphoma with Hodgkin\u2019s features","volume":"47","author":"Garc\u00eda","year":"2005","journal-title":"Histopathology"},{"issue":"5","key":"2021040115261030100_B6","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/modpathol.2011.200","article-title":"The spectrum of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: a description of 10 cases","volume":"25","author":"Gualco","year":"2012","journal-title":"Mod Pathol"},{"issue":"3","key":"2021040115261030100_B7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11899-012-0130-5","article-title":"Gray zone lymphoma: better treated like Hodgkin lymphoma or mediastinal large B-cell lymphoma?","volume":"7","author":"Dunleavy","year":"2012","journal-title":"Curr Hematol Malig Rep"},{"issue":"4","key":"2021040115261030100_B8","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3324\/haematol.2010.033167","article-title":"Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin\u2019s lymphoma and primary mediastinal large B-cell lymphoma","volume":"96","author":"Eberle","year":"2011","journal-title":"Haematologica"},{"issue":"11","key":"2021040115261030100_B9","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1182\/bloodadvances.2020001923","article-title":"Gene expression profiling of gray zone lymphoma","volume":"4","author":"Sarkozy","year":"2020","journal-title":"Blood Adv"},{"issue":"2","key":"2021040115261030100_B10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1158\/2643-3230.BCD-20-0009","article-title":"Gene expression profiling of mediastinal gray zone lymphoma and its relationship to primary mediastinal B-cell lymphoma and classical Hodgkin lymphoma","volume":"1","author":"Pittaluga","year":"2020","journal-title":"Blood Cancer Discov"},{"issue":"4","key":"2021040115261030100_B11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/his.13100","article-title":"Grey zone lymphoma with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: a clinicopathological study of 14 Epstein-Barr virus-positive cases","volume":"70","author":"Elsayed","year":"2017","journal-title":"Histopathology"},{"issue":"7","key":"2021040115261030100_B12","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1182\/blood-2015-02-630632","article-title":"EBV-positive large B-cell lymphomas in young patients: a nodal lymphoma with evidence for a tolerogenic immune environment","volume":"126","author":"Nicolae","year":"2015","journal-title":"Blood"},{"issue":"12","key":"2021040115261030100_B13","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1182\/blood-2008-07-168096","article-title":"Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome","volume":"113","author":"Chetaille","year":"2009","journal-title":"Blood"},{"issue":"3","key":"2021040115261030100_B14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/ejh.13274","article-title":"The tumour microenvironment is immuno-tolerogenic and a principal determinant of patient outcome in EBV-positive diffuse large B-cell lymphoma","volume":"103","author":"Keane","year":"2019","journal-title":"Eur J Haematol"},{"issue":"7","key":"2021040115261030100_B15","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1038\/s41375-019-0380-5","article-title":"Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas","volume":"33","author":"Kataoka","year":"2019","journal-title":"Leukemia"},{"issue":"4","key":"2021040115261030100_B16","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.3109\/10428194.2014.944522","article-title":"Prevalence of targetable oncogenic mutations and genomic alterations in Epstein-Barr virus-associated diffuse large B-cell lymphoma of the elderly","volume":"56","author":"Gebauer","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"2021040115261030100_B17","article-title":"Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM.","author":"Li"},{"issue":"3","key":"2021040115261030100_B18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat Biotechnol"},{"issue":"14","key":"2021040115261030100_B19","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1093\/bioinformatics\/bts271","article-title":"Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs","volume":"28","author":"Saunders","year":"2012","journal-title":"Bioinformatics"},{"issue":"17","key":"2021040115261030100_B20","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1093\/bioinformatics\/btp373","article-title":"VarScan: variant detection in massively parallel sequencing of individual and pooled samples","volume":"25","author":"Koboldt","year":"2009","journal-title":"Bioinformatics"},{"issue":"26","key":"2021040115261030100_B21","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1182\/blood.2019002067","article-title":"Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade","volume":"134","author":"Chapuy","year":"2019","journal-title":"Blood"},{"issue":"10","key":"2021040115261030100_B22","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1182\/blood.2019001126","article-title":"Integrative genomic analysis identifies key pathogenic mechanisms in primary mediastinal large B-cell lymphoma","volume":"134","author":"Mottok","year":"2019","journal-title":"Blood"},{"issue":"22","key":"2021040115261030100_B23","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1182\/blood-2017-11-814913","article-title":"Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma","volume":"131","author":"Tiacci","year":"2018","journal-title":"Blood"},{"issue":"7","key":"2021040115261030100_B24","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1182\/blood-2014-11-610436","article-title":"Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells","volume":"125","author":"Reichel","year":"2015","journal-title":"Blood"},{"issue":"12","key":"2021040115261030100_B25","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1158\/1078-0432.CCR-15-2305","article-title":"Next-generation sequencing in diffuse large B-cell lymphoma highlights molecular divergence and therapeutic opportunities: a LYSA study","volume":"22","author":"Dubois","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"67","key":"2021040115261030100_B26","doi-asserted-by":"crossref","first-page":"111386","DOI":"10.18632\/oncotarget.22799","article-title":"Analysis of the mutational landscape of classic Hodgkin lymphoma identifies disease heterogeneity and potential therapeutic targets","volume":"8","author":"Mata","year":"2017","journal-title":"Oncotarget"},{"issue":"5","key":"2021040115261030100_B27","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41591-018-0016-8","article-title":"Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes [published correction appears in Nat Med. 2018;24(8):1290-1291]","volume":"24","author":"Chapuy","year":"2018","journal-title":"Nat Med"},{"issue":"15","key":"2021040115261030100_B28","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1056\/NEJMoa1801445","article-title":"Genetics and pathogenesis of diffuse large B-cell lymphoma","volume":"378","author":"Schmitz","year":"2018","journal-title":"N Engl J Med"},{"issue":"23","key":"2021040115261030100_B29","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1182\/bloodadvances.2019001012","article-title":"Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion","volume":"3","author":"Wienand","year":"2019","journal-title":"Blood Adv"},{"issue":"2","key":"2021040115261030100_B30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cell.2017.09.027","article-title":"Genetic and functional drivers of diffuse large B cell lymphoma","volume":"171","author":"Reddy","year":"2017","journal-title":"Cell"},{"issue":"4","key":"2021040115261030100_B31","doi-asserted-by":"crossref","first-page":"e1004873","DOI":"10.1371\/journal.pcbi.1004873","article-title":"CNVkit: genome-wide copy number detection and visualization from targeted DNA sequencing","volume":"12","author":"Talevich","year":"2016","journal-title":"PLOS Comput Biol"},{"issue":"4","key":"2021040115261030100_B32","doi-asserted-by":"crossref","first-page":"R41","DOI":"10.1186\/gb-2011-12-4-r41","article-title":"GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers","volume":"12","author":"Mermel","year":"2011","journal-title":"Genome Biol"},{"issue":"7457","key":"2021040115261030100_B33","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature12213","article-title":"Mutational heterogeneity in cancer and the search for new cancer-associated genes","volume":"499","author":"Lawrence","year":"2013","journal-title":"Nature"},{"issue":"6","key":"2021040115261030100_B34","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1182\/blood-2017-08-737361","article-title":"Chromatin modifying gene mutations in follicular lymphoma","volume":"131","author":"Green","year":"2018","journal-title":"Blood"},{"issue":"7718","key":"2021040115261030100_B35","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41586-018-0290-0","article-title":"A multiprotein supercomplex controlling oncogenic signalling in lymphoma","volume":"560","author":"Phelan","year":"2018","journal-title":"Nature"},{"issue":"6","key":"2021040115261030100_B36","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/leu.2011.378","article-title":"BCL2 mutations in diffuse large B-cell lymphoma","volume":"26","author":"Schuetz","year":"2012","journal-title":"Leukemia"},{"issue":"18","key":"2021040115261030100_B37","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1182\/blood-2017-09-808907","article-title":"Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation","volume":"131","author":"Vigan\u00f2","year":"2018","journal-title":"Blood"},{"issue":"22","key":"2021040115261030100_B38","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1182\/blood-2018-05-851154","article-title":"Molecular classification of primary mediastinal large B-cell lymphoma using routinely available tissue specimens","volume":"132","author":"Mottok","year":"2018","journal-title":"Blood"},{"issue":"12","key":"2021040115261030100_B39","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1182\/blood-2018-09-871418","article-title":"Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma","volume":"133","author":"Grande","year":"2019","journal-title":"Blood"},{"issue":"2","key":"2021040115261030100_B40","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/bjh.16331","article-title":"Composite and sequential lymphoma between classical Hodgkin lymphoma and primary mediastinal lymphoma\/diffuse large B-cell lymphoma, a clinico-pathological series of 25 cases","volume":"189","author":"Aussedat","year":"2020","journal-title":"Br J Haematol"},{"issue":"4","key":"2021040115261030100_B41","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s12308-009-0053-9","article-title":"Gray zones around diffuse large B cell lymphoma. Conclusions based on the workshop of the XIV meeting of the European Association for Hematopathology and the Society of Hematopathology in Bordeaux, France","volume":"2","author":"Quintanilla-Martinez","year":"2009","journal-title":"J Hematop"},{"issue":"9","key":"2021040115261030100_B42","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1158\/1078-0432.CCR-13-3157","article-title":"Prevalence and clinical implications of epstein-barr virus infection in de novo diffuse large B-cell lymphoma in Western countries [published correction appears in Clin Cancer Res. 2014;20(18):4974]","volume":"20","author":"Ok","year":"2014","journal-title":"Clin Cancer Res"},{"issue":"2","key":"2021040115261030100_B43","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1084\/jem.191.2.395","article-title":"Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin\u2019s lymphoma","volume":"191","author":"Jungnickel","year":"2000","journal-title":"J Exp Med"},{"issue":"2","key":"2021040115261030100_B44","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/bjh.16342","article-title":"Impact of treatment variability and clinicopathological characteristics on survival in patients with Epstein-Barr-virus positive diffuse large B cell lymphoma","volume":"189","author":"Witte","year":"2020","journal-title":"Br J Haematol"},{"issue":"18","key":"2021040115261030100_B45","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1038\/sj.onc.1209151","article-title":"Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation","volume":"25","author":"Weniger","year":"2006","journal-title":"Oncogene"},{"issue":"1","key":"2021040115261030100_B46","doi-asserted-by":"crossref","first-page":"35","DOI":"10.18632\/oncotarget.774","article-title":"SOCS1 mutation subtypes predict divergent outcomes in diffuse large B-cell lymphoma (DLBCL) patients","volume":"4","author":"Schif","year":"2013","journal-title":"Oncotarget"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/137\/13\/1765\/1803940\/bloodbld2020007507.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/ashpublications.org\/blood\/article-pdf\/137\/13\/1765\/1803940\/bloodbld2020007507.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T15:37:35Z","timestamp":1617291455000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/137\/13\/1765\/463845\/Mutational-landscape-of-gray-zone-lymphoma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":46,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2021,4,1]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2020007507","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]}}}