{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:23:19Z","timestamp":1774664599214,"version":"3.50.1"},"reference-count":32,"publisher":"American Society of Hematology","issue":"19","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute platelet transfusion after intracerebral hemorrhage (ICH) given in efforts to reverse antiplatelet medication effects and prevent ongoing bleeding does not appear to improve outcome and may be associated with harm. Although the underlying mechanisms are unclear, the influence of ABO-incompatible platelet transfusions on ICH outcomes has not been investigated. We hypothesized that patients with ICH who receive ABO-incompatible platelet transfusions would have worse platelet recovery (using absolute count increment [ACI]) and neurological outcomes (mortality and poor modified Rankin Scale [mRS 4-6]) than those receiving ABO-compatible transfusions. In a single-center cohort of consecutively admitted patients with ICH, we identified 125 patients receiving acute platelet transfusions, of whom 47 (38%) received an ABO-incompatible transfusion. Using quantile regression, we identified an association of ABO-incompatible platelet transfusion with lower platelet recovery (ACI, 2 \u00d7 103cells per \u03bcL vs 15 \u00d7 103cells per \u03bcL; adjusted coefficient \u03b2, \u221219; 95% confidence interval [CI], \u221235.55 to \u22124.44; P = .01). ABO-incompatible platelet transfusion was also associated with increased odds of mortality (adjusted odds ratio [OR], 2.59; 95% CI, 1.00-6.73; P = .05) and poor mRS (adjusted OR, 3.61; 95% CI, 0.97-13.42; P = .06); however, these estimates were imprecise. Together, these findings suggest the importance of ABO compatibility for platelet transfusions for ICH, but further investigation into the mechanism(s) underlying these observations is required.<\/jats:p>","DOI":"10.1182\/blood.2020008381","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T22:53:52Z","timestamp":1614639232000},"page":"2699-2703","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":38,"title":["Impacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage"],"prefix":"10.1182","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6506-6017","authenticated-orcid":false,"given":"Jessica","family":"Magid-Bernstein","sequence":"first","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5425-8849","authenticated-orcid":false,"given":"Charles B.","family":"Beaman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Carvalho-Poyraz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia","family":"Boehme","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons,"},{"name":"Department of Epidemiology, Mailman School of Public Health,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldad A.","family":"Hod","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard O.","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2562-1156","authenticated-orcid":false,"given":"Mitchell S. V.","family":"Elkind","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons,"},{"name":"Department of Epidemiology, Mailman School of Public Health,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soojin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5893-8531","authenticated-orcid":false,"given":"Jan","family":"Claassen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vagelos College of Physicians and Surgeons,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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