{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:20:36Z","timestamp":1790824836687,"version":"4.1.0"},"reference-count":25,"publisher":"American Society of Hematology","issue":"20","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Anti-CD20 monoclonal antibodies are widely used for the treatment of hematological malignancies or autoimmune disease but may be responsible for a secondary humoral deficiency. In the context of COVID-19 infection, this may prevent the elicitation of a specific SARS-CoV-2 antibody response. We report a series of 17 consecutive patients with profound B-cell lymphopenia and prolonged COVID-19 symptoms, negative immunoglobulin G (IgG)-IgM SARS-CoV-2 serology, and positive RNAemia measured by digital polymerase chain reaction who were treated with 4 units of COVID-19 convalescent plasma. Within 48 hours of transfusion, all but 1 patient experienced an improvement of clinical symptoms. The inflammatory syndrome abated within a week. Only 1 patient who needed mechanical ventilation for severe COVID-19 disease died of bacterial pneumonia. SARS-CoV-2 RNAemia decreased to below the sensitivity threshold in all 9 evaluated patients. In 3 patients, virus-specific T-cell responses were analyzed using T-cell enzyme-linked immunospot assay before convalescent plasma transfusion. All showed a maintained SARS-CoV-2 T-cell response and poor cross-response to other coronaviruses. No adverse event was reported. Convalescent plasma with anti\u2013SARS-CoV-2 antibodies appears to be a very promising approach in the context of protracted COVID-19 symptoms in patients unable to mount a specific humoral response to SARS-CoV-2.<\/jats:p>","DOI":"10.1182\/blood.2020008423","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T01:58:36Z","timestamp":1600739916000},"page":"2290-2295","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":265,"title":["Convalescent plasma therapy for B-cell\u2013depleted patients with protracted COVID-19"],"prefix":"10.1182","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3354-332X","authenticated-orcid":false,"given":"Thomas","family":"Hueso","sequence":"first","affiliation":[{"name":"Hematology Department, Gustave Roussy, Villejuif, France;"},{"name":"Paris-Sud University, Paris-Saclay University, Le Kremlin-Bic\u00eatre, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Pouderoux","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Croix Rousse Hospital, Hospices Civils de Lyon, Lyon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"P\u00e9r\u00e9","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), Paris, France;"},{"name":"Universit\u00e9 de Paris, INSERM U970, Paris Cardiovascular Research Center, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Lise","family":"Beaumont","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Saint-Antoine Hospital, AP-HP, Paris, 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