{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:54:22Z","timestamp":1790744062671,"version":"4.1.0"},"reference-count":55,"publisher":"American Society of Hematology","issue":"1","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Follicular lymphoma (FL) originates in the lymph nodes (LNs) and infiltrates bone marrow (BM) early in the course of the disease. BM FL B cells are characterized by a lower cytological grade, decreased proliferation, and a specific phenotypic and subclonal profile. Mesenchymal stromal cells (MSCs) obtained from FL BM display a specific gene expression profile (GEP), including enrichment for a lymphoid stromal cell signature, and an increased capacity to sustain FL B-cell growth. However, the mechanisms triggering the formation of the medullar FL permissive stromal niche have not been identified. In the current work, we demonstrate that FL B cells produce extracellular vesicles (EVs) that can be internalized by BM-MSCs, making them more efficient to support FL B-cell survival and quiescence. Accordingly, EVs purified from FL BM plasma activate transforming growth factor \u03b2\u2013dependent and independent pathways in BM-MSCs and modify their GEP, triggering an upregulation of factors classically associated with hematopoietic stem cell niche, including CXCL12 and angiopoietin-1. Moreover, we provide the first characterization of BM FL B-cell GEP, allowing the definition of the landscape of molecular interactions they could engage with EV-primed BM-MSCs. This work identifies FL-derived EVs as putative mediators of BM stroma polarization and supports further investigation of their clinical interest for targeting the crosstalk between BM-MSCs and malignant B cells.<\/jats:p>","DOI":"10.1182\/blood.2020008791","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T07:43:29Z","timestamp":1619077409000},"page":"57-70","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":30,"title":["Extracellular vesicles shed by follicular lymphoma B cells promote polarization of the bone marrow stromal cell niche"],"prefix":"10.1182","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2438-7735","authenticated-orcid":false,"given":"Erwan","family":"Dumontet","sequence":"first","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR) 1236, INSERM, Universit\u00e9 Rennes, EFS Bretagne, Laboratoires d'Excellence \"Immunotherapy-Graft-Oncology\" (LabEx 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