{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:21:15Z","timestamp":1790911275106,"version":"4.1.0"},"reference-count":51,"publisher":"American Society of Hematology","issue":"16","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of mature T-cell neoplasms characterized by the accumulation of clonal malignant CD4+ T cells in the skin. The most common variant of CTCL, mycosis fungoides (MF ), is confined to the skin in early stages but can be accompanied by extracutaneous dissemination of malignant T cells to the blood and lymph nodes in advanced stages of disease. S\u00e9zary syndrome (SS), a leukemic form of disease, is characterized by significant blood involvement. Little is known about the transcriptional and genomic relationship between skin- and blood-residing malignant T cells in CTCL. To identify and interrogate malignant clones in matched skin and blood from patients with leukemic MF and SS, we combine T-cell receptor clonotyping with quantification of gene expression and cell surface markers at the single cell level. Our data reveal clonal evolution at a transcriptional and genetic level within the malignant populations of individual patients. We highlight highly consistent transcriptional signatures delineating skin- and blood-derived malignant T cells. Analysis of these 2 populations suggests that environmental cues, along with genetic aberrations, contribute to transcriptional profiles of malignant T cells. Our findings indicate that the skin microenvironment in CTCL promotes a transcriptional response supporting rapid malignant expansion, as opposed to the quiescent state observed in the blood, potentially influencing efficacy of therapies. These results provide insight into tissue-specific characteristics of cancerous cells and underscore the need to address the patients\u2019 individual malignant profiles at the time of therapy to eliminate all subclones.<\/jats:p>","DOI":"10.1182\/blood.2020009346","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T16:31:17Z","timestamp":1625675477000},"page":"1456-1464","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":76,"title":["Multimodal single-cell analysis of cutaneous T-cell lymphoma reveals distinct subclonal tissue-dependent signatures"],"prefix":"10.1182","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-9051","authenticated-orcid":false,"given":"Alberto","family":"Herrera","sequence":"first","affiliation":[{"name":"Department of Pathology, New York University School of Medicine, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0778-8238","authenticated-orcid":false,"given":"Anthony","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Genetic and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT;"},{"name":"Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9737-6394","authenticated-orcid":false,"given":"Eleni P.","family":"Mimitou","sequence":"additional","affiliation":[{"name":"Technology Innovation Laboratory, New York Genome Center, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5703-5472","authenticated-orcid":false,"given":"Angelina","family":"Seffens","sequence":"additional","affiliation":[{"name":"Department of 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Medicine, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0152-0863","authenticated-orcid":false,"given":"Kelly V.","family":"Ruggles","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1072-6994","authenticated-orcid":false,"given":"Jose U.","family":"Scher","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Hymes","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo-Ann","family":"Latkowski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, New York University School of Medicine, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3135-5624","authenticated-orcid":false,"given":"Niels","family":"\u00d8dum","sequence":"additional","affiliation":[{"name":"LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall E.","family":"Kadin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Boston University and Roger Williams Medical Center, Brown University, Providence, RI;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2842-8503","authenticated-orcid":false,"given":"Zhengqing","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa J.","family":"Geskin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Columbia University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-1647","authenticated-orcid":false,"given":"Peter","family":"Smibert","sequence":"additional","affiliation":[{"name":"Technology Innovation Laboratory, New York Genome Center, New York, NY;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7180-6384","authenticated-orcid":false,"given":"Terkild B.","family":"Buus","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University School of Medicine, New York, NY;"},{"name":"LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, 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