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Furthermore, we showed that OBF1, OCT2, and OCT1 bind widely to the promoters or enhancers of genes involved in GC formation in mouse and human GC B cells. Short hairpin RNA knockdown experiments demonstrated that OCT1, OCT2, and OBF1 regulate each other and are essential for proliferation of GC-derived lymphoma cell lines. OBF1 downregulation disrupts the GC transcriptional program: genes involved in GC maintenance, such as BCL6, are downregulated, whereas genes related to exit from the GC program, such as IRF4, are upregulated. Ectopic expression of BCL6 does not restore the proliferation of GC-derived lymphoma cells depleted of OBF1 unless IRF4 is also depleted, indicating that OBF1 controls an essential regulatory node in GC differentiation.<\/jats:p>","DOI":"10.1182\/blood.2020010175","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T21:12:43Z","timestamp":1611609163000},"page":"2920-2934","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":43,"title":["OBF1 and Oct factors control the germinal center transcriptional program"],"prefix":"10.1182","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9521-8867","authenticated-orcid":false,"given":"Shuang","family":"Song","sequence":"first","affiliation":[{"name":"Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland;"},{"name":"Faculty of Sciences 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