{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T11:10:11Z","timestamp":1794049811067,"version":"4.8.0"},"reference-count":57,"publisher":"American Society of Hematology","issue":"22","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mantle cell lymphoma (MCL) is a mature B-cell neoplasm with a heterogeneous clinical and biological behavior. SOX11 oncogenic expression contributes to the aggressiveness of these tumors by different mechanisms, including tumor and stromal cell interactions. However, the precise composition of the immune cell microenvironment of MCL, its possible relationship to SOX11 expression, and how it may contribute to tumor behavior is not well known. Here, we performed an integrative transcriptome analysis of 730 immune-related genes combined with the immune cell phenotype analysis by immunohistochemistry in SOX11+ and SOX11\u2212 primary nodal MCL cases and non-neoplastic reactive lymph nodes. SOX11+ MCL had a significant lower T-cell intratumoral infiltration compared with negative cases. A reduced expression of MHCI\/II-like and T-cell costimulation and signaling activation related transcripts was significantly associated with poor clinical outcome. Moreover, we identified CD70 as a SOX11 direct target gene, whose overexpression was induced in SOX11+, but not SOX11\u2212 tumor cells by CD40L in vitro. CD70 was overexpressed in primary SOX11+ MCL and it was associated with an immune unbalance of the tumor microenvironment characterized by increased number of effector regulatory T (Treg) cell infiltration, higher proliferation, and aggressive clinical course. CD27 was expressed with moderate to strong intensity in 76% of cases. Overall, our results suggest that SOX11 expression in MCL is associated with an immunosuppressive microenvironment characterized by CD70 overexpression in tumor cells, increased Treg cell infiltration and downmodulation of antigen processing, and presentation and T-cell activation that could promote MCL progression and represent a potential target for tailored therapies.<\/jats:p>","DOI":"10.1182\/blood.2020010527","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T03:09:01Z","timestamp":1625108941000},"page":"2202-2215","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":60,"title":["SOX11, CD70, and Treg cells configure the tumor immune microenvironment of aggressive mantle cell lymphoma"],"prefix":"10.1182","volume":"138","author":[{"given":"Patricia","family":"Balsas","sequence":"first","affiliation":[{"name":"1Institut d'Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), Barcelona, Spain;"},{"name":"2Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Veloza","sequence":"additional","affiliation":[{"name":"3Hematopathology Section, Department of Anatomic Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillem","family":"Clot","sequence":"additional","affiliation":[{"name":"1Institut d'Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), Barcelona, Spain;"},{"name":"2Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8931-2673","authenticated-orcid":false,"given":"Marta","family":"Sureda-G\u00f3mez","sequence":"additional","affiliation":[{"name":"1Institut d'Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta-Leonor","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"1Institut d'Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0029-7046","authenticated-orcid":false,"given":"Christos","family":"Masaoutis","sequence":"additional","affiliation":[{"name":"3Hematopathology Section, Department of Anatomic Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6794-6456","authenticated-orcid":false,"given":"Gerard","family":"Frigola","sequence":"additional","affiliation":[{"name":"3Hematopathology Section, Department of Anatomic Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Navarro","sequence":"additional","affiliation":[{"name":"1Institut d'Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), Barcelona, Spain;"},{"name":"2Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7192-2385","authenticated-orcid":false,"given":"Silvia","family":"Be\u00e0","sequence":"additional","affiliation":[{"name":"1Institut d'Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), Barcelona, Spain;"},{"name":"2Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Madrid, Spain;"},{"name":"3Hematopathology Section, Department of Anatomic Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-9440","authenticated-orcid":false,"given":"Ferran","family":"Nadeu","sequence":"additional","affiliation":[{"name":"1Institut d'Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), Barcelona, Spain;"},{"name":"2Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gin\u00e9","sequence":"additional","affiliation":[{"name":"1Institut d'Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), Barcelona, Spain;"},{"name":"2Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Madrid, Spain;"},{"name":"4Department of Hematology, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"L\u00f3pez-Guillermo","sequence":"additional","affiliation":[{"name":"1Institut d'Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), Barcelona, Spain;"},{"name":"2Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Madrid, Spain;"},{"name":"4Department of Hematology, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-9017","authenticated-orcid":false,"given":"Antonio","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"1Institut d'Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), Barcelona, Spain;"},{"name":"2Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Madrid, Spain;"},{"name":"3Hematopathology Section, Department of Anatomic Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Ribera-Cortada","sequence":"additional","affiliation":[{"name":"3Hematopathology Section, Department of Anatomic Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Engel","sequence":"additional","affiliation":[{"name":"5Immunology Unit, Department of Biomedical Science, University of Barcelona, Barcelona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-5365","authenticated-orcid":false,"given":"Leticia","family":"Quintanilla-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"6Institute of Pathology and Neuropathology and Comprehensive Cancer Center T\u00fcbingen, University Hospital T\u00fcbingen, Eberhard-Karls-University, T\u00fcbingen, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-4117","authenticated-orcid":false,"given":"Wolfram","family":"Klapper","sequence":"additional","affiliation":[{"name":"7Department of Pathology, Hematopathology Section and Lymph Node Registry, University of Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9850-9793","authenticated-orcid":false,"given":"Elias","family":"Campo","sequence":"additional","affiliation":[{"name":"1Institut d'Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), Barcelona, Spain;"},{"name":"2Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Madrid, Spain;"},{"name":"3Hematopathology Section, Department of Anatomic Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-2874","authenticated-orcid":false,"given":"Virginia","family":"Amador","sequence":"additional","affiliation":[{"name":"1Institut d'Investigacions Biom\u00e8diques August Pi Sunyer (IDIBAPS), Barcelona, Spain;"},{"name":"2Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"key":"2022090722225956600_B1","first-page":"285","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow","year":"2017","edition":"revised 4th ed."},{"issue":"3","key":"2022090722225956600_B2","first-page":"1","article-title":"Mantle cell lymphoma pathology update in the 2016 WHO classification","volume":"3","author":"Veloza","year":"2019","journal-title":"Ann Lymphoma."},{"issue":"8","key":"2022090722225956600_B3","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1080\/10428194.2019.1571205","article-title":"Recent advances and future directions in mantle cell lymphoma research: report of the 2018 mantle cell lymphoma consortium workshop","volume":"60","author":"Kahl","year":"2019","journal-title":"Leuk Lymphoma."},{"issue":"8","key":"2022090722225956600_B4","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1038\/leu.2012.72","article-title":"Non-nodal type of mantle cell lymphoma is a specific biological and clinical subgroup of the disease","volume":"26","author":"Royo","year":"2012","journal-title":"Leukemia."},{"issue":"4","key":"2022090722225956600_B5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1182\/blood-2018-03-838136","article-title":"A gene signature that distinguishes conventional and leukemic nonnodal mantle cell lymphoma helps predict outcome","volume":"132","author":"Clot","year":"2018","journal-title":"Blood."},{"issue":"4","key":"2022090722225956600_B6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1182\/blood-2018-05-853077","article-title":"A tale of two mantle cell lymphomas","volume":"132","author":"Martin","year":"2018","journal-title":"Blood."},{"issue":"4","key":"2022090722225956600_B7","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1158\/0008-5472.CAN-09-3419","article-title":"Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma","volume":"70","author":"Fern\u00e0ndez","year":"2010","journal-title":"Cancer Res."},{"issue":"12","key":"2022090722225956600_B8","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1182\/blood-2012-06-438937","article-title":"SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma","volume":"121","author":"Vegliante","year":"2013","journal-title":"Blood."},{"issue":"7","key":"2022090722225956600_B9","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/leu.2015.355","article-title":"SOX11 defines two different MCL phenotypes by controlling PAX5 and BCL6 expression","volume":"30","author":"Palomero","year":"2016","journal-title":"Leukemia."},{"issue":"20","key":"2022090722225956600_B10","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1182\/blood-2018-02-832535","article-title":"SOX11 augments BCR signaling to drive MCL-like tumor development","volume":"131","author":"Kuo","year":"2018","journal-title":"Blood."},{"issue":"14","key":"2022090722225956600_B11","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1182\/blood-2014-04-569566","article-title":"SOX11 promotes tumor angiogenesis through transcriptional regulation of PDGFA in mantle cell lymphoma","volume":"124","author":"Palomero","year":"2014","journal-title":"Blood."},{"issue":"4","key":"2022090722225956600_B12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1182\/blood-2017-04-776740","article-title":"SOX11 promotes tumor protective microenvironment interactions through CXCR4 and FAK regulation in mantle cell lymphoma","volume":"130","author":"Balsas","year":"2017","journal-title":"Blood."},{"issue":"1","key":"2022090722225956600_B13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3324\/haematol.2017.177162","article-title":"Inhibition of focal adhesion kinase overcomes resistance of mantle cell lymphoma to ibrutinib in the bone marrow microenvironment","volume":"103","author":"Rudelius","year":"2018","journal-title":"Haematologica."},{"issue":"5","key":"2022090722225956600_B14","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/his.13935","article-title":"Increased tumor angiogenesis in SOX11-positive mantle cell lymphoma","volume":"75","author":"Petrakis","year":"2019","journal-title":"Histopathology."},{"issue":"10","key":"2022090722225956600_B15","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/cas.13020","article-title":"Negative prognostic impact of low absolute CD4+ T cell counts in peripheral blood in mantle cell lymphoma","volume":"107","author":"Zhang","year":"2016","journal-title":"Cancer Sci."},{"issue":"23","key":"2022090722225956600_B16","doi-asserted-by":"crossref","first-page":"6096","DOI":"10.1158\/1078-0432.CCR-14-0889","article-title":"T-cell levels are prognostic in mantle cell lymphoma","volume":"20","author":"Nygren","year":"2014","journal-title":"Clin Cancer Res."},{"issue":"2","key":"2022090722225956600_B17","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/sj.leu.2401664","article-title":"Proliferative response of mantle cell lymphoma cells stimulated by CD40 ligation and IL-4","volume":"14","author":"Castillo","year":"2000","journal-title":"Leukemia."},{"issue":"6","key":"2022090722225956600_B18","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1182\/blood.V96.6.2219","article-title":"Soluble CD40 ligand induces selective proliferation of lymphoma cells in primary mantle cell lymphoma cell cultures","volume":"96","author":"Andersen","year":"2000","journal-title":"Blood."},{"issue":"5","key":"2022090722225956600_B19","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.semcancer.2011.09.006","article-title":"The microenvironment in mantle cell lymphoma: cellular and molecular pathways and emerging targeted therapies","volume":"21","author":"Burger","year":"2011","journal-title":"Semin Cancer Biol."},{"issue":"24","key":"2022090722225956600_B20","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1182\/blood-2016-06-720490","article-title":"Rational targeted therapies to overcome microenvironment-dependent expansion of mantle cell lymphoma","volume":"128","author":"Chiron","year":"2016","journal-title":"Blood."},{"issue":"1","key":"2022090722225956600_B21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/PAS.0b013e3182a43996","article-title":"Assessment of SOX11 expression in routine lymphoma tissue sections: characterization of new monoclonal antibodies for diagnosis of mantle cell lymphoma","volume":"38","author":"Soldini","year":"2014","journal-title":"Am J Surg Pathol."},{"issue":"6","key":"2022090722225956600_B22","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/his.13857","article-title":"Clinicopathological evaluation of PD1\/PD-L1 axis in post-transplant lymphoproliferative disorders: association with EBV, PD-L1 Copy number alterations and outcome","volume":"75","author":"Veloza","year":"2019","journal-title":"Histopathology."},{"issue":"1","key":"2022090722225956600_B23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1182\/blood-2015-11-681460","article-title":"Pathogenic role of B-cell receptor signaling and canonical NF-\u03baB activation in mantle cell lymphoma","volume":"128","author":"Saba","year":"2016","journal-title":"Blood."},{"issue":"15","key":"2022090722225956600_B24","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1200\/JCO.2016.70.7901","article-title":"New molecular assay for the proliferation signature in mantle cell lymphoma applicable to formalin-fixed paraffin-embedded biopsies","volume":"35","author":"Scott","year":"2017","journal-title":"J Clin Oncol."},{"issue":"1","key":"2022090722225956600_B25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13045-017-0447-6","article-title":"Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma","volume":"10","author":"Balsas","year":"2017","journal-title":"J Hematol Oncol."},{"issue":"2","key":"2022090722225956600_B26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1365-2141.1999.01573.x","article-title":"Aberrant expression and reverse signalling of CD70 on malignant B cells","volume":"106","author":"Lens","year":"1999","journal-title":"Br J Haematol."},{"issue":"10","key":"2022090722225956600_B27","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3390\/cancers11101611","article-title":"Screening a broad range of solid and haematological tumour types for CD70 expression using a uniform IHC methodology as potential patient stratification method","volume":"11","author":"Flieswasser","year":"2019","journal-title":"Cancers (Basel)."},{"issue":"6","key":"2022090722225956600_B28","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.semcancer.2013.09.001","article-title":"B-cell receptor signaling as a driver of lymphoma development and evolution","volume":"23","author":"Niemann","year":"2013","journal-title":"Semin Cancer Biol."},{"issue":"3","key":"2022090722225956600_B29","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.4049\/jimmunol.180.3.1719","article-title":"Identification of Pax5 target genes in early B cell differentiation","volume":"180","author":"Pridans","year":"2008","journal-title":"J Immunol."},{"issue":"9","key":"2022090722225956600_B30","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1038\/leu.2014.84","article-title":"TGF-\u03b2 upregulates CD70 expression and induces exhaustion of effector memory T cells in B-cell non-Hodgkin\u2019s lymphoma","volume":"28","author":"Yang","year":"2014","journal-title":"Leukemia."},{"issue":"6-7","key":"2022090722225956600_B31","first-page":"332","article-title":"Significantly increased CD70 up regulation on TEL-AML positive B cell precursor acute lymphoblastic leukemia cells following CD40 stimulation","volume":"226","author":"Troeger","year":"2014","journal-title":"Klin Padiatr."},{"issue":"1","key":"2022090722225956600_B32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4049\/jimmunol.170.1.33","article-title":"Expression of the murine CD27 ligand CD70 in vitro and in vivo","volume":"170","author":"Tesselaar","year":"2003","journal-title":"J Immunol."},{"issue":"7","key":"2022090722225956600_B33","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1182\/blood-2007-03-082578","article-title":"CD70+ non-Hodgkin lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25 T cells","volume":"110","author":"Yang","year":"2007","journal-title":"Blood."},{"issue":"4","key":"2022090722225956600_B34","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1084\/jem.20112061","article-title":"Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway","volume":"210","author":"Coquet","year":"2013","journal-title":"J Exp Med."},{"issue":"2","key":"2022090722225956600_B35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/path.5361","article-title":"CD70 expression correlates with a worse prognosis in malignant pleural mesothelioma patients via immune evasion and enhanced invasiveness","volume":"250","author":"Inaguma","year":"2020","journal-title":"J Pathol."},{"issue":"4","key":"2022090722225956600_B36","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ijc.25429","article-title":"Regulatory T cells in tumor immunity","volume":"127","author":"Nishikawa","year":"2010","journal-title":"Int J Cancer."},{"issue":"5","key":"2022090722225956600_B37","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00109-015-1376-x","article-title":"Immunosuppressive cells in tumor immune escape and metastasis","volume":"94","author":"Liu","year":"2016","journal-title":"J Mol Med (Berl)."},{"issue":"20","key":"2022090722225956600_B38","doi-asserted-by":"crossref","first-page":"10145","DOI":"10.1158\/0008-5472.CAN-06-1822","article-title":"Attenuation of CD8(+) T-cell function by CD4(+)CD25(+) regulatory T cells in B-cell non-Hodgkin\u2019s lymphoma","volume":"66","author":"Yang","year":"2006","journal-title":"Cancer Res."},{"issue":"4","key":"2022090722225956600_B39","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nri1806","article-title":"Regulatory T cells, tumour immunity and immunotherapy","volume":"6","author":"Zou","year":"2006","journal-title":"Nat Rev Immunol."},{"issue":"7","key":"2022090722225956600_B40","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.ajpath.2017.02.017","article-title":"Numerous ontogenetic roads to mantle cell lymphoma: immunogenetic and immunohistochemical evidence","volume":"187","author":"Pouliou","year":"2017","journal-title":"Am J Pathol."},{"issue":"2","key":"2022090722225956600_B41","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1084\/jem.20152008","article-title":"CD70\/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia","volume":"214","author":"Riether","year":"2017","journal-title":"J Exp Med."},{"key":"2022090722225956600_B42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fonc.2018.00054","article-title":"Mechanisms of immune evasion and immune modulation by lymphoma cells","volume":"8","author":"Menter","year":"2018","journal-title":"Front Oncol."},{"issue":"7","key":"2022090722225956600_B43","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1074\/mcp.M800515-MCP200","article-title":"Protein profiling of plasma membranes defines aberrant signaling pathways in mantle cell lymphoma","volume":"8","author":"Boyd","year":"2009","journal-title":"Mol Cell Proteomics."},{"issue":"4","key":"2022090722225956600_B44","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1046\/j.1365-2141.2002.03931.x","article-title":"Investigatory and analytical approaches to differential gene expression profiling in mantle cell lymphoma","volume":"119","author":"Zhu","year":"2002","journal-title":"Br J Haematol."},{"issue":"7360","key":"2022090722225956600_B45","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10351","article-title":"Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma","volume":"476","author":"Morin","year":"2011","journal-title":"Nature."},{"issue":"9","key":"2022090722225956600_B46","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/ng.892","article-title":"Analysis of the coding genome of diffuse large B-cell lymphoma","volume":"43","author":"Pasqualucci","year":"2011","journal-title":"Nat Genet."},{"issue":"10","key":"2022090722225956600_B47","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1073\/pnas.1121343109","article-title":"Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing","volume":"109","author":"Lohr","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"issue":"5","key":"2022090722225956600_B48","doi-asserted-by":"crossref","first-page":"E830","DOI":"10.1002\/ijc.27416","article-title":"Recurrent deletions of the TNFSF7 and TNFSF9 genes in 19p13.3 in diffuse large B-cell and Burkitt lymphomas","volume":"131","author":"Scholtysik","year":"2012","journal-title":"Int J Cancer."},{"issue":"4","key":"2022090722225956600_B49","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1182\/blood.2019002699","article-title":"Distinct molecular profile of IRF4-rearranged large B-cell lymphoma","volume":"135","author":"Ramis-Zaldivar","year":"2020","journal-title":"Blood."},{"issue":"8","key":"2022090722225956600_B50","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/gcc.22072","article-title":"The costimulatory molecule CD70 is regulated by distinct molecular mechanisms and is associated with overall survival in diffuse large B-cell lymphoma","volume":"52","author":"Bertrand","year":"2013","journal-title":"Genes Chromosomes Cancer."},{"issue":"12","key":"2022090722225956600_B51","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1182\/blood.2020005289","article-title":"Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes","volume":"136","author":"Nadeu","year":"2020","journal-title":"Blood."},{"issue":"2","key":"2022090722225956600_B52","doi-asserted-by":"crossref","first-page":"710","DOI":"10.4049\/jimmunol.174.2.710","article-title":"Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells","volume":"174","author":"Bullock","year":"2005","journal-title":"J Immunol."},{"issue":"12","key":"2022090722225956600_B53","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1182\/blood.V85.12.3556.bloodjournal85123556","article-title":"Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells","volume":"85","author":"Ranheim","year":"1995","journal-title":"Blood."},{"key":"2022090722225956600_B54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2015.07.007","article-title":"CD70: an emerging target in cancer immunotherapy","volume":"155","author":"Jacobs","year":"2015","journal-title":"Pharmacol Ther."},{"issue":"8","key":"2022090722225956600_B55","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1084\/jem.20082492","article-title":"Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies","volume":"206","author":"Peggs","year":"2009","journal-title":"J Exp Med."},{"issue":"23","key":"2022090722225956600_B56","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1200\/JCO.2015.65.9789","article-title":"Nivolumab in patients with relapsed or refractory hematologic malignancy: preliminary results of a phase Ib study","volume":"34","author":"Lesokhin","year":"2016","journal-title":"J Clin Oncol."},{"issue":"21","key":"2022090722225956600_B57","doi-asserted-by":"crossref","first-page":"6411","DOI":"10.1158\/1078-0432.CCR-17-0613","article-title":"Phase I dose-escalation study of the anti-CD70 antibody ARGX-110 in advanced malignancies","volume":"23","author":"Aftimos","year":"2017","journal-title":"Clin Cancer Res."}],"updated-by":[{"DOI":"10.1182\/blood.2023021334","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000}}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/138\/22\/2202\/1919642\/bloodbld2020010527.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/138\/22\/2202\/1919642\/bloodbld2020010527.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T13:59:50Z","timestamp":1699192790000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/138\/22\/2202\/476270\/SOX11-CD70-and-Treg-cells-configure-the-tumor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,2]]},"references-count":57,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2021,12,2]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2020010527","relation":{"erratum":[{"id-type":"doi","id":"10.1182\/blood.2023021334","asserted-by":"object"}]},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,2]]}}}