{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:47:52Z","timestamp":1788346072496,"version":"build-2803163510"},"reference-count":53,"publisher":"American Society of Hematology","issue":"18","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent studies have shown that maternal anti-CD36 antibodies represent a frequent cause of fetal\/neonatal alloimmune thrombocytopenia (FNAIT) in Asian and African populations. However, little is known about the pathomechanism and antenatal treatment of anti-CD36\u2013mediated FNAIT. Here, we established a novel animal model to examine the clinical features of pups from immunized Cd36\u2212\/\u2212 female mice after breeding with wild-type male mice. Mild thrombocytopenia was observed, but high pup mortality was also documented (40.26%). Administration of intravenous immunoglobulin (IVIG) (1 g\/kg) on days 7, 12, and 17 to immunized Cd36\u2212\/\u2212 mothers after breeding reduced fetal death (12.70%). However, delaying the IVIG administration series on days 10, 15, and 20 did not reduce fetal death (40.00%). In contrast, injection of deglycosylated anti-CD36 (deg-anti-CD36) polyclonal antibodies (5 mg\/kg) on days 10, 15, and 20 significantly reduced fetal death (5.26%). Subsequently, monoclonal antibodies (mAbs) against mouse CD36 were developed, and one clone producing high-affinity anti-CD36 (termed 32-106) effectively inhibited maternal antibody binding and was therefore selected. Using the same approach of deg-anti-CD36, the administration of deg-32-106 significantly reduced fetal death (2.17%). Furthermore, immunized Cd36\u2212\/\u2212 mothers exhibited placental deficiency. Accordingly, maternal anti-CD36 antibodies inhibited angiogenesis of placenta endothelial cells, which could be restored by deg-32-106. In summary, maternal anti-CD36 antibodies caused a high frequency of fetal death in our animal model, associated with placental dysfunction. This deleterious effect could be diminished by the antenatal administration of IVIG and deg-mAb 32-106. Interestingly, treatment with deg-32-106 seems more beneficial considering the lower dose, later start of treatment, and therapy success.<\/jats:p>","DOI":"10.1182\/blood.2021011131","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T03:53:30Z","timestamp":1622087610000},"page":"1757-1767","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":23,"title":["Successful prenatal therapy for anti-CD36-mediated severe FNAIT by deglycosylated antibodies in a novel murine model"],"prefix":"10.1182","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1328-6920","authenticated-orcid":false,"given":"Xiuzhang","family":"Xu","sequence":"first","affiliation":[{"name":"Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, Guangdong, China;"},{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, Guangdong, China;"},{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ye","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Xia","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaori","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangkai","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Shao","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0532-2119","authenticated-orcid":false,"given":"Haoqiang","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyu","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology, LKSKI-Keenan Research Centre, St. Michael\u2019s Hospital, University of Toronto, Toronto, ON, Canada;"},{"name":"Canadian Blood Services Centre for Innovation, Toronto, ON, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongshui","family":"Fu","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, Guangdong, China;"},{"name":"Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, China; and"},{"name":"Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6943-3945","authenticated-orcid":false,"given":"Sentot","family":"Santoso","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion, Guangzhou Blood Centre, Guangzhou, Guangdong, China;"},{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"11","key":"2021110415300672700_B1","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1182\/blood-2016-10-739656","article-title":"Antenatal management in fetal and neonatal alloimmune 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be prevented by intravenous IgG and anti-FcRn therapies","volume":"121","author":"Li","year":"2011","journal-title":"J Clin Invest."},{"issue":"8","key":"2021110415300672700_B32","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1161\/ATVBAHA.114.303315","article-title":"Factor XII regulates the pathological process of thrombus formation on ruptured plaques","volume":"34","author":"Kuijpers","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"12","key":"2021110415300672700_B33","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1074\/mcp.M114.038513","article-title":"Copy number analysis of the murine platelet proteome spanning the complete abundance range","volume":"13","author":"Zeiler","year":"2014","journal-title":"Mol Cell Proteomics."},{"issue":"3","key":"2021110415300672700_B34","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1046\/j.1537-2995.2001.41030375.x","article-title":"Neonatal alloimmune thrombocytopenia due to 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