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Although numbers lavaged from both genotypes were virtually identical, there were marked differences in maturation: newly recruited WT MoMacs rapidly enlarged and matured, losing Ly6C and gaining MHCII, CD206, and CD36, whereas CGD MoMacs remained small and were mostly Ly6C+MHCII\u2013. RNA-sequencing analyses showed few intrinsic differences between genotypes in newly recruited MoMacs but significant differences with time. WT MoMacs displayed changes in metabolism, adhesion, and reparative functions, whereas CGD MoMacs remained inflammatory. PKH dye labeling revealed that although WT MoMacs were mostly recruited within the first 24 hours and remained in the peritoneum while maturing and enlarging, CGD monocytes streamed into the peritoneum for days, with many migrating to the diaphragm where they were found in fibrin(ogen) clots surrounding clusters of neutrophils in nascent pyogranulomata. Importantly, these observations seemed to be driven by milieu: adoptive transfer of CGD MoMacs into inflamed peritonea of WT mice resulted in immunophenotypic maturation and normal behavior, whereas altered maturation\/behavior of WT MoMacs resulted from transfer into inflamed peritonea of CGD mice. In addition, Nox2-deficient MoMacs behaved similarly to their Nox2-sufficient counterparts within the largely WT milieu of mixed bone marrow chimeras. These data show persistent recruitment with fundamental failure of MoMac maturation in CGD.<\/jats:p>","DOI":"10.1182\/blood.2021011798","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T19:04:39Z","timestamp":1635275079000},"page":"1707-1721","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":10,"title":["Heightened turnover and failed maturation of monocyte-derived macrophages in murine chronic granulomatous disease"],"prefix":"10.1182","volume":"139","author":[{"given":"Sophie L.","family":"Gibbings","sequence":"first","affiliation":[{"name":"Department of Pediatrics, National Jewish Health, Denver, CO;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5464-0295","authenticated-orcid":false,"given":"Kelsey C.","family":"Haist","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Jewish Health, Denver, CO;"},{"name":"Department of Immunology\/Microbiology, University of Colorado Denver, Aurora, CO;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Nick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Jewish Health, Denver, CO;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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