{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:44:12Z","timestamp":1793317452375,"version":"4.5.0"},"reference-count":20,"publisher":"American Society of Hematology","issue":"2","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Posttreatment evaluation of gastric mucosa-associated lymphoid tissue (MALT) lymphoma currently relies on esophagogastroduodenoscopy with histological assessment of biopsies. Overexpression of the G protein\u2013coupled C-X-C chemokine receptor type 4 (CXCR4) has been previously observed in MALT lymphoma. The aim of this prospective study was to evaluate positron emission tomography (PET) with the novel CXCR4 tracer [68Ga]Pentixafor as a potential alternative to follow up biopsies for assessment of residual disease (noncomplete remission [CR]) after first-line Helicobacter pylori eradication. Forty-six post\u2013H pylori eradication [68Ga]Pentixafor\u2013PET\/magnetic resonance imaging (MRI) examinations of 26 gastric MALT lymphoma patients, and 20 [68Ga]Pentixafor\u2013PET\/MRI examinations of 20 control group patients without lymphoma, were analyzed. In the MALT lymphoma group, time-matched gastric biopsies were used as reference standard and showed CR in 6 cases. Pooled examination-based accuracy, sensitivity, specificity, and positive and negative predictive values of [68Ga]Pentixafor\u2013PET for detection of residual gastric MALT lymphoma at follow-up were 97.0%, 95.0%, 100.0%, 100.0%, and 92.9%, respectively. Maximum and mean PET standardized uptake values showed moderate correlation with immunohistochemistry-based CXCR4+ cell counts, with correlation coefficients of r = 0.51 and r = 0.52 (P = .008 and P = .006). In summary, CXCR4 imaging with [68Ga]Pentixafor\u2013PET may represent a promising test for assessment of residual gastric MALT lymphomas after H pylori eradication.<\/jats:p>","DOI":"10.1182\/blood.2021013239","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T14:00:07Z","timestamp":1631714407000},"page":"240-244","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":46,"title":["CXCR4 PET\/MRI for follow-up of gastric mucosa\u2013associated lymphoid tissue lymphoma after first-line\n                    <i>Helicobacter\u00a0pylori<\/i>\n                    eradication"],"prefix":"10.1182","volume":"139","author":[{"given":"Marius E.","family":"Mayerhoefer","sequence":"first","affiliation":[{"name":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY;"},{"name":"Division of General and Pediatric Radiology, Department of Biomedical Imaging and Image-guided 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Medicine I,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Rohrbeck","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical University of Vienna, Vienna, Austria; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Simonitsch-Klupp","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical University of Vienna, Vienna, Austria; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4222-4083","authenticated-orcid":false,"given":"Marcus","family":"Hacker","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Leisser","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, 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