{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:30:05Z","timestamp":1793212205802,"version":"4.5.0"},"reference-count":65,"publisher":"American Society of Hematology","issue":"9","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute lung injury, referred to as the acute chest syndrome, is a major cause of morbidity and mortality in patients with sickle cell disease (SCD), which often occurs in the setting of a vaso-occlusive painful crisis. P-selectin antibody therapy reduces hospitalization of patients with SCD by \u223c50%, suggesting that an unknown P-selectin\u2013independent mechanism promotes remaining vaso-occlusive events. In patients with SCD, intraerythrocytic polymerization of mutant hemoglobin promotes ischemia-reperfusion injury and hemolysis, which leads to the development of sterile inflammation. Using intravital microscopy in transgenic, humanized mice with SCD and in\u00a0vitro studies with blood from patients with SCD, we reveal for the first time that the sterile inflammatory milieu in SCD promotes caspase-4\/11\u2013dependent activation of neutrophil\u2013gasdermin D (GSDMD), which triggers P-selectin\u2013independent shedding of neutrophil extracellular traps (NETs) in the liver. Remarkably, these NETs travel intravascularly from liver to lung, where they promote neutrophil-platelet aggregation and the development of acute lung injury. This study introduces a novel paradigm that liver-to-lung embolic translocation of NETs promotes pulmonary vascular vaso-occlusion and identifies a new GSDMD-mediated, P-selectin\u2013independent mechanism of lung injury in\u00a0SCD.<\/jats:p>","DOI":"10.1182\/blood.2021014552","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T15:52:52Z","timestamp":1655999572000},"page":"1020-1037","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":68,"title":["Liver-to-lung microembolic NETs promote gasdermin D\u2013dependent inflammatory lung injury in sickle cell disease"],"prefix":"10.1182","volume":"140","author":[{"given":"Ravi","family":"Vats","sequence":"first","affiliation":[{"name":"1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA;"},{"name":"2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz W.","family":"Kaminski","sequence":"additional","affiliation":[{"name":"1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Brzoska","sequence":"additional","affiliation":[{"name":"1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA;"},{"name":"3Division of Hematology and Oncology,"},{"name":"4Sickle Cell Center of Excellence, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4685-1954","authenticated-orcid":false,"given":"John A.","family":"Leech","sequence":"additional","affiliation":[{"name":"1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egemen","family":"Tutuncuoglu","sequence":"additional","affiliation":[{"name":"1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omika","family":"Katoch","sequence":"additional","affiliation":[{"name":"1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jude","family":"Jonassaint","sequence":"additional","affiliation":[{"name":"1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA;"},{"name":"3Division of Hematology and Oncology,"},{"name":"4Sickle Cell Center of Excellence, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3245-9978","authenticated-orcid":false,"given":"Jesus","family":"Tejero","sequence":"additional","affiliation":[{"name":"1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA;"},{"name":"2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA; and"},{"name":"5Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico M.","family":"Novelli","sequence":"additional","affiliation":[{"name":"1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA;"},{"name":"3Division of Hematology and Oncology,"},{"name":"4Sickle Cell Center of Excellence, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8763-4844","authenticated-orcid":false,"given":"Tirthadipa","family":"Pradhan-Sundd","sequence":"additional","affiliation":[{"name":"1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA;"},{"name":"3Division of Hematology and Oncology,"},{"name":"4Sickle Cell Center of Excellence, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Gladwin","sequence":"additional","affiliation":[{"name":"1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA;"},{"name":"4Sickle Cell Center of Excellence, and"},{"name":"5Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7568-5719","authenticated-orcid":false,"given":"Prithu","family":"Sundd","sequence":"additional","affiliation":[{"name":"1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA;"},{"name":"2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA; and"},{"name":"4Sickle Cell Center of Excellence, and"},{"name":"5Division of Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"9757","key":"2022090115232776100_B1","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(10)61029-X","article-title":"Sickle-cell disease","volume":"376","author":"Rees","year":"2010","journal-title":"Lancet."},{"issue":"9963","key":"2022090115232776100_B2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"385","author":"Abubakar","year":"2015","journal-title":"Lancet."},{"issue":"1","key":"2022090115232776100_B3","doi-asserted-by":"crossref","first-page":"18010","DOI":"10.1038\/nrdp.2018.10","article-title":"Sickle cell disease","volume":"4","author":"Kato","year":"2018","journal-title":"Nat Rev Dis Primers."},{"key":"2022090115232776100_B4","first-page":"93","volume-title":"Sickle Cell Disease.","author":"Sundd","year":"2021"},{"issue":"1","key":"2022090115232776100_B5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-pathmechdis-012418-012838","article-title":"Pathophysiology of sickle cell disease","volume":"14","author":"Sundd","year":"2019","journal-title":"Annu Rev Pathol."},{"issue":"2","key":"2022090115232776100_B6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41573-018-0003-2","article-title":"Therapeutic strategies for sickle cell disease: towards a multi-agent approach","volume":"18","author":"Telen","year":"2019","journal-title":"Nat Rev Drug Discov."},{"issue":"7570","key":"2022090115232776100_B7","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature15367","article-title":"Neutrophil ageing is regulated by the microbiome","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature."},{"issue":"4","key":"2022090115232776100_B8","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nm.1939","article-title":"Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury","volume":"15","author":"Hidalgo","year":"2009","journal-title":"Nat Med."},{"issue":"25","key":"2022090115232776100_B9","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1056\/NEJM200006223422502","article-title":"Causes and outcomes of the acute chest syndrome in sickle cell disease","volume":"342","author":"Vichinsky","year":"2000","journal-title":"N Engl J Med."},{"issue":"11","key":"2022090115232776100_B10","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1164\/rccm.201111-2082CI","article-title":"Pulmonary complications of sickle cell disease","volume":"185","author":"Miller","year":"2012","journal-title":"Am J Respir Crit Care Med."},{"issue":"2","key":"2022090115232776100_B11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/ajh.24224","article-title":"Pulmonary platelet thrombi and vascular pathology in acute chest syndrome in patients with sickle cell disease","volume":"91","author":"Anea","year":"2016","journal-title":"Am J Hematol."},{"issue":"9","key":"2022090115232776100_B12","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1164\/rccm.201105-0783OC","article-title":"Pulmonary artery thrombosis during acute chest syndrome in sickle cell disease","volume":"184","author":"Mekontso Dessap","year":"2011","journal-title":"Am J Respir Crit Care Med."},{"issue":"1","key":"2022090115232776100_B13","doi-asserted-by":"crossref","first-page":"e89761","DOI":"10.1172\/jci.insight.89761","article-title":"Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli","volume":"2","author":"Bennewitz","year":"2017","journal-title":"JCI Insight."},{"issue":"1","key":"2022090115232776100_B14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1164\/rccm.201807-1370OC","article-title":"Platelet extracellular vesicles drive inflammasome-IL-1\u03b2-dependent lung injury in sickle cell disease","volume":"201","author":"Vats","year":"2020","journal-title":"Am J Respir Crit Care Med."},{"issue":"5","key":"2022090115232776100_B15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1056\/NEJMoa1611770","article-title":"Crizanlizumab for the prevention of pain crises in sickle cell disease","volume":"376","author":"Ataga","year":"2017","journal-title":"N Engl J Med."},{"issue":"24","key":"2022090115232776100_B16","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1182\/blood-2014-03-563874","article-title":"Erythroid DAMPs drive inflammation in SCD","volume":"123","author":"Gladwin","year":"2014","journal-title":"Blood."},{"issue":"3","key":"2022090115232776100_B17","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1172\/JCI89741","article-title":"Intravascular hemolysis and the pathophysiology of sickle cell disease","volume":"127","author":"Kato","year":"2017","journal-title":"J Clin Invest."},{"issue":"24","key":"2022090115232776100_B18","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1182\/blood-2013-10-529982","article-title":"Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease","volume":"123","author":"Chen","year":"2014","journal-title":"Blood."},{"issue":"3","key":"2022090115232776100_B19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nm.4294","article-title":"An emerging role for neutrophil extracellular traps in noninfectious disease","volume":"23","author":"Jorch","year":"2017","journal-title":"Nat Med."},{"issue":"3","key":"2022090115232776100_B20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41418-018-0261-x","article-title":"To NET or not to NET: current opinions and state of the science regarding the formation of neutrophil extracellular traps","volume":"26","author":"Boeltz","year":"2019","journal-title":"Cell Death Differ."},{"issue":"5663","key":"2022090115232776100_B21","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science."},{"key":"2022090115232776100_B22","doi-asserted-by":"crossref","first-page":"102109","DOI":"10.1016\/j.redox.2021.102109","article-title":"The many roles of myeloperoxidase: from inflammation and immunity to biomarkers, drug metabolism and drug discovery","volume":"46","author":"Siraki","year":"2021","journal-title":"Redox Biol."},{"issue":"11","key":"2022090115232776100_B23","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.3324\/haematol.2013.088021","article-title":"Nucleosomes and neutrophil activation in sickle cell disease painful crisis","volume":"98","author":"Schimmel","year":"2013","journal-title":"Haematologica."},{"issue":"7","key":"2022090115232776100_B24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat Rev Immunol."},{"issue":"26","key":"2022090115232776100_B25","doi-asserted-by":"crossref","first-page":"eaar6676","DOI":"10.1126\/sciimmunol.aar6676","article-title":"Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps","volume":"3","author":"Chen","year":"2018","journal-title":"Sci Immunol."},{"issue":"26","key":"2022090115232776100_B26","doi-asserted-by":"crossref","first-page":"eaar6689","DOI":"10.1126\/sciimmunol.aar6689","article-title":"Gasdermin D plays a vital role in the generation of neutrophil extracellular traps","volume":"3","author":"Sollberger","year":"2018","journal-title":"Sci Immunol."},{"issue":"19","key":"2022090115232776100_B27","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1182\/blood.2020009779","article-title":"P-selectin deficiency promotes liver senescence in sickle cell disease mice","volume":"137","author":"Vats","year":"2021","journal-title":"Blood."},{"key":"2022090115232776100_B28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exphem.2020.03.002","article-title":"Tandem P-selectin glycoprotein ligand immunoglobulin prevents lung vaso-occlusion in sickle cell disease mice","volume":"84","author":"Vats","year":"2020","journal-title":"Exp Hematol."},{"issue":"6","key":"2022090115232776100_B29","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1002\/hep.31239","article-title":"Impaired bile secretion promotes hepatobiliary injury in sickle cell disease","volume":"72","author":"Vats","year":"2020","journal-title":"Hepatology."},{"issue":"11","key":"2022090115232776100_B30","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1172\/JCI64578","article-title":"Extracellular hemin crisis triggers acute chest syndrome in sickle mice","volume":"123","author":"Ghosh","year":"2013","journal-title":"J Clin Invest."},{"issue":"3","key":"2022090115232776100_B31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1182\/blood-2013-04-495887","article-title":"Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease","volume":"123","author":"Belcher","year":"2014","journal-title":"Blood."},{"issue":"4","key":"2022090115232776100_B32","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1182\/blood-2006-02-004812","article-title":"Correction of sickle cell disease by homologous recombination in embryonic stem cells","volume":"108","author":"Wu","year":"2006","journal-title":"Blood."},{"issue":"2","key":"2022090115232776100_B33","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1182\/bloodadvances.2019000603","article-title":"P-selectin-deficient mice to study pathophysiology of sickle cell disease [published correction appears in Blood Adv. 2020;4(5):803]","volume":"4","author":"Bennewitz","year":"2020","journal-title":"Blood Adv."},{"issue":"7575","key":"2022090115232776100_B34","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature."},{"issue":"2","key":"2022090115232776100_B35","doi-asserted-by":"crossref","first-page":"e29748","DOI":"10.4161\/intv.29748","article-title":"Quantitative intravital two-photon excitation microscopy reveals absence of pulmonary vaso-occlusion in unchallenged sickle cell disease mice","volume":"3","author":"Bennewitz","year":"2014","journal-title":"Intravital."},{"issue":"26","key":"2022090115232776100_B36","doi-asserted-by":"crossref","first-page":"eaat2738","DOI":"10.1126\/sciimmunol.aat2738","article-title":"Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis","volume":"3","author":"Rathkey","year":"2018","journal-title":"Sci Immunol."},{"issue":"7","key":"2022090115232776100_B37","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","article-title":"FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation","volume":"21","author":"Hu","year":"2020","journal-title":"Nat Immunol."},{"issue":"1","key":"2022090115232776100_B38","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1002\/cpcy.80","article-title":"Live imaging of the lung","volume":"95","author":"Brzoska","year":"2020","journal-title":"Curr Protoc Cytom."},{"issue":"1","key":"2022090115232776100_B39","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.1038\/ncomms7673","article-title":"Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature","volume":"6","author":"Kolaczkowska","year":"2015","journal-title":"Nat Commun."},{"issue":"4","key":"2022090115232776100_B40","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1053\/j.gastro.2018.06.048","article-title":"Dysregulated bile transporters and impaired tight junctions during chronic liver injury in mice","volume":"155","author":"Pradhan-Sundd","year":"2018","journal-title":"Gastroenterology."},{"key":"2022090115232776100_B41","doi-asserted-by":"crossref","first-page":"3.20.2","DOI":"10.1002\/0471142735.im0320s110","article-title":"Isolation of mouse neutrophils","volume":"110","author":"Swamydas","year":"2015","journal-title":"Curr Protoc Immunol."},{"issue":"10","key":"2022090115232776100_B42","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nmeth.1508","article-title":"Quantitative dynamic footprinting microscopy reveals mechanisms of neutrophil rolling","volume":"7","author":"Sundd","year":"2010","journal-title":"Nat Methods."},{"issue":"7411","key":"2022090115232776100_B43","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature11248","article-title":"\u2018Slings\u2019 enable neutrophil rolling at high shear","volume":"488","author":"Sundd","year":"2012","journal-title":"Nature."},{"issue":"17","key":"2022090115232776100_B44","first-page":"745","article-title":"Neutrophil isolation protocol","author":"Oh","year":"2008","journal-title":"J Vis Exp."},{"issue":"20","key":"2022090115232776100_B45","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1182\/blood.2019003543","article-title":"Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease","volume":"135","author":"Sparkenbaugh","year":"2020","journal-title":"Blood."},{"key":"2022090115232776100_B46","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.3389\/fimmu.2019.02957","article-title":"Citrullinated histone H3 as a therapeutic target for endotoxic shock in mice","volume":"10","author":"Deng","year":"2020","journal-title":"Front Immunol."},{"issue":"20","key":"2022090115232776100_B47","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1182\/blood-2018-10-862243","article-title":"Neutrophils: back in the thrombosis spotlight","volume":"133","author":"Noubouossie","year":"2019","journal-title":"Blood."},{"issue":"40","key":"2022090115232776100_B48","doi-asserted-by":"crossref","first-page":"eaaw0336","DOI":"10.1126\/sciimmunol.aaw0336","article-title":"Neutrophil extracellular traps drive inflammatory pathogenesis in malaria","volume":"4","author":"Knackstedt","year":"2019","journal-title":"Sci Immunol."},{"issue":"4","key":"2022090115232776100_B49","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat Med."},{"issue":"8","key":"2022090115232776100_B50","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nm.4146","article-title":"On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver","volume":"22","author":"Theurl","year":"2016","journal-title":"Nat Med."},{"issue":"7","key":"2022090115232776100_B51","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1182\/blood.2019000172","article-title":"Patrolling monocytes scavenge endothelial-adherent sickle RBCs: a novel mechanism of inhibition of vaso-occlusion in SCD","volume":"134","author":"Liu","year":"2019","journal-title":"Blood."},{"issue":"1","key":"2022090115232776100_B52","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-stimulated genes: a complex web of host defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu Rev Immunol."},{"issue":"4","key":"2022090115232776100_B53","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nrrheum.2018.31","article-title":"Type I interferon in rheumatic diseases","volume":"14","author":"Muskardin","year":"2018","journal-title":"Nat Rev Rheumatol."},{"issue":"12","key":"2022090115232776100_B54","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.3324\/haematol.2019.238295","article-title":"The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway","volume":"105","author":"Hermand","year":"2020","journal-title":"Haematologica."},{"issue":"13","key":"2022090115232776100_B55","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1182\/blood.2021011629","article-title":"Type I interferon is induced by hemolysis and drives antibody-mediated erythrophagocytosis in sickle cell disease","volume":"138","author":"Liu","year":"2021","journal-title":"Blood."},{"issue":"10","key":"2022090115232776100_B56","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.3324\/haematol.2021.278573","article-title":"Low incidence of COVID-19 severe complications in a large cohort of children with sickle cell disease: a protective role for basal interferon-1 activation?","volume":"106","author":"Brousse","year":"2021","journal-title":"Haematologica."},{"issue":"5","key":"2022090115232776100_B57","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41590-019-0368-3","article-title":"Innate immunity to intracellular LPS","volume":"20","author":"Rathinam","year":"2019","journal-title":"Nat Immunol."},{"issue":"1","key":"2022090115232776100_B58","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nri.2015.7","article-title":"Converging roles of caspases in inflammasome activation, cell death and innate immunity","volume":"16","author":"Man","year":"2016","journal-title":"Nat Rev Immunol."},{"issue":"3","key":"2022090115232776100_B59","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cell.2012.07.007","article-title":"TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria","volume":"150","author":"Rathinam","year":"2012","journal-title":"Cell."},{"issue":"582","key":"2022090115232776100_B60","doi-asserted-by":"crossref","first-page":"eaax4917","DOI":"10.1126\/scisignal.aax4917","article-title":"IRF2 transcriptionally induces GSDMD expression for pyroptosis","volume":"12","author":"Kayagaki","year":"2019","journal-title":"Sci Signal."},{"issue":"8","key":"2022090115232776100_B61","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.4049\/jimmunol.2000226","article-title":"Noncanonical roles of caspase-4 and caspase-5 in heme-driven IL-1\u03b2 release and cell death","volume":"206","author":"Bol\u00edvar","year":"2021","journal-title":"J Immunol."},{"issue":"1","key":"2022090115232776100_B62","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.immuni.2019.05.005","article-title":"Inflammasome regulates hematopoiesis through cleavage of the master erythroid transcription factor GATA1","volume":"51","author":"Tyrkalska","year":"2019","journal-title":"Immunity."},{"issue":"11","key":"2022090115232776100_B63","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1016\/j.celrep.2018.02.067","article-title":"Gasdermin D exerts anti-inflammatory effects by promoting neutrophil death","volume":"22","author":"Kambara","year":"2018","journal-title":"Cell Rep."},{"issue":"1","key":"2022090115232776100_B64","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1038\/s41467-020-16043-9","article-title":"N-GSDMD trafficking to neutrophil organelles facilitates IL-1\u03b2 release independently of plasma membrane pores and pyroptosis","volume":"11","author":"Karmakar","year":"2020","journal-title":"Nat Commun."},{"issue":"6","key":"2022090115232776100_B65","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1056\/NEJMoa1903212","article-title":"A phase 3 randomized trial of voxelotor in sickle cell disease","volume":"381","author":"Vichinsky","year":"2019","journal-title":"N Engl J Med."}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/140\/9\/1020\/1917760\/bloodbld2021014552.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/140\/9\/1020\/1917760\/bloodbld2021014552.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T12:22:13Z","timestamp":1700742133000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/140\/9\/1020\/485689\/Liver-to-lung-microembolic-NETs-promote-gasdermin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":65,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,1]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2021014552","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742204329.793594250","asserted-by":"object"}]},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,1]]}}}