{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:23:24Z","timestamp":1785450204034,"version":"3.56.0"},"reference-count":75,"publisher":"American Society of Hematology","issue":"17","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/legalcode"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Both innate and adaptive lymphocytes have critical roles in mucosal defense that contain commensal microbial communities and protect against pathogen invasion. Here we characterize mucosal immunity in patients with severe combined immunodeficiency (SCID) receiving hematopoietic stem cell transplantation (HSCT) with or without myeloablation. We confirmed that pretransplant conditioning had an impact on innate (natural killer and innate lymphoid cells) and adaptive (B and T cells) lymphocyte reconstitution in these patients with SCID and now show that this further extends to generation of T helper 2 and type 2 cytotoxic T cells. Using an integrated approach to assess nasopharyngeal immunity, we identified a local mucosal defect in type 2 cytokines, mucus production, and a selective local immunoglobulin A (IgA) deficiency in HSCT-treated SCID patients with genetic defects in IL2RG\/GC or JAK3. These patients have a reduction in IgA-coated nasopharyngeal bacteria and exhibit microbial dysbiosis with increased pathobiont carriage. Interestingly, intravenous immunoglobulin replacement therapy can partially normalize nasopharyngeal immunoglobulin profiles and restore microbial communities in GC\/JAK3 patients. Together, our results suggest a potential nonredundant role for type 2\u00a0immunity and\/or of local IgA antibody production in the maintenance of nasopharyngeal microbial homeostasis and mucosal barrier function.<\/jats:p>","DOI":"10.1182\/blood.2021014654","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T22:46:20Z","timestamp":1644878780000},"page":"2585-2600","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":10,"title":["Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC-transplanted SCID patients with IL2RG\/JAK3 deficiency"],"prefix":"10.1182","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-1152","authenticated-orcid":false,"given":"Pedro","family":"Goncalves","sequence":"first","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris Cit\u00e9, Inserm U1223, Innate Immunity Unit, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6714-1308","authenticated-orcid":false,"given":"Jean-Marc","family":"Doisne","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris Cit\u00e9, Inserm U1223, Innate Immunity Unit, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6233-6966","authenticated-orcid":false,"given":"Toshiki","family":"Eri","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris Cit\u00e9, Inserm U1223, Innate Immunity Unit, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5478-482X","authenticated-orcid":false,"given":"Bruno","family":"Charbit","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris Cit\u00e9, Center for Translational Science, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-0984","authenticated-orcid":false,"given":"Vincent","family":"Bondet","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris Cit\u00e9, Translational Immunology Unit, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4182-6442","authenticated-orcid":false,"given":"Celine","family":"Posseme","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris Cit\u00e9, Translational Immunology Unit, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Llibre","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris Cit\u00e9, Translational Immunology Unit, Paris, 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