{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:19:22Z","timestamp":1774624762821,"version":"3.50.1"},"reference-count":65,"publisher":"American Society of Hematology","issue":"26","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Myeloid-derived suppressor cells (MDSCs) are heterogeneous immature cells and natural inhibitors of adaptive immunity. Metabolic fitness of MDSCs is fundamental for its suppressive activity toward effector T cells. Our previous studies showed that the number and inhibitory function of MDSCs were impaired in patients with immune thrombocytopenia (ITP) compared with healthy controls. In this study, we analyzed the effects of decitabine on MDSCs from patients with ITP, both in\u00a0vitro and in\u00a0vivo. We found that low-dose decitabine promoted the generation of MDSCs and enhanced their aerobic metabolism and immunosuppressive functions. Lower expression of liver kinase 1 (LKB1) was found in MDSCs from patients with ITP, which was corrected by decitabine therapy. LKB1 short hairpin RNA (shRNA) transfection effectively blocked the function of MDSCs and almost offset the enhanced effect of decitabine on impaired MDSCs. Subsequently, anti-CD61 immune-sensitized splenocytes were transferred into severe combined immunodeficient (SCID) mice to induce ITP in murine models. Passive transfer of decitabine-modulated MDSCs significantly raised platelet counts compared with that of phosphate buffered saline\u2013modulated MDSCs. However, when LKB1 shRNA-transfected MDSCs were transferred into SCID mice, the therapeutic effect of decitabine in alleviating thrombocytopenia was quenched. In conclusion, our study suggests that the impaired aerobic metabolism of MDSCs is involved in the pathogenesis of ITP, and the modulatory effect of decitabine on MDSC metabolism contributes to the improvement of its immunosuppressive function. This provides a possible mechanism for sustained remission elicited by low-dose decitabine in patients with ITP.<\/jats:p>","DOI":"10.1182\/blood.2022016029","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T19:53:37Z","timestamp":1661802817000},"page":"2818-2834","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":20,"title":["Low-dose decitabine modulates myeloid-derived suppressor cell fitness via LKB1 in immune thrombocytopenia"],"prefix":"10.1182","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1496-1553","authenticated-orcid":false,"given":"Xiaofei","family":"Ni","sequence":"first","affiliation":[{"name":"1Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2465-5944","authenticated-orcid":false,"given":"Lingjun","family":"Wang","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyi","family":"Wang","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianshu","family":"Yu","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xie","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"2Department of Hematology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guosheng","family":"Li","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7376-726X","authenticated-orcid":false,"given":"Hai","family":"Zhou","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2981-9533","authenticated-orcid":false,"given":"Miao","family":"Xu","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-0483","authenticated-orcid":false,"given":"Ming","family":"Hou","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"3Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"4Leading Research Group of Scientific Innovation, Department of Science and Technology of Shandong Province, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1434-1490","authenticated-orcid":false,"given":"Jun","family":"Peng","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"3Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1403-1882","authenticated-orcid":false,"given":"Yu","family":"Hou","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"3Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"234","reference":[{"issue":"26","key":"2022122916265098700_bib1","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1182\/blood-2009-01-129155","article-title":"The ITP syndrome: pathogenic and clinical diversity","volume":"113","author":"Cines","year":"2009","journal-title":"Blood"},{"issue":"9","key":"2022122916265098700_bib2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/nm921","article-title":"T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura","volume":"9","author":"Olsson","year":"2003","journal-title":"Nat Med"},{"issue":"10","key":"2022122916265098700_bib3","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1056\/NEJMcp1810479","article-title":"Immune thrombocytopenia","volume":"381","author":"Cooper","year":"2019","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"2022122916265098700_bib4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/MOH.0000000000000447","article-title":"Pathophysiology of immune thrombocytopenia","volume":"25","author":"Li","year":"2018","journal-title":"Curr Opin Hematol"},{"issue":"22","key":"2022122916265098700_bib5","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1182\/bloodadvances.2019000812","article-title":"Updated international consensus report\u00a0on\u00a0the investigation and management\u00a0of primary immune thrombocytopenia","volume":"3","author":"Provan","year":"2019","journal-title":"Blood Adv"},{"issue":"2","key":"2022122916265098700_bib6","first-page":"16","article-title":"Pathogenesis and therapeutic mechanisms in immune thrombocytopenia (ITP)","volume":"6","author":"Zufferey","year":"2017","journal-title":"J\u00a0Clin Med"},{"issue":"21","key":"2022122916265098700_bib7","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1182\/blood-2017-03-754119","article-title":"Clinical updates in adult immune thrombocytopenia","volume":"129","author":"Lambert","year":"2017","journal-title":"Blood"},{"issue":"6","key":"2022122916265098700_bib8","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/MOH.0000000000000612","article-title":"An update on the pathophysiology of immune thrombocytopenia","volume":"27","author":"Semple","year":"2020","journal-title":"Curr Opin Hematol"},{"issue":"1","key":"2022122916265098700_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/2326-6066.CIR-16-0297","article-title":"Myeloid-derived suppressor cells","volume":"5","author":"Gabrilovich","year":"2017","journal-title":"Cancer Immunol Res"},{"issue":"2","key":"2022122916265098700_bib10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41590-017-0022-x","article-title":"Myeloid-derived suppressor cells coming of age","volume":"19","author":"Veglia","year":"2018","journal-title":"Nat Immunol"},{"issue":"1","key":"2022122916265098700_bib11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4049\/jimmunol.1300654","article-title":"Reciprocal relationship between myeloid-derived suppressor cells and T cells","volume":"191","author":"Nagaraj","year":"2013","journal-title":"J\u00a0Immunol"},{"issue":"11","key":"2022122916265098700_bib12","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1158\/2326-6066.CIR-15-0036","article-title":"Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies","volume":"3","author":"Hossain","year":"2015","journal-title":"Cancer immunology research"},{"issue":"10","key":"2022122916265098700_bib13","doi-asserted-by":"crossref","first-page":"e1344804","DOI":"10.1080\/2162402X.2017.1344804","article-title":"Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells","volume":"6","author":"Al-Khami","year":"2017","journal-title":"Oncoimmunology"},{"issue":"12","key":"2022122916265098700_bib14","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1182\/blood-2015-10-674531","article-title":"High-dose dexamethasone corrects impaired myeloid-derived suppressor cell function via Ets1 in immune thrombocytopenia","volume":"127","author":"Hou","year":"2016","journal-title":"Blood"},{"issue":"4","key":"2022122916265098700_bib15","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1182\/blood-2005-12-015222","article-title":"Therapy with high-dose dexamethasone (HD-DXM) in previously untreated patients affected by idiopathic thrombocytopenic purpura: a GIMEMA experience","volume":"109","author":"Mazzucconi","year":"2007","journal-title":"Blood"},{"issue":"21","key":"2022122916265098700_bib16","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1056\/NEJMoa1605949","article-title":"TP53 and decitabine in acute myeloid leukemia and myelodysplastic syndromes","volume":"375","author":"Welch","year":"2016","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"2022122916265098700_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1001\/jamaoncol.2014.316","article-title":"Low-dose decitabine for patients with thrombocytopenia following allogeneic hematopoietic stem cell transplantation: a pilot therapeutic study","volume":"1","author":"Han","year":"2015","journal-title":"JAMA Oncol"},{"issue":"Suppl 1","key":"2022122916265098700_bib18","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1053\/j.seminhematol.2013.03.022","article-title":"DNA methylation and primary immune thrombocytopenia","volume":"50","author":"Li","year":"2013","journal-title":"Semin Hematol"},{"issue":"12","key":"2022122916265098700_bib19","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/ajh.25646","article-title":"A\u00a0prospective, multicenter study of low dose decitabine in adult patients with refractory immune thrombocytopenia","volume":"94","author":"Zhou","year":"2019","journal-title":"Am J Hematol"},{"issue":"05","key":"2022122916265098700_bib20","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1160\/TH14-04-0342","article-title":"Low-dose decitabine promotes megakaryocyte maturation and platelet production in healthy controls and immune thrombocytopenia","volume":"113","author":"Zhou","year":"2015","journal-title":"Thromb Haemost"},{"key":"2022122916265098700_bib21","doi-asserted-by":"crossref","first-page":"630693","DOI":"10.3389\/fimmu.2021.630693","article-title":"Low-dose decitabine inhibits cytotoxic T lymphocytes-mediated platelet destruction via modulating PD-1 methylation in immune thrombocytopenia","volume":"12","author":"Han","year":"2021","journal-title":"Front Immunol"},{"issue":"8","key":"2022122916265098700_bib22","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1182\/blood.2020008477","article-title":"Low-dose decitabine modulates T-cell homeostasis and restores immune tolerance in immune thrombocytopenia","volume":"138","author":"Han","year":"2021","journal-title":"Blood"},{"issue":"8","key":"2022122916265098700_bib23","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc2676","article-title":"The LKB1\u2013AMPK pathway: metabolism and growth control in tumour suppression","volume":"9","author":"Shackelford","year":"2009","journal-title":"Nat Rev Cancer"},{"issue":"7669","key":"2022122916265098700_bib24","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/nature23665","article-title":"Homeostatic control of metabolic and functional fitness of T reg cells by LKB1 signalling","volume":"548","author":"Yang","year":"2017","journal-title":"Nature"},{"issue":"5","key":"2022122916265098700_bib25","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41422-019-0161-8","article-title":"LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells","volume":"29","author":"Pelgrom","year":"2019","journal-title":"Cell Res"},{"issue":"10","key":"2022122916265098700_bib26","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1016\/j.celrep.2019.05.020","article-title":"Activation of mevalonate pathway via LKB1 is essential for stability of Treg cells","volume":"27","author":"Timilshina","year":"2019","journal-title":"Cell Rep"},{"issue":"47","key":"2022122916265098700_bib27","doi-asserted-by":"crossref","first-page":"12542","DOI":"10.1073\/pnas.1715363114","article-title":"Metabolic control of regulatory T cell (Treg) survival and function by Lkb1","volume":"114","author":"He","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2022122916265098700_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms15876","article-title":"Lkb1 maintains T reg cell lineage identity","volume":"8","author":"Wu","year":"2017","journal-title":"Nat Commun"},{"issue":"9","key":"2022122916265098700_bib29","doi-asserted-by":"crossref","first-page":"16698","DOI":"10.3390\/ijms150916698","article-title":"Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function","volume":"15","author":"Gan","year":"2014","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2022122916265098700_bib30","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1182\/blood-2009-09-244772","article-title":"A\u00a0murine model of severe immune thrombocytopenia is induced by antibody-and CD8+ T cell\u2013mediated responses that are differentially sensitive to therapy","volume":"115","author":"Chow","year":"2010","journal-title":"Blood"},{"issue":"10","key":"2022122916265098700_bib31","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1182\/blood-2012-02-413526","article-title":"Thymic retention of CD4+ CD25+ FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia","volume":"120","author":"Aslam","year":"2012","journal-title":"Blood"},{"issue":"6","key":"2022122916265098700_bib32","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s12185-018-2445-z","article-title":"Chinese guidelines for treatment of adult primary immune thrombocytopenia","volume":"107","author":"Liu","year":"2018","journal-title":"Int J Hematol"},{"issue":"8","key":"2022122916265098700_bib33","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.humimm.2016.05.024","article-title":"Myeloid derived suppressor cells and autoimmunity","volume":"77","author":"Boros","year":"2016","journal-title":"Hum Immunol"},{"issue":"2","key":"2022122916265098700_bib34","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/art.39441","article-title":"Elimination of granulocytic myeloid-derived suppressor cells in lupus-prone mice linked to reactive oxygen species\u2013dependent extracellular trap formation","volume":"68","author":"Vlachou","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2022122916265098700_bib35","doi-asserted-by":"crossref","first-page":"12150","DOI":"10.1038\/ncomms12150","article-title":"Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards","volume":"7","author":"Bronte","year":"2016","journal-title":"Nat Commun"},{"issue":"3","key":"2022122916265098700_bib36","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"2022122916265098700_bib37","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s10875-012-9861-2","article-title":"Clinical significance and functional studies of myeloid-derived suppressor cells in chronic hepatitis C patients","volume":"33","author":"Cai","year":"2013","journal-title":"J\u00a0Clin Immunol"},{"issue":"10","key":"2022122916265098700_bib38","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nrc3581","article-title":"History of myeloid-derived suppressor cells","volume":"13","author":"Talmadge","year":"2013","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"2022122916265098700_bib39","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10157-010-0309-9","article-title":"Involvement of CD11b+ GR-1 low cells in autoimmune disorder in MRL-Fas lpr mouse","volume":"14","author":"Iwata","year":"2010","journal-title":"Clin Exp Nephrol"},{"key":"2022122916265098700_bib40","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3389\/fimmu.2020.00687","article-title":"Myeloid-derived suppressor cell-derived arginase-1 oppositely modulates IL-17A and IL-17F through the ESR\/STAT3 pathway during colitis in mice","volume":"11","author":"Ma","year":"2020","journal-title":"Front Immunol"},{"issue":"10","key":"2022122916265098700_bib41","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1084\/jem.20080132","article-title":"Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein","volume":"205","author":"Cheng","year":"2008","journal-title":"J\u00a0Exp Med"},{"issue":"6","key":"2022122916265098700_bib42","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1158\/1078-0432.CCR-09-3272","article-title":"Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer","volume":"16","author":"Nagaraj","year":"2010","journal-title":"Clin Cancer Res"},{"issue":"6","key":"2022122916265098700_bib43","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1084\/jem.20062602","article-title":"MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis","volume":"204","author":"Delano","year":"2007","journal-title":"J\u00a0Exp Med"},{"issue":"4","key":"2022122916265098700_bib44","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.4049\/jimmunol.1101304","article-title":"Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells","volume":"188","author":"Shirota","year":"2012","journal-title":"J\u00a0Immunol"},{"issue":"5","key":"2022122916265098700_bib45","doi-asserted-by":"crossref","first-page":"e2226","DOI":"10.1038\/cddis.2016.132","article-title":"Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer","volume":"7","author":"Qu","year":"2016","journal-title":"Cell Death Dis"},{"issue":"4","key":"2022122916265098700_bib46","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2013.04.005","article-title":"Metabolic pathways in immune cell activation and quiescence","volume":"38","author":"Pearce","year":"2013","journal-title":"Immunity"},{"issue":"8","key":"2022122916265098700_bib47","doi-asserted-by":"crossref","first-page":"e1200771","DOI":"10.1080\/2162402X.2016.1200771","article-title":"Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer","volume":"5","author":"Al-Khami","year":"2016","journal-title":"Oncoimmunology"},{"issue":"5","key":"2022122916265098700_bib48","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1080\/15548627.2020.1752979","article-title":"Autophagy-related protein PIK3C3\/VPS34 controls T cell metabolism and function: PIK3C3\/VPS34 in T cell metabolism and function","volume":"17","author":"Yang","year":"2021","journal-title":"Autophagy"},{"key":"2022122916265098700_bib49","doi-asserted-by":"crossref","first-page":"703972","DOI":"10.3389\/fimmu.2021.703972","article-title":"Targeting mitochondrial-derived reactive oxygen species in T cell-mediated autoimmune diseases","volume":"12","author":"Ch\u00e1vez","year":"2021","journal-title":"Front Immunol"},{"issue":"6","key":"2022122916265098700_bib50","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jhep.2021.07.032","article-title":"Regulatory T cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis","volume":"75","author":"Wang","year":"2021","journal-title":"J\u00a0Hepatol"},{"issue":"4","key":"2022122916265098700_bib51","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/sj.emboj.7600110","article-title":"LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK\/PAR-1","volume":"23","author":"Lizcano","year":"2004","journal-title":"EMBO J"},{"issue":"6","key":"2022122916265098700_bib52","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.febslet.2005.01.042","article-title":"Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate","volume":"579","author":"Jaleel","year":"2005","journal-title":"FEBS Lett"},{"issue":"23","key":"2022122916265098700_bib53","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1038\/s41388-018-0145-z","article-title":"Controlling the master\u2014upstream regulation of the tumor suppressor LKB1","volume":"37","author":"Kullmann","year":"2018","journal-title":"Oncogene"},{"issue":"4","key":"2022122916265098700_bib54","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.4049\/jimmunol.1000901","article-title":"Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells","volume":"185","author":"Lechner","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"2022122916265098700_bib55","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3389\/fimmu.2018.00978","article-title":"Targeting VEGF\/VEGFR to modulate antitumor immunity","volume":"9","author":"Yang","year":"2018","journal-title":"Front Immunol"},{"issue":"4","key":"2022122916265098700_bib56","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/jth.12524","article-title":"Association of autoantibody specificity and response to intravenous immunoglobulin G therapy in immune thrombocytopenia: a multicenter cohort study","volume":"12","author":"Peng","year":"2014","journal-title":"J\u00a0Thromb Haemost"},{"key":"2022122916265098700_bib57","doi-asserted-by":"crossref","first-page":"7737","DOI":"10.1038\/ncomms8737","article-title":"Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia","volume":"6","author":"Li","year":"2015","journal-title":"Nat Commun"},{"issue":"11","key":"2022122916265098700_bib58","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41584-018-0099-0","article-title":"New insights into the genetics and epigenetics of systemic sclerosis","volume":"14","author":"Angiolilli","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"2022122916265098700_bib59","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jaut.2018.09.007","article-title":"Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAI","volume":"96","author":"Joseph","year":"2019","journal-title":"J\u00a0Autoimmun"},{"issue":"12-13","key":"2022122916265098700_bib60","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.molimm.2011.04.012","article-title":"Increased expressions of DNA methyltransferases contribute to CD70 promoter hypomethylation and over expression of CD70 in ITP","volume":"48","author":"Ma","year":"2011","journal-title":"Mol Immunol"},{"issue":"11","key":"2022122916265098700_bib61","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.humimm.2014.09.018","article-title":"Foxp3 methylation status in children with primary immune thrombocytopenia","volume":"75","author":"Chen","year":"2014","journal-title":"Hum Immunol"},{"issue":"24","key":"2022122916265098700_bib62","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1182\/blood-2017-11-785865","article-title":"Immune regulatory cell infusion for graft-versus-host disease prevention and therapy","volume":"131","author":"Blazar","year":"2018","journal-title":"Blood"},{"issue":"2","key":"2022122916265098700_bib63","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.clim.2015.02.001","article-title":"Myeloid-derived suppressor cells are proinflammatory and regulate collagen-induced arthritis through manipulating Th17 cell differentiation","volume":"157","author":"Zhang","year":"2015","journal-title":"Clin Immunol"},{"issue":"10","key":"2022122916265098700_bib64","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1172\/JCI128164","article-title":"Lactoferrin-induced myeloid-derived suppressor cell therapy attenuates pathologic inflammatory conditions in newborn mice","volume":"129","author":"Liu","year":"2019","journal-title":"J\u00a0Clin Invest"},{"issue":"8","key":"2022122916265098700_bib65","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41577-020-00490-y","article-title":"Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity","volume":"21","author":"Veglia","year":"2021","journal-title":"Nat Rev Immunol"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/140\/26\/2818\/2026855\/blood_bld-2022-016029-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/140\/26\/2818\/2026855\/blood_bld-2022-016029-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T16:27:52Z","timestamp":1672331272000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/140\/26\/2818\/486439\/Low-dose-decitabine-modulates-myeloid-derived"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":65,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2022,12,29]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2022016029","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]}}}