{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T10:52:07Z","timestamp":1787223127026,"version":"build-2736575974"},"reference-count":76,"publisher":"American Society of Hematology","issue":"13","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deep vein thrombosis (DVT) is the third most common cause of cardiovascular mortality. Several studies suggest that DVT occurs at the intersection of dysregulated inflammation and coagulation upon activation of inflammasome and secretion of interleukin 1\u03b2 (IL-1\u03b2) in restricted venous flow conditions. Our recent studies showed a signaling adapter protein, Gab2 (Grb2-associated binder 2), plays a crucial role in propagating inflammatory signaling triggered by IL-1\u03b2 and other inflammatory mediators in endothelial cells. The present study shows that Gab2 facilitates the assembly of the CBM (CARMA3 [CARD recruited membrane-associated guanylate kinase protein 3]\u2013BCL-10 [B-cell lymphoma 10]\u2013MALT1 [mucosa-associated lymphoid tissue lymphoma translocation protein 1]) signalosome, which mediates the activation of Rho and NF-\u03baB in endothelial cells. Gene silencing of\u00a0Gab2 or MALT1, the effector signaling molecule in the CBM signalosome, or pharmacological inhibition of MALT1 with a specific inhibitor, mepazine, significantly reduced IL-1\u03b2\u2013induced Rho-dependent exocytosis of P-selectin and von Willebrand factor (VWF) and the subsequent adhesion of neutrophils to endothelial cells. MALT1 inhibition also reduced IL-1\u03b2\u2013induced NF-\u03baB\u2013dependent expression of tissue factor and vascular cell adhesion molecule 1. Consistent with the in\u00a0vitro data, Gab2 deficiency or pharmacological inhibition of MALT1 suppressed the accumulation of monocytes and neutrophils at the injury site and attenuated venous thrombosis induced by the inferior vena cava ligation-induced stenosis or stasis in mice. Overall, our data reveal a previously unrecognized role of the Gab2\u2013MALT1 axis in thromboinflammation. Targeting the Gab2\u2013MALT1 axis with MALT1 inhibitors may become an effective strategy to treat DVT by suppressing thromboinflammation without inducing bleeding complications.<\/jats:p>","DOI":"10.1182\/blood.2022016424","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T19:06:07Z","timestamp":1658948767000},"page":"1549-1564","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":44,"title":["The Gab2\u2013MALT1 axis regulates thromboinflammation and deep vein thrombosis"],"prefix":"10.1182","volume":"140","author":[{"given":"Vijay","family":"Kondreddy","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Keshava","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0386-0543","authenticated-orcid":false,"given":"Kaushik","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-7168","authenticated-orcid":false,"given":"Jhansi","family":"Magisetty","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2099-0585","authenticated-orcid":false,"given":"L. 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Disord."},{"issue":"12","key":"2022092915292583800_B41","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1182\/bloodadvances.2020003041","article-title":"Inflammasome activation promotes venous thrombosis through pyroptosis","volume":"5","author":"Zhang","year":"2021","journal-title":"Blood Adv."},{"issue":"3","key":"2022092915292583800_B42","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1161\/01.ATV.20.3.883","article-title":"Regulated von Willebrand factor secretion is associated with agonist-specific patterns of cytoskeletal remodeling in cultured endothelial cells","volume":"20","author":"Vischer","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"3","key":"2022092915292583800_B43","first-page":"272","article-title":"Differential actions of PAR2 and PAR1 in stimulating human endothelial cell exocytosis and permeability: the role of 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