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Integrated genomic, transcriptomic, and proteomic analyses further demonstrated that the HOXA9-SAFB (H9SB)\u2013chromatin complex associates with nucleosome remodeling and histone deacetylase (NuRD) and HP1\u03b3 to repress the expression of factors associated with differentiation and apoptosis, including NOTCH1, CEBP\u03b4, S100A8, and CDKN1A. Chemical or genetic perturbation of NuRD and HP1\u03b3\u2013associated catalytic activity also triggered differentiation, apoptosis, and the induction of these tumor-suppressive genes. Importantly, this mechanism is operative in other HOXA9-dependent AML genotypes. This mechanistic insight demonstrates the active HOXA9-dependent differentiation block as a potent mechanism of disease maintenance in AML that may be amenable to therapeutic intervention by targeting the H9SB interface and\/or NuRD and HP1\u03b3 activity.<\/jats:p>","DOI":"10.1182\/blood.2022016528","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T22:06:12Z","timestamp":1672265172000},"page":"1737-1754","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":17,"title":["HOXA9 forms a repressive complex with nuclear matrix\u2013associated protein SAFB to maintain acute myeloid leukemia"],"prefix":"10.1182","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8632-4556","authenticated-orcid":false,"given":"Shuchi","family":"Agrawal-Singh","sequence":"first","affiliation":[{"name":"1Wellcome Trust\u2013MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom"},{"name":"2Department of Haematology, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2450-8226","authenticated-orcid":false,"given":"Jaana","family":"Bagri","sequence":"additional","affiliation":[{"name":"1Wellcome Trust\u2013MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom"},{"name":"2Department of Haematology, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1390-6592","authenticated-orcid":false,"given":"George","family":"Giotopoulos","sequence":"additional","affiliation":[{"name":"1Wellcome Trust\u2013MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom"},{"name":"2Department of Haematology, University of Cambridge, Cambridge, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9085-4031","authenticated-orcid":false,"given":"Dhoyazan M. 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