{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:45:46Z","timestamp":1785545146674,"version":"3.56.0"},"reference-count":43,"publisher":"American Society of Hematology","issue":"8","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Burkitt lymphoma (BL) accounts for most pediatric non-Hodgkin lymphomas, being less common but significantly more lethal when diagnosed in adults. Much of the knowledge of the genetics of BL thus far has originated from the study of pediatric BL (pBL), leaving its relationship to adult BL (aBL) and other adult lymphomas not fully explored. We sought to more thoroughly identify the somatic changes that underlie lymphomagenesis in aBL and any molecular features that associate with clinical disparities within and between pBL and aBL. Through comprehensive whole-genome sequencing of 230 BL and 295 diffuse large B-cell lymphoma (DLBCL) tumors, we identified additional significantly mutated genes, including more genetic features that associate with tumor Epstein-Barr virus status, and unraveled new distinct subgroupings within BL and DLBCL with 3 predominantly comprising BLs: DGG-BL (DDX3X, GNA13, and GNAI2), IC-BL (ID3 and CCND3), and Q53-BL (quiet TP53). Each BL subgroup is characterized by combinations of common driver and noncoding mutations caused by aberrant somatic hypermutation. The largest subgroups of BL cases, IC-BL and DGG-BL, are further characterized by distinct biological and gene expression differences. IC-BL and DGG-BL and their prototypical genetic features (ID3 and TP53) had significant associations with patient outcomes that were different among aBL and pBL cohorts. These findings highlight shared pathogenesis between aBL and pBL, and establish genetic subtypes within BL that serve to delineate tumors with distinct molecular features, providing a new framework for epidemiologic, diagnostic, and therapeutic strategies.<\/jats:p>","DOI":"10.1182\/blood.2022016534","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T16:24:18Z","timestamp":1665073458000},"page":"904-916","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":90,"title":["Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma"],"prefix":"10.1182","volume":"141","author":[{"given":"Nicole","family":"Thomas","sequence":"first","affiliation":[{"name":"1Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostiantyn","family":"Dreval","sequence":"additional","affiliation":[{"name":"1Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela S.","family":"Gerhard","sequence":"additional","affiliation":[{"name":"2Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6413-6586","authenticated-orcid":false,"given":"Laura K.","family":"Hilton","sequence":"additional","affiliation":[{"name":"3Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-9257","authenticated-orcid":false,"given":"Jeremy S.","family":"Abramson","sequence":"additional","affiliation":[{"name":"4Center for Lymphoma, Massachusetts General Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Ambinder","sequence":"additional","affiliation":[{"name":"5Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Barta","sequence":"additional","affiliation":[{"name":"6University of Pennsylvania Hospital, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8470-394X","authenticated-orcid":false,"given":"Nancy L.","family":"Bartlett","sequence":"additional","affiliation":[{"name":"7Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Bethony","sequence":"additional","affiliation":[{"name":"8Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishor","family":"Bhatia","sequence":"additional","affiliation":[{"name":"9Lantern Pharma, Inc, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6861-9043","authenticated-orcid":false,"given":"Jay","family":"Bowen","sequence":"additional","affiliation":[{"name":"10Biopathology Center, Nationwide Children's Hospital, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C.","family":"Bryan","sequence":"additional","affiliation":[{"name":"10Biopathology Center, Nationwide Children's Hospital, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-6299","authenticated-orcid":false,"given":"Ethel","family":"Cesarman","sequence":"additional","affiliation":[{"name":"11Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, Cornell University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-661X","authenticated-orcid":false,"given":"Corey","family":"Casper","sequence":"additional","affiliation":[{"name":"12Infectious Disease Research Institute, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Chadburn","sequence":"additional","affiliation":[{"name":"13Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Cruz","sequence":"additional","affiliation":[{"name":"1Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk P.","family":"Dittmer","sequence":"additional","affiliation":[{"name":"14Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen A.","family":"Dyer","sequence":"additional","affiliation":[{"name":"15Clinical Research Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-9391","authenticated-orcid":false,"given":"Pedro","family":"Farinha","sequence":"additional","affiliation":[{"name":"3Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Gastier-Foster","sequence":"additional","affiliation":[{"name":"10Biopathology Center, Nationwide Children's Hospital, Columbus, OH"},{"name":"16Departments of Pathology and Pediatrics, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4727-1425","authenticated-orcid":false,"given":"Alina S.","family":"Gerrie","sequence":"additional","affiliation":[{"name":"3Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4621-1589","authenticated-orcid":false,"given":"Bruno M.","family":"Grande","sequence":"additional","affiliation":[{"name":"17Sage Bionetworks, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1470-8328","authenticated-orcid":false,"given":"Timothy","family":"Greiner","sequence":"additional","affiliation":[{"name":"18Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas B.","family":"Griner","sequence":"additional","affiliation":[{"name":"2Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Gross","sequence":"additional","affiliation":[{"name":"19Center for Global Health, National Cancer Institute, National Institutes of Health, Rockville, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Harris","sequence":"additional","affiliation":[{"name":"20Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Irvin","sequence":"additional","affiliation":[{"name":"21Foundation for Burkitt Lymphoma Research, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-0301","authenticated-orcid":false,"given":"Elaine S.","family":"Jaffe","sequence":"additional","affiliation":[{"name":"22Laboratory of Pathology, Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Henry","sequence":"additional","affiliation":[{"name":"6University of Pennsylvania Hospital, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Huppi","sequence":"additional","affiliation":[{"name":"23Office of HIV\/AIDS Malignancies, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio E.","family":"Leal","sequence":"additional","affiliation":[{"name":"24Programa de Oncovirologia, Instituto Nacional de Cancer Jose de Alencar, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Lee","sequence":"additional","affiliation":[{"name":"25University of North Carolina at Chapel Hill, Chapel Hill, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul","family":"Martin","sequence":"additional","affiliation":[{"name":"21Foundation for Burkitt Lymphoma Research, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Reine","family":"Martin","sequence":"additional","affiliation":[{"name":"21Foundation for Burkitt Lymphoma Research, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-9831","authenticated-orcid":false,"given":"Sam M.","family":"Mbulaiteye","sequence":"additional","affiliation":[{"name":"26Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Mitsuyasu","sequence":"additional","affiliation":[{"name":"27Center for Clinical AIDS Research and Education, University of California Los Angeles, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Morris","sequence":"additional","affiliation":[{"name":"28Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1871-1850","authenticated-orcid":false,"given":"Charles G.","family":"Mullighan","sequence":"additional","affiliation":[{"name":"29Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0905-2742","authenticated-orcid":false,"given":"Andrew J.","family":"Mungall","sequence":"additional","affiliation":[{"name":"30Canada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Mungall","sequence":"additional","affiliation":[{"name":"30Canada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Innocent","family":"Mutyaba","sequence":"additional","affiliation":[{"name":"31Uganda Cancer Institute, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Nokta","sequence":"additional","affiliation":[{"name":"23Office of HIV\/AIDS Malignancies, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Namirembe","sequence":"additional","affiliation":[{"name":"31Uganda Cancer Institute, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3001-4898","authenticated-orcid":false,"given":"Ariela","family":"Noy","sequence":"additional","affiliation":[{"name":"32Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin D.","family":"Ogwang","sequence":"additional","affiliation":[{"name":"33EMBLEM Study, St. Mary's Hospital Lacor, Gulu, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Omoding","sequence":"additional","affiliation":[{"name":"31Uganda Cancer Institute, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-9010","authenticated-orcid":false,"given":"Jackson","family":"Orem","sequence":"additional","affiliation":[{"name":"31Uganda Cancer Institute, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"German","family":"Ott","sequence":"additional","affiliation":[{"name":"34Department of Clinical Pathology, Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Petrello","sequence":"additional","affiliation":[{"name":"10Biopathology Center, Nationwide Children's Hospital, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7688-1439","authenticated-orcid":false,"given":"Stefania","family":"Pittaluga","sequence":"additional","affiliation":[{"name":"22Laboratory of Pathology, Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Phelan","sequence":"additional","affiliation":[{"name":"28Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Ramos","sequence":"additional","affiliation":[{"name":"35Department of Medicine, Division of Hematology, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Ratner","sequence":"additional","affiliation":[{"name":"7Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"36Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0724-461X","authenticated-orcid":false,"given":"Paul G.","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"37Section of Hematology\/Oncology, John H. Stroger Jr Hospital of Cook County, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Sissolak","sequence":"additional","affiliation":[{"name":"38Tygerberg Academic Hospital and Stellenbosch University, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Slack","sequence":"additional","affiliation":[{"name":"3Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaghayegh","family":"Soudi","sequence":"additional","affiliation":[{"name":"1Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3832-3329","authenticated-orcid":false,"given":"Steven H.","family":"Swerdlow","sequence":"additional","affiliation":[{"name":"39Division of Hematopathology, University of Pittsburgh School of Medicine, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Traverse-Glehen","sequence":"additional","affiliation":[{"name":"40Hospices Civils de Lyon, Universit\u00e9 Lyon 1, Service d'Anatomie Pathologique, Hopital Lyon Sud France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wyndham H.","family":"Wilson","sequence":"additional","affiliation":[{"name":"28Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-6517","authenticated-orcid":false,"given":"Jasper","family":"Wong","sequence":"additional","affiliation":[{"name":"3Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3057-1395","authenticated-orcid":false,"given":"Robert","family":"Yarchoan","sequence":"additional","affiliation":[{"name":"23Office of HIV\/AIDS Malignancies, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean C.","family":"ZenKlusen","sequence":"additional","affiliation":[{"name":"41The Cancer Genome Atlas, Center for Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7146-7175","authenticated-orcid":false,"given":"Marco A.","family":"Marra","sequence":"additional","affiliation":[{"name":"30Canada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, BC, Canada"},{"name":"42Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis M.","family":"Staudt","sequence":"additional","affiliation":[{"name":"28Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0435-5947","authenticated-orcid":false,"given":"David W.","family":"Scott","sequence":"additional","affiliation":[{"name":"3Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-7800","authenticated-orcid":false,"given":"Ryan D.","family":"Morin","sequence":"additional","affiliation":[{"name":"1Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada"},{"name":"3Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada"},{"name":"30Canada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"6","key":"2023092918001286300_bib1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/j.1365-2141.2011.09013.x","article-title":"Epidemiology: clues to the pathogenesis of Burkitt lymphoma","volume":"156","author":"Magrath","year":"2012","journal-title":"Br J Haematol"},{"issue":"9822","key":"2023092918001286300_bib2","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S0140-6736(11)61177-X","article-title":"Burkitt\u2019s lymphoma","volume":"379","author":"Molyneux","year":"2012","journal-title":"Lancet"},{"issue":"12","key":"2023092918001286300_bib3","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1182\/blood-2018-09-871418","article-title":"Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma","volume":"133","author":"Grande","year":"2019","journal-title":"Blood"},{"issue":"10","key":"2023092918001286300_bib4","doi-asserted-by":"crossref","first-page":"e1005158","DOI":"10.1371\/journal.ppat.1005158","article-title":"Distinct viral and mutational spectrum of endemic Burkitt lymphoma","volume":"11","author":"Abate","year":"2015","journal-title":"PLoS Pathog"},{"issue":"5","key":"2023092918001286300_bib5","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1158\/1541-7786.MCR-16-0305","article-title":"Comprehensive transcriptome and mutational profiling of endemic Burkitt lymphoma reveals EBV type-specific differences","volume":"15","author":"Kaymaz","year":"2017","journal-title":"Mol Cancer Res"},{"issue":"21","key":"2023092918001286300_bib6","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1182\/blood.2022015854","article-title":"Genomic profiling for clinical decision making in lymphoid neoplasms","volume":"140","author":"de Leval","year":"2022","journal-title":"Blood"},{"issue":"7","key":"2023092918001286300_bib7","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"issue":"1","key":"2023092918001286300_bib8","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1038\/s41467-019-08578-3","article-title":"Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma","volume":"10","author":"L\u00f3pez","year":"2019","journal-title":"Nat Commun"},{"issue":"7793","key":"2023092918001286300_bib9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41586-020-1969-6","article-title":"Pan-cancer analysis of whole genomes","volume":"578","author":"Campbell","year":"2020","journal-title":"Nature"},{"issue":"5","key":"2023092918001286300_bib10","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41591-018-0016-8","article-title":"Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes","volume":"24","author":"Chapuy","year":"2018","journal-title":"Nat Med"},{"issue":"20","key":"2023092918001286300_bib11","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1182\/blood.2019003535","article-title":"Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a Haematological Malignancy Research Network report","volume":"135","author":"Lacy","year":"2020","journal-title":"Blood"},{"issue":"4","key":"2023092918001286300_bib12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ccell.2020.03.015","article-title":"A\u00a0probabilistic classification tool for genetic subtypes of diffuse large B cell lymphoma with therapeutic implications","volume":"37","author":"Wright","year":"2020","journal-title":"Cancer Cell"},{"issue":"3","key":"2023092918001286300_bib13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/PPO.0000000000000450","article-title":"Molecular classification and treatment of diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma","volume":"26","author":"Roschewski","year":"2020","journal-title":"Cancer J"},{"issue":"4","key":"2023092918001286300_bib14","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/bjh.17811","article-title":"Molecular profiling in diffuse large B-cell lymphoma: why so many types of subtypes?","volume":"196","author":"Morin","year":"2022","journal-title":"Br J Haematol"},{"issue":"9","key":"2023092918001286300_bib15","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3324\/haematol.13071","article-title":"Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt\u2019s lymphoma","volume":"93","author":"Salaverria","year":"2008","journal-title":"Haematologica"},{"issue":"3","key":"2023092918001286300_bib16","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1182\/blood-2005-01-0168","article-title":"Immunoglobulin gene analysis reveals 2 distinct cells of origin for EBV-positive and EBV-negative Burkitt lymphomas","volume":"106","author":"Bellan","year":"2005","journal-title":"Blood"},{"issue":"s1","key":"2023092918001286300_bib17","first-page":"51","article-title":"A genomic classification model enables risk stratification of paediatric endemic Burkitt lymphoma: Sixth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma","volume":"182","author":"Zhou","year":"2018","journal-title":"Br J Haematol"},{"issue":"12","key":"2023092918001286300_bib18","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/ng.2469","article-title":"Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing","volume":"44","author":"Richter","year":"2012","journal-title":"Nat Genet"},{"issue":"6","key":"2023092918001286300_bib19","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3324\/haematol.2016.156885","article-title":"Relevance of ID3-TCF3-CCND3 pathway mutations in pediatric aggressive B-cell lymphoma treated according to the non-Hodgkin Lymphoma Berlin-Frankfurt-M\u00fcnster protocols","volume":"102","author":"Rohde","year":"2017","journal-title":"Haematologica"},{"issue":"7","key":"2023092918001286300_bib20","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1038\/s41375-021-01251-z","article-title":"Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas","volume":"35","author":"H\u00fcbschmann","year":"2021","journal-title":"Leukemia"},{"issue":"2","key":"2023092918001286300_bib21","doi-asserted-by":"crossref","first-page":"a014282","DOI":"10.1101\/cshperspect.a014282","article-title":"Oncogenic mechanisms in Burkitt lymphoma","volume":"4","author":"Schmitz","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"12","key":"2023092918001286300_bib22","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/ng.2468","article-title":"The genetic landscape of mutations in Burkitt lymphoma","volume":"44","author":"Love","year":"2012","journal-title":"Nat Genet"},{"issue":"7","key":"2023092918001286300_bib23","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.cell.2014.11.013","article-title":"B\u00a0cell super-enhancers and regulatory clusters recruit AID tumorigenic activity","volume":"159","author":"Qian","year":"2014","journal-title":"Cell"},{"issue":"11","key":"2023092918001286300_bib24","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1182\/bloodadvances.2021006429","article-title":"Shared and distinct genetic features in human and canine B-cell lymphomas","volume":"6","author":"Coyle","year":"2022","journal-title":"Blood Adv"},{"issue":"3","key":"2023092918001286300_bib25","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1200\/JCO.18.01583","article-title":"Double-hit gene expression signature defines a distinct subgroup of germinal center B-cell-like diffuse large B-cell lymphoma","volume":"37","author":"Ennishi","year":"2019","journal-title":"J.\u00a0Clin. Oncol. Off. J. Am. Soc. Clin. Oncol"},{"issue":"15","key":"2023092918001286300_bib26","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1056\/NEJMoa1801445","article-title":"Genetics and pathogenesis of diffuse large B-cell lymphoma","volume":"378","author":"Schmitz","year":"2018","journal-title":"N\u00a0Engl J Med"},{"issue":"19","key":"2023092918001286300_bib27","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1182\/blood.2019001880","article-title":"The whole-genome landscape of Burkitt lymphoma subtypes","volume":"134","author":"Panea","year":"2019","journal-title":"Blood"},{"issue":"14","key":"2023092918001286300_bib28","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1182\/bloodadvances.2018029546","article-title":"Sporadic and endemic Burkitt lymphoma have frequent FOXO1 mutations but distinct hotspots in the AKT recognition motif","volume":"3","author":"Zhou","year":"2019","journal-title":"Blood Adv"},{"issue":"17","key":"2023092918001286300_bib29","doi-asserted-by":"crossref","first-page":"9991","DOI":"10.1073\/pnas.1732008100","article-title":"A\u00a0gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma","volume":"100","author":"Wright","year":"2003","journal-title":"Proc Natl Acad Sc. U S A"},{"issue":"9","key":"2023092918001286300_bib30","doi-asserted-by":"crossref","first-page":"e27813","DOI":"10.1002\/pbc.27813","article-title":"Survival of children with endemic Burkitt lymphoma in a prospective clinical care project in Uganda","volume":"66","author":"McGoldrick","year":"2019","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"2023092918001286300_bib31","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1038\/s41467-022-31355-8","article-title":"Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age","volume":"13","author":"Burkhardt","year":"2022","journal-title":"Nat Commun"},{"issue":"7","key":"2023092918001286300_bib32","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1002\/ijc.24934","article-title":"Trimodal age-specific incidence patterns for\u00a0Burkitt lymphoma in the United States, 1973-2005","volume":"126","author":"Mbulaiteye","year":"2010","journal-title":"Int J Cancer"},{"issue":"6","key":"2023092918001286300_bib33","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/ajh.23187","article-title":"Pediatric, elderly, and emerging adult-onset peaks in Burkitt\u2019s lymphoma incidence diagnosed in four continents, excluding Africa","volume":"87","author":"Mbulaiteye","year":"2012","journal-title":"Am J Hematol"},{"issue":"3","key":"2023092918001286300_bib34","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/bjh.17874","article-title":"Epstein\u2013Barr virus status of sporadic Burkitt lymphoma is associated with patient age and mutational features","volume":"196","author":"Richter","year":"2022","journal-title":"Br J Haematol"},{"issue":"23","key":"2023092918001286300_bib35","first-page":"6547","article-title":"Mapping chromosomal breakpoints of Burkitt\u2019s t(8;14) translocations far upstream of c-myc","volume":"52","author":"Joos","year":"1992","journal-title":"Cancer Res"},{"issue":"8","key":"2023092918001286300_bib36","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1038\/sj.leu.2404753","article-title":"Identification of two distinct MYC breakpoint clusters and their association with various IGH breakpoint regions in the t(8;14) translocations in sporadic Burkitt-lymphoma","volume":"21","author":"Busch","year":"2007","journal-title":"Leukemia"},{"issue":"6769","key":"2023092918001286300_bib37","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"issue":"7","key":"2023092918001286300_bib38","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.3324\/haematol.2017.181024","article-title":"Gene expression profiling reveals a close relationship between follicular lymphoma grade 3A and 3B, but distinct profiles of follicular lymphoma grade 1 and 2","volume":"103","author":"Horn","year":"2018","journal-title":"Haematologica"},{"issue":"23","key":"2023092918001286300_bib39","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMoa055759","article-title":"Molecular diagnosis of Burkitt\u2019s lymphoma","volume":"354","author":"Dave","year":"2006","journal-title":"N\u00a0Engl J Med"},{"issue":"23","key":"2023092918001286300_bib40","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa055351","article-title":"A\u00a0biologic definition of Burkitt\u2019s lymphoma from transcriptional and genomic profiling","volume":"354","author":"Hummel","year":"2006","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"2023092918001286300_bib41","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3390\/hemato3030030","article-title":"Burkitt lymphoma incidence in five continents","volume":"3","author":"Mbulaiteye","year":"2022","journal-title":"Hemato"},{"issue":"9","key":"2023092918001286300_bib42","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/gcc.22268","article-title":"The PCBP1 gene encoding poly(rc) binding protein i is recurrently mutated in Burkitt lymphoma","volume":"54","author":"Wagener","year":"2015","journal-title":"Genes Chromosomes Cancer"},{"issue":"5","key":"2023092918001286300_bib43","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.chom.2017.04.005","article-title":"CRISPR\/Cas9 screens reveal Epstein-Barr virus-transformed B cell host dependency factors","volume":"21","author":"Ma","year":"2017","journal-title":"Cell Host Microbe"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/141\/8\/904\/2082651\/blood_bld-2022-016534-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/141\/8\/904\/2082651\/blood_bld-2022-016534-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T04:50:34Z","timestamp":1728103834000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/141\/8\/904\/486739\/Genetic-subgroups-inform-on-pathobiology-in-adult"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,23]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,2,23]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2022016534","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.05.21267216","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.3410\/f.742352835.793598185","asserted-by":"object"}]},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,23]]}}}