{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:38:31Z","timestamp":1780411111003,"version":"3.54.1"},"reference-count":23,"publisher":"American Society of Hematology","issue":"22","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"DOI":"10.1182\/blood.2022016815","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T20:59:00Z","timestamp":1663966740000},"page":"2403-2407","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":12,"title":["Hybrid immunity in immunocompromised patients with CLL after SARS-CoV-2 infection followed by booster mRNA vaccination"],"prefix":"10.1182","volume":"140","author":[{"given":"Lisa","family":"Blixt","sequence":"first","affiliation":[{"name":"1Department of Hematology, Karolinska University Hospital Solna, Stockholm, Sweden"},{"name":"2Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4615-3614","authenticated-orcid":false,"given":"Yu","family":"Gao","sequence":"additional","affiliation":[{"name":"3Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-0394","authenticated-orcid":false,"given":"David","family":"Wullimann","sequence":"additional","affiliation":[{"name":"3Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Mur\u00e9n Ingelman-Sundberg","sequence":"additional","affiliation":[{"name":"2Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden"},{"name":"4Department of Oncology, Karolinska University Hospital Solna, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Muschiol","sequence":"additional","affiliation":[{"name":"5Department of Clinical Microbiology, Karolinska University Hospital Solna, Stockholm, Sweden"},{"name":"6Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7242-6604","authenticated-orcid":false,"given":"Katie","family":"Healy","sequence":"additional","affiliation":[{"name":"7Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Bogdanovic","sequence":"additional","affiliation":[{"name":"5Department of Clinical Microbiology, Karolinska University Hospital Solna, Stockholm, Sweden"},{"name":"6Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2158-2674","authenticated-orcid":false,"given":"Elisa","family":"Pin","sequence":"additional","affiliation":[{"name":"8Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4657-8532","authenticated-orcid":false,"given":"Peter","family":"Nilsson","sequence":"additional","affiliation":[{"name":"8Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kjellander","sequence":"additional","affiliation":[{"name":"9Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden"},{"name":"10Department of Internal Medicine, Capio St G\u00f6ran Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Grifoni","sequence":"additional","affiliation":[{"name":"11Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[{"name":"11Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA"},{"name":"12Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-4064","authenticated-orcid":false,"given":"Margaret","family":"S\u00e4llberg Chen","sequence":"additional","affiliation":[{"name":"7Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Gustaf","family":"Ljunggren","sequence":"additional","affiliation":[{"name":"3Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Buggert","sequence":"additional","affiliation":[{"name":"3Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6614-5737","authenticated-orcid":false,"given":"Lotta","family":"Hansson","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Karolinska University Hospital Solna, Stockholm, Sweden"},{"name":"2Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"\u00d6sterborg","sequence":"additional","affiliation":[{"name":"1Department of Hematology, Karolinska University Hospital Solna, Stockholm, Sweden"},{"name":"2Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"3","key":"2022120116264088200_bib1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3324\/haematol.2016.151100","article-title":"T\u00a0cells in chronic lymphocytic leukemia display dysregulated expression of immune checkpoints and activation markers","volume":"102","author":"Palma","year":"2017","journal-title":"Haematologica"},{"issue":"2","key":"2022120116264088200_bib2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41375-021-01424-w","article-title":"Covid-19 in patients with chronic\u00a0lymphocytic leukemia: clinical outcome and B- and T-cell immunity during 13 months in consecutive patients","volume":"36","author":"Blixt","year":"2022","journal-title":"Leukemia"},{"issue":"12","key":"2022120116264088200_bib3","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1038\/s41375-021-01450-8","article-title":"COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study","volume":"35","author":"Chatzikonstantinou","year":"2021","journal-title":"Leukemia"},{"issue":"10","key":"2022120116264088200_bib4","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1182\/blood.2020006965","article-title":"Outcomes of COVID-19 in patients with CLL: a multicenter international experience","volume":"136","author":"Mato","year":"2020","journal-title":"Blood"},{"key":"2022120116264088200_bib5","doi-asserted-by":"crossref","first-page":"103705","DOI":"10.1016\/j.ebiom.2021.103705","article-title":"Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial","volume":"74","author":"Bergman","year":"2021","journal-title":"EBioMedicine"},{"issue":"23","key":"2022120116264088200_bib6","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1182\/blood.2021011568","article-title":"Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic lymphocytic leukemia","volume":"137","author":"Herishanu","year":"2021","journal-title":"Blood"},{"issue":"4","key":"2022120116264088200_bib7","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.3324\/haematol.2021.280300","article-title":"T-cell immune responses following vaccination with mRNA BNT162b2 against SARS-CoV-2 in patients with chronic lymphocytic leukemia: results from a prospective open-label clinical trial","volume":"107","author":"Blixt","year":"2022","journal-title":"Haematologica"},{"issue":"6","key":"2022120116264088200_bib8","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ccell.2022.05.001","article-title":"COVID-19 vaccines elicit robust cellular immunity and clinical protection in chronic lymphocytic leukemia","volume":"40","author":"Parry","year":"2022","journal-title":"Cancer Cell"},{"issue":"3","key":"2022120116264088200_bib9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/infdis\/jiab256","article-title":"Persisting salivary IgG against SARS-CoV-2 at 9 months after mild COVID-19: a complementary approach to population surveys","volume":"224","author":"Alkharaan","year":"2021","journal-title":"J\u00a0Infect Dis"},{"issue":"2","key":"2022120116264088200_bib10","first-page":"137","article-title":"Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals","volume":"3","author":"Healy","year":"2022","journal-title":"Med (N Y)"},{"issue":"7","key":"2022120116264088200_bib11","doi-asserted-by":"crossref","first-page":"e1312","DOI":"10.1002\/cti2.1312","article-title":"Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay","volume":"10","author":"Hober","year":"2021","journal-title":"Clin Transl Immunology"},{"issue":"3","key":"2022120116264088200_bib12","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/s41591-022-01700-x","article-title":"Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant","volume":"28","author":"Gao","year":"2022","journal-title":"Nat Med"},{"issue":"5","key":"2022120116264088200_bib13","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1182\/blood.2021014085","article-title":"Efficacy of a third BNT162b2 mRNA COVID-19 vaccine dose in patients with CLL who failed standard 2-dose vaccination","volume":"139","author":"Herishanu","year":"2022","journal-title":"Blood"},{"issue":"3","key":"2022120116264088200_bib14","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3390\/vaccines10030442","article-title":"Cellular immunity-the key to long-term protection in individuals recovered from SARS-CoV-2 and after vaccination","volume":"10","author":"Primorac","year":"2022","journal-title":"Vaccines (Basel)"},{"issue":"14","key":"2022120116264088200_bib15","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1056\/NEJMc2202542","article-title":"Efficacy of a fourth dose of Covid-19 mRNA vaccine against omicron","volume":"386","author":"Regev-Yochay","year":"2022","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"2022120116264088200_bib16","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/s41591-021-01296-8","article-title":"SARS-CoV-2 infection of the oral cavity and saliva","volume":"27","author":"Huang","year":"2021","journal-title":"Nat Med"},{"issue":"4","key":"2022120116264088200_bib17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1001\/jamaneurol.2022.0245","article-title":"Omicron-specific cytotoxic T-cell responses after a third dose of mRNA COVID-19 vaccine among patients with multiple sclerosis treated with ocrelizumab","volume":"79","author":"Madelon","year":"2022","journal-title":"JAMA Neurol"},{"issue":"3","key":"2022120116264088200_bib18","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/bjh.18088","article-title":"The impact of B-cell-directed therapy on SARS-CoV-2 vaccine efficacy in chronic lymphocytic leukaemia","volume":"197","author":"Ujjani","year":"2022","journal-title":"Br J Haematol"},{"issue":"6","key":"2022120116264088200_bib19","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1473-3099(22)00140-2","article-title":"Effectiveness of CoronaVac, ChAdOx1 nCoV-19, BNT162b2, and Ad26.COV2.S among individuals with previous SARS-CoV-2 infection in Brazil: a test-negative, case-control study","volume":"22","author":"Cerqueira-Silva","year":"2022","journal-title":"Lancet Infect Dis"},{"issue":"13","key":"2022120116264088200_bib20","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMoa2118691","article-title":"Protection against SARS-CoV-2 after Covid-19 vaccination and previous infection","volume":"386","author":"Hall","year":"2022","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"2022120116264088200_bib21","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1473-3099(22)00143-8","article-title":"Risk of SARS-CoV-2 reinfection and COVID-19 hospitalisation in individuals with natural and hybrid immunity: a retrospective, total population cohort study in Sweden","volume":"22","author":"Nordstrom","year":"2022","journal-title":"Lancet Infect Dis"},{"key":"2022120116264088200_bib22","doi-asserted-by":"crossref","first-page":"103938","DOI":"10.1016\/j.ebiom.2022.103938","article-title":"Sub-optimal neutralisation of omicron (B.1.1.529) variant by antibodies induced by vaccine alone or SARS-CoV-2 Infection plus vaccine (hybrid immunity) post 6-months","volume":"78","author":"Medigeshi","year":"2022","journal-title":"EBioMedicine"},{"issue":"1","key":"2022120116264088200_bib23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41467-021-27649-y","article-title":"Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents","volume":"13","author":"Koerber","year":"2022","journal-title":"Nat Commun"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/140\/22\/2403\/2019159\/blood_bld-2022-016815-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/140\/22\/2403\/2019159\/blood_bld-2022-016815-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T18:58:25Z","timestamp":1669921105000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/140\/22\/2403\/486704\/Hybrid-immunity-in-immunocompromised-patients-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":23,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2022,12,1]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2022016815","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,1]]}}}