{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:06:39Z","timestamp":1790514399713,"version":"4.1.0"},"reference-count":64,"publisher":"American Society of Hematology","issue":"7","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Extramedullary infiltration (EMI) is a concomitant manifestation that may indicate poor outcome of acute myeloid leukemia (AML). The underlying mechanism remains poorly understood and therapeutic options are limited. Here, we employed single-cell RNA sequencing on bone marrow (BM) and EMI samples from a patient with AML presenting pervasive leukemia cutis. A complement C1Q+ macrophage-like leukemia subset, which was enriched within cutis and existed in BM before EMI manifestations, was identified and further verified in multiple patients with AML. Genomic and transcriptional profiling disclosed mutation and gene expression signatures of patients with EMI that expressed high levels of C1Q. RNA sequencing and quantitative proteomic analysis revealed expression dynamics of C1Q from primary to relapse. Univariate and multivariate analysis demonstrated adverse prognosis significance of C1Q expression. Mechanistically, C1Q expression, which was modulated by transcription factor MAF BZIP transcription factor B, endowed leukemia cells with tissue infiltration ability, which could establish prominent cutaneous or gastrointestinal EMI nodules in patient-derived xenograft and cell line\u2013derived xenograft models. Fibroblasts attracted migration of the C1Q+ leukemia cells through C1Q\u2013globular C1Q receptor recognition and subsequent stimulation of transforming growth factor \u03b21. This cell-to-cell communication also contributed to survival of C1Q+ leukemia cells under chemotherapy stress. Thus, C1Q served as a marker for AML with adverse prognosis, orchestrating cancer infiltration pathways through communicating with fibroblasts and represents a compelling therapeutic target for EMI.<\/jats:p>","DOI":"10.1182\/blood.2022017046","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T21:07:39Z","timestamp":1667423259000},"page":"766-786","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":42,"title":["C1Q labels a highly aggressive macrophage-like leukemia population indicating extramedullary infiltration and relapse"],"prefix":"10.1182","volume":"141","author":[{"given":"Li-Xue","family":"Yang","sequence":"first","affiliation":[{"name":"1Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"2Department of Hematology, Liaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational Medicine, Liaoning Medical Center for Hematopoietic Stem Cell Transplantation, Dalian Key Laboratory of Hematology, Diamond Bay Institute of Hematology, The Second Hospital of Dalian Medical University, Dalian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"1Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8040-4141","authenticated-orcid":false,"given":"Xue-Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"3Center of Genome and Personalized Medicine, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"2Department of Hematology, Liaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational Medicine, Liaoning Medical Center for Hematopoietic Stem Cell Transplantation, Dalian Key Laboratory of Hematology, Diamond Bay Institute of Hematology, The Second Hospital of Dalian Medical University, Dalian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Hui","family":"Luo","sequence":"additional","affiliation":[{"name":"1Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jiang","sequence":"additional","affiliation":[{"name":"2Department of Hematology, Liaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational Medicine, Liaoning Medical Center for Hematopoietic Stem Cell Transplantation, Dalian Key Laboratory of Hematology, Diamond Bay Institute of Hematology, The Second Hospital of Dalian Medical University, Dalian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang-Man","family":"Wang","sequence":"additional","affiliation":[{"name":"2Department of Hematology, Liaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational Medicine, Liaoning Medical Center for Hematopoietic Stem Cell Transplantation, Dalian Key Laboratory of Hematology, Diamond Bay Institute of Hematology, The Second Hospital of Dalian Medical University, Dalian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Yin","family":"Yang","sequence":"additional","affiliation":[{"name":"4Department of General Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Peng","family":"Shi","sequence":"additional","affiliation":[{"name":"5Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Basic Medical Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ci","family":"Yang","sequence":"additional","affiliation":[{"name":"2Department of Hematology, Liaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational Medicine, Liaoning Medical Center for Hematopoietic Stem Cell Transplantation, Dalian Key Laboratory of Hematology, Diamond Bay Institute of Hematology, The Second Hospital of Dalian Medical University, Dalian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-Qu","family":"Wei","sequence":"additional","affiliation":[{"name":"1Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"5Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Basic Medical Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5788-3965","authenticated-orcid":false,"given":"Jun","family":"Mi","sequence":"additional","affiliation":[{"name":"5Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Basic Medical Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2555-5091","authenticated-orcid":false,"given":"Ai-Wu","family":"Zhou","sequence":"additional","affiliation":[{"name":"5Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Basic Medical Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Rong","family":"Yao","sequence":"additional","affiliation":[{"name":"1Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xia","sequence":"additional","affiliation":[{"name":"5Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Basic Medical Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-2602","authenticated-orcid":false,"given":"Jin-Song","family":"Yan","sequence":"additional","affiliation":[{"name":"2Department of Hematology, Liaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational Medicine, Liaoning Medical Center for Hematopoietic Stem Cell Transplantation, Dalian Key Laboratory of Hematology, Diamond Bay Institute of Hematology, The Second Hospital of Dalian Medical University, Dalian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"1Institute of Dermatology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"4","key":"2023092214542663000_bib1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nm.4529","article-title":"Predicting leukemia relapse","volume":"24","author":"Martin-Subero","year":"2018","journal-title":"Nat Med"},{"issue":"21","key":"2023092214542663000_bib2","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1056\/NEJMoa1605949","article-title":"TP53 and decitabine in acute myeloid leukemia and myelodysplastic syndromes","volume":"375","author":"Welch","year":"2016","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"2023092214542663000_bib3","first-page":"305","article-title":"Genetics: the AML mutational landscape","volume":"10","author":"Marchesi","year":"2013","journal-title":"Nat Rev Clin Oncol"},{"issue":"2","key":"2023092214542663000_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/MOH.0000000000000571","article-title":"Myeloid sarcoma","volume":"27","author":"Shahin","year":"2020","journal-title":"Curr Opin Hematol"},{"issue":"14","key":"2023092214542663000_bib5","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1182\/blood-2011-04-347229","article-title":"How I treat extramedullary acute myeloid leukemia","volume":"118","author":"Bakst","year":"2011","journal-title":"Blood"},{"issue":"10","key":"2023092214542663000_bib6","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.leukres.2004.01.006","article-title":"Extramedullary infiltrates of AML are associated with CD56 expression, 11q23 abnormalities and inferior clinical outcome","volume":"28","author":"Chang","year":"2004","journal-title":"Leuk Res"},{"issue":"19","key":"2023092214542663000_bib7","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1038\/s41388-021-01775-9","article-title":"miR-29c&b2 encourage extramedullary infiltration resulting in the poor prognosis of acute myeloid leukemia","volume":"40","author":"Wei","year":"2021","journal-title":"Oncogene"},{"issue":"13","key":"2023092214542663000_bib8","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1182\/blood-2002-03-0772","article-title":"Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)","volume":"100","author":"Byrd","year":"2002","journal-title":"Blood"},{"issue":"6","key":"2023092214542663000_bib9","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.3324\/haematol.2019.223032","article-title":"The prevalence of extramedullary acute myeloid leukemia detected by (18)FDG-PET\/CT: final results from the prospective PETAML trial","volume":"105","author":"Stolzel","year":"2020","journal-title":"Haematologica"},{"issue":"1","key":"2023092214542663000_bib10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13045-022-01267-7","article-title":"Molecular profiling and clinical implications of patients with acute myeloid leukemia and extramedullary manifestations","volume":"15","author":"Eckardt","year":"2022","journal-title":"J\u00a0Hematol Oncol"},{"issue":"4","key":"2023092214542663000_bib11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/ejh.12085","article-title":"Extramedullary disease in patients with acute myeloid leukemia assessed by 18F-FDG PET","volume":"90","author":"Cribe","year":"2013","journal-title":"Eur J Haematol"},{"issue":"29","key":"2023092214542663000_bib12","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1200\/JCO.2016.67.5892","article-title":"Extramedullary disease in adult acute myeloid leukemia is common but lacks independent significance: analysis of patients in ECOG-ACRIN Cancer Research Group trials, 1980-2008","volume":"34","author":"Ganzel","year":"2016","journal-title":"J\u00a0Clin Oncol"},{"issue":"7","key":"2023092214542663000_bib13","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1200\/JCO.1995.13.7.1800","article-title":"Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: a clinical review","volume":"13","author":"Byrd","year":"1995","journal-title":"J\u00a0Clin Oncol"},{"issue":"7","key":"2023092214542663000_bib14","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1001\/jamadermatol.2019.0052","article-title":"Association of leukemia cutis with survival in acute myeloid leukemia","volume":"155","author":"Wang","year":"2019","journal-title":"JAMA Dermatol"},{"issue":"5","key":"2023092214542663000_bib15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.blre.2016.04.001","article-title":"Extramedullary acute myelogenous leukemia","volume":"30","author":"Solh","year":"2016","journal-title":"Blood Rev"},{"issue":"7","key":"2023092214542663000_bib16","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1503\/cmaj.080674","article-title":"Granulocytic sarcoma of the skin","volume":"179","author":"Pirisi","year":"2008","journal-title":"Can Med Assoc J"},{"issue":"1","key":"2023092214542663000_bib17","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbmt.2011.05.023","article-title":"Extramedullary relapse of acute myelogenous leukemia after allogeneic hematopoietic stem cell transplantation: better prognosis than systemic relapse","volume":"18","author":"Solh","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"2023092214542663000_bib18","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/ejh.12909","article-title":"Extramedullary disease at diagnosis of AML does not influence outcome of patients undergoing allogeneic hematopoietic cell transplant in CR1","volume":"99","author":"Bourlon","year":"2017","journal-title":"Eur J Haematol"},{"issue":"2","key":"2023092214542663000_bib19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s00277-001-0412-9","article-title":"A\u00a0comparative study on demographic, hematological, and cytogenetic findings and prognosis in acute myeloid leukemia with and without leukemia cutis","volume":"81","author":"Agis","year":"2002","journal-title":"Ann Hematol"},{"issue":"11","key":"2023092214542663000_bib20","doi-asserted-by":"crossref","first-page":"e813","DOI":"10.1016\/j.clml.2020.06.009","article-title":"Prognostic impact of extramedullary infiltration in pediatric low-risk acute myeloid leukemia: a retrospective single-center study over 10 years","volume":"20","author":"Hu","year":"2020","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"4","key":"2023092214542663000_bib21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/pbc.20824","article-title":"Extramedullary infiltration at diagnosis and prognosis in children with acute myelogenous leukemia","volume":"48","author":"Kobayashi","year":"2007","journal-title":"Pediatr Blood Cancer"},{"issue":"3","key":"2023092214542663000_bib22","first-page":"250","article-title":"Prognostic significance of CD56 antigen expression in acute myeloid leukemia","volume":"87","author":"Di Bona","year":"2002","journal-title":"Haematologica"},{"issue":"1","key":"2023092214542663000_bib23","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1309\/WYACYWF6NGM3WBRT","article-title":"Leukemia cutis","volume":"129","author":"Cho-Vega","year":"2008","journal-title":"Am J Clin Pathol"},{"issue":"24","key":"2023092214542663000_bib24","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1182\/bloodadvances.2019000647","article-title":"How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?","volume":"3","author":"Garnache-Ottou","year":"2019","journal-title":"Blood Adv"},{"issue":"6","key":"2023092214542663000_bib25","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.cell.2019.01.031","article-title":"Single-cell RNA-seq reveals AML hierarchies relevant to disease progression and immunity","volume":"176","author":"van Galen","year":"2019","journal-title":"Cell"},{"issue":"1","key":"2023092214542663000_bib26","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1038\/s41467-019-10291-0","article-title":"A\u00a0comprehensive single cell transcriptional landscape of human hematopoietic progenitors","volume":"10","author":"Pellin","year":"2019","journal-title":"Nat Commun"},{"issue":"6","key":"2023092214542663000_bib27","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41556-020-0512-1","article-title":"Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis","volume":"22","author":"Dong","year":"2020","journal-title":"Nat Cell Biol"},{"issue":"7813","key":"2023092214542663000_bib28","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41586-020-2316-7","article-title":"Deciphering human macrophage development at single-cell resolution","volume":"582","author":"Bian","year":"2020","journal-title":"Nature"},{"issue":"4","key":"2023092214542663000_bib29","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s41593-020-00789-y","article-title":"Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization","volume":"24","author":"Pombo Antunes","year":"2021","journal-title":"Nat Neurosci"},{"key":"2023092214542663000_bib30","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.3389\/fimmu.2020.01070","article-title":"Human monocyte subset distinctions and function: insights from gene expression analysis","volume":"11","author":"Cormican","year":"2020","journal-title":"Front Immunol"},{"issue":"11","key":"2023092214542663000_bib31","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1016\/j.cell.2021.04.038","article-title":"Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages","volume":"184","author":"Obradovic","year":"2021","journal-title":"Cell"},{"issue":"7","key":"2023092214542663000_bib32","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.ccell.2021.04.016","article-title":"The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor\u00a0growth","volume":"39","author":"Dong","year":"2021","journal-title":"Cancer Cell"},{"issue":"2","key":"2023092214542663000_bib33","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.cell.2020.03.048","article-title":"Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer","volume":"181","author":"Zhang","year":"2020","journal-title":"Cell"},{"issue":"9","key":"2023092214542663000_bib34","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/emboj\/19.9.1987","article-title":"MafB is an inducer of monocytic differentiation","volume":"19","author":"Kelly","year":"2000","journal-title":"EMBO J"},{"issue":"1","key":"2023092214542663000_bib35","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1038\/s41467-017-01711-0","article-title":"MafB is a critical regulator of complement component C1q","volume":"8","author":"Tran","year":"2017","journal-title":"Nat Commun"},{"issue":"7728","key":"2023092214542663000_bib36","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41586-018-0623-z","article-title":"Functional genomic landscape of acute myeloid leukaemia","volume":"562","author":"Tyner","year":"2018","journal-title":"Nature"},{"issue":"1","key":"2023092214542663000_bib37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13045-016-0337-3","article-title":"DNMT3A mutation leads to leukemic extramedullary infiltration mediated by TWIST1","volume":"9","author":"Xu","year":"2016","journal-title":"J\u00a0Hematol Oncol"},{"issue":"22","key":"2023092214542663000_bib38","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia","volume":"368","author":"Ley","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"2023092214542663000_bib39","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1182\/blood-2016-08-733196","article-title":"Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel","volume":"129","author":"Dohner","year":"2017","journal-title":"Blood"},{"key":"2023092214542663000_bib40","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3389\/fimmu.2014.00278","article-title":"Monocyte expressed macromolecular C1 and C1q receptors as molecular sensors of danger: implications in SLE","volume":"5","author":"Ghebrehiwet","year":"2014","journal-title":"Front Immunol"},{"key":"2023092214542663000_bib41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3389\/fimmu.2019.00333","article-title":"Chemokines modulate immune surveillance in tumorigenesis, metastasis, and response to immunotherapy","volume":"10","author":"Vilgelm","year":"2019","journal-title":"Front Immunol"},{"issue":"9","key":"2023092214542663000_bib42","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"2023092214542663000_bib43","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3389\/fimmu.2016.00398","article-title":"Editorial: state-of-the-art research on C1q and the classical complement pathway","volume":"7","author":"Kishore","year":"2016","journal-title":"Front Immunol"},{"issue":"2","key":"2023092214542663000_bib44","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.molimm.2014.06.011","article-title":"cC1qR\/CR and gC1qR\/p33: observations in cancer","volume":"61","author":"Peerschke","year":"2014","journal-title":"Mol Immunol"},{"issue":"7","key":"2023092214542663000_bib45","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.1074\/jbc.M110.161927","article-title":"The multicompartmental p32\/gClqR as a new target for antibody-based tumor targeting strategies","volume":"286","author":"Sanchez-Martin","year":"2011","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"2023092214542663000_bib46","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s42003-020-0922-4","article-title":"Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming","volume":"3","author":"Sole-Boldo","year":"2020","journal-title":"Commun Biol"},{"issue":"1","key":"2023092214542663000_bib47","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1038\/s41467-021-24110-y","article-title":"Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases","volume":"12","author":"Deng","year":"2021","journal-title":"Nat Commun"},{"issue":"7891","key":"2023092214542663000_bib48","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41586-021-04221-8","article-title":"Anatomically distinct fibroblast subsets determine skin autoimmune patterns","volume":"601","author":"Xu","year":"2022","journal-title":"Nature"},{"issue":"2","key":"2023092214542663000_bib49","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.imlet.2010.03.012","article-title":"The non-classical functions of the classical complement pathway recognition subcomponent C1q","volume":"131","author":"Nayak","year":"2010","journal-title":"Immunol Lett"},{"issue":"3","key":"2023092214542663000_bib50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41568-021-00427-0","article-title":"Towards targeting of shared mechanisms of cancer metastasis and therapy resistance","volume":"22","author":"Weiss","year":"2022","journal-title":"Nat Rev Cancer"},{"issue":"13","key":"2023092214542663000_bib51","doi-asserted-by":"crossref","first-page":"6923","DOI":"10.3390\/ijms22136923","article-title":"The influence of cell cycle regulation on chemotherapy","volume":"22","author":"Sun","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2023092214542663000_bib52","doi-asserted-by":"crossref","first-page":"188444","DOI":"10.1016\/j.bbcan.2020.188444","article-title":"Cancer-associated fibroblasts in therapeutic resistance of pancreatic cancer: Present situation, predicaments, and perspectives","volume":"1874","author":"Han","year":"2020","journal-title":"Biochim Biophys Acta Rev Cancer"},{"issue":"11","key":"2023092214542663000_bib53","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.3324\/haematol.2021.279889","article-title":"The NADPH oxidase NOX2 is a marker of adverse prognosis involved in chemoresistance of acute myeloid leukemias","volume":"107","author":"Paolillo","year":"2022","journal-title":"Haematologica"},{"issue":"10","key":"2023092214542663000_bib54","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.3109\/10428194.2015.1015123","article-title":"DNMT3A R882 mutation is associated with elevated expression of MAFB and M4\/M5 immunophenotype of acute myeloid leukemia blasts","volume":"56","author":"Yang","year":"2015","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"2023092214542663000_bib55","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1038\/s41467-021-22041-2","article-title":"Aberrant TGF-beta1 signaling activation by MAF underlies pathological lens growth in high myopia","volume":"12","author":"Zhu","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"2023092214542663000_bib56","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41591-019-0733-7","article-title":"Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report","volume":"26","author":"Kim","year":"2020","journal-title":"Nat Med"},{"issue":"1","key":"2023092214542663000_bib57","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1038\/s41467-020-17834-w","article-title":"Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm","volume":"11","author":"Guo","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"2023092214542663000_bib58","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13073-020-00741-6","article-title":"Single-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer patient","volume":"12","author":"Lee","year":"2020","journal-title":"Genome Med"},{"issue":"1","key":"2023092214542663000_bib59","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0090-1229(90)90014-H","article-title":"Interaction of C1q with its receptor on cultured cell lines induces an anti-proliferative response","volume":"54","author":"Ghebrehiwet","year":"1990","journal-title":"Clin Immunol Immunopathol"},{"key":"2023092214542663000_bib60","doi-asserted-by":"crossref","first-page":"10346","DOI":"10.1038\/ncomms10346","article-title":"C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation","volume":"7","author":"Bulla","year":"2016","journal-title":"Nat Commun"},{"issue":"11","key":"2023092214542663000_bib61","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/ni.1655","article-title":"Modulation of the antitumor immune response by complement","volume":"9","author":"Markiewski","year":"2008","journal-title":"Nat Immunol"},{"issue":"10","key":"2023092214542663000_bib62","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1007\/s00262-005-0672-7","article-title":"Expression of complement protein C5a in a murine mammary cancer model: tumor regression by interference with the cell cycle","volume":"54","author":"Kim","year":"2005","journal-title":"Cancer Immunol Immunother"},{"issue":"1-2","key":"2023092214542663000_bib63","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0162-3109(00)80301-X","article-title":"C1q: structure, function, and receptors","volume":"49","author":"Kishore","year":"2000","journal-title":"Immunopharmacology"},{"issue":"26","key":"2023092214542663000_bib64","doi-asserted-by":"crossref","first-page":"23093","DOI":"10.1074\/jbc.M111.233304","article-title":"Cell-surface receptor for complement component C1q (gC1qR) is a key regulator for lamellipodia formation and cancer metastasis","volume":"286","author":"Kim","year":"2011","journal-title":"J\u00a0Biol Chem"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/141\/7\/766\/2079741\/blood_bld-2022-017046-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/141\/7\/766\/2079741\/blood_bld-2022-017046-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T14:55:05Z","timestamp":1695394505000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/141\/7\/766\/486969\/C1Q-labels-a-highly-aggressive-macrophage-like"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,16]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,2,16]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2022017046","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,16]]}}}