{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T03:40:31Z","timestamp":1787197231805,"version":"build-2736575974"},"reference-count":44,"publisher":"American Society of Hematology","issue":"25","content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although altruistic regular blood donors are vital for the blood supply, many become iron deficient from donation-induced iron loss. The effects of blood donation\u2013induced iron deficiency on red cell transfusion quality or donor cognition are unknown. In this double-blind, randomized trial, adult iron-deficient blood donors (n\u00a0= 79; ferritin\u00a0&amp;lt; 15 \u03bcg\/L and zinc protoporphyrin &amp;gt;60 \u03bcMol\/mol heme) who met donation qualifications were enrolled. A first standard blood donation was followed by the gold-standard measure for red cell storage quality: a 51-chromium posttransfusion red cell recovery study. Donors were then randomized to intravenous iron repletion (1 g low-molecular-weight iron dextran) or placebo. A second donation \u223c5 months later was followed by another recovery study. Primary outcome was the within-subject change in posttransfusion recovery. The primary outcome measure of an ancillary study reported here was the National Institutes of Health Toolbox\u2013derived uncorrected standard Cognition Fluid Composite Score. Overall, 983\u00a0donors were screened; 110 were iron-deficient, and of these, 39 were randomized to iron repletion and 40 to placebo. Red cell storage quality was unchanged by iron repletion: mean change in posttransfusion recovery was 1.6% (95% confidence interval\u00a0\u22120.5 to 3.8) and\u00a0\u22120.4% (\u22122.0 to 1.2) with and without iron, respectively. Iron repletion did not affect any cognition or well-being measures. These data provide evidence that current criteria for blood donation preserve red cell transfusion quality for the recipient and protect adult donors from measurable effects of blood donation\u2013induced iron deficiency on cognition. This trial was registered at www.clinicaltrials.gov as NCT02889133 and NCT02990559.<\/jats:p>","DOI":"10.1182\/blood.2022017288","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T13:03:57Z","timestamp":1662555837000},"page":"2730-2739","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":24,"title":["A randomized trial of blood donor iron repletion on red cell quality for transfusion and donor cognition and well-being"],"prefix":"10.1182","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-9509","authenticated-orcid":false,"given":"Eldad A.","family":"Hod","sequence":"first","affiliation":[{"name":"1Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Brittenham","sequence":"additional","affiliation":[{"name":"2Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY"},{"name":"3Department of Medicine, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary C.","family":"Bitan","sequence":"additional","affiliation":[{"name":"1Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yona","family":"Feit","sequence":"additional","affiliation":[{"name":"1Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan I.","family":"Gaelen","sequence":"additional","affiliation":[{"name":"1Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-9307","authenticated-orcid":false,"given":"Francesca","family":"La Carpia","sequence":"additional","affiliation":[{"name":"1Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6283-5578","authenticated-orcid":false,"given":"Luke A.","family":"Sandoval","sequence":"additional","affiliation":[{"name":"1Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, 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Cell Biology, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Eng","sequence":"additional","affiliation":[{"name":"5Department of Pharmacy, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Scotto","sequence":"additional","affiliation":[{"name":"5Department of Pharmacy, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Caccappolo","sequence":"additional","affiliation":[{"name":"6Department of Neurology, Division of Cognitive Neuroscience, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, 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