{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:45:20Z","timestamp":1784126720566,"version":"3.55.0"},"reference-count":12,"publisher":"American Society of Hematology","issue":"6","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ashpublications.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2,9]]},"DOI":"10.1182\/blood.2022017871","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T22:05:57Z","timestamp":1667945157000},"page":"677-680","update-policy":"https:\/\/doi.org\/10.1182\/blood.2019cm0000","source":"Crossref","is-referenced-by-count":7,"title":["<i>F9<\/i> mutations causing deletions beyond the serine protease domain confer higher risk for inhibitor development in hemophilia B"],"prefix":"10.1182","volume":"141","author":[{"given":"Guoqing","family":"Liu","sequence":"first","affiliation":[{"name":"1Hemophilia Comprehensive Care Center, Beijing Children's Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1201-7550","authenticated-orcid":false,"given":"Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"1Hemophilia Comprehensive Care Center, Beijing Children's Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1421-4590","authenticated-orcid":false,"given":"Zekun","family":"Li","sequence":"additional","affiliation":[{"name":"1Hemophilia Comprehensive Care Center, Beijing Children's Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5273-145X","authenticated-orcid":false,"given":"Zhenping","family":"Chen","sequence":"additional","affiliation":[{"name":"1Hemophilia Comprehensive Care Center, Beijing Children's Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenman","family":"Wu","sequence":"additional","affiliation":[{"name":"2Faculty of Laboratory Medicine, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4030-209X","authenticated-orcid":false,"given":"Runhui","family":"Wu","sequence":"additional","affiliation":[{"name":"1Hemophilia Comprehensive Care Center, Beijing Children's Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"234","reference":[{"issue":"1","key":"2023082817145271500_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3324\/haematol.2019.239160","article-title":"Inhibitor incidence in an unselected cohort of previously untreated patients with severe haemophilia B: a PedNet study","volume":"106","author":"Male","year":"2021","journal-title":"Haematologica"},{"issue":"6","key":"2023082817145271500_bib2","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1055\/s-0038-1660817","article-title":"Inhibitors in hemophilia B","volume":"44","author":"Santoro","year":"2018","journal-title":"Semin Thromb Hemost"},{"issue":"4","key":"2023082817145271500_bib3","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/mgg3.30","article-title":"The CDC Hemophilia B Mutation Project mutation list: a new online resource","volume":"1","author":"Li","year":"2013","journal-title":"Mol Genet Genomic Med"},{"issue":"2","key":"2023082817145271500_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-0038-1653759","article-title":"The Nijmegen modification of the Bethesda assay for factor VIII:C inhibitors: improved specificity and reliability","volume":"73","author":"Verbruggen","year":"1995","journal-title":"Thromb Haemost"},{"issue":"5","key":"2023082817145271500_bib5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"issue":"4","key":"2023082817145271500_bib6","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/hae.14577","article-title":"Eradication of FIX inhibitor in haemophilia B children using low-dose immune tolerance induction with rituximab-based immunosuppressive agent(s) in China","volume":"28","author":"Li","year":"2022","journal-title":"Haemophilia"},{"issue":"5","key":"2023082817145271500_bib7","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.3390\/ijms23052762","article-title":"The molecular basis of FIX deficiency in hemophilia B","volume":"23","author":"Shen","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2023082817145271500_bib8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1160\/TH12-05-0302","article-title":"Assessment of the F9 genotype-specific FIX inhibitor risks and characterisation of 10 novel severe F9 defects in the first molecular series of Argentinian patients with haemophilia B","volume":"109","author":"Radic","year":"2013","journal-title":"Thromb Haemost"},{"issue":"2","key":"2023082817145271500_bib9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1182\/blood-2013-12-530113","article-title":"The intron-22-inverted F8 locus permits factor VIII synthesis: explanation for low inhibitor risk and a role for pharmacogenomics","volume":"125","author":"Sauna","year":"2015","journal-title":"Blood"},{"issue":"5","key":"2023082817145271500_bib10","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1182\/blood.V98.5.1416","article-title":"Functional mapping of anti-factor IX inhibitors developed in patients with severe hemophilia B","volume":"98","author":"Christophe","year":"2001","journal-title":"Blood"},{"issue":"1","key":"2023082817145271500_bib11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1050-1738(02)00210-4","article-title":"Structure-function relationships in factor IX and factor IXa","volume":"13","author":"Schmidt","year":"2003","journal-title":"Trends Cardiovasc Med"},{"key":"2023082817145271500_bib12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-60327-084-7_6","article-title":"gamma-Glutamate and beta-hydroxyaspartate in proteins","volume":"446","author":"Castellino","year":"2008","journal-title":"Methods Mol Biol"}],"container-title":["Blood"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/141\/6\/677\/2075044\/blood_bld-2022-017871-main.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/ashpublications.org\/blood\/article-pdf\/141\/6\/677\/2075044\/blood_bld-2022-017871-main.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T17:15:05Z","timestamp":1693242905000},"score":1,"resource":{"primary":{"URL":"https:\/\/ashpublications.org\/blood\/article\/141\/6\/677\/487050\/F9-mutations-causing-deletions-beyond-the-serine"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,9]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,2,9]]}},"URL":"https:\/\/doi.org\/10.1182\/blood.2022017871","relation":{},"ISSN":["0006-4971","1528-0020"],"issn-type":[{"value":"0006-4971","type":"print"},{"value":"1528-0020","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,9]]}}}